HitPredict

Interactor 1: LA (P05455)
Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B)
Gene: SSB

Interactor 2: NUCL (P19338)
Nucleolin (Protein C23)
Gene: NCL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	12096904, 18292223
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	La~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:1990904 - ribonucleoprotein complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 408 Hs			1 710
+	Hs
		403212 LA_HUMAN (1-408): 4.97e-104: 315: 100.00		PABP4_HUMAN (222-488): 1.86e-42: 165: 14.88
+	Hs
		582322 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		NUCL_HUMAN (1-650): 8.84e-98: 318: 100.00
+	At
		285476 LRP6B_ARATH (12-258): 6.05e-55: 191: 19.48		PABP2_ARATH (204-491): 2.46e-40: 159: 15.21
+	At
		285478 LRP6B_ARATH (12-258): 6.05e-55: 191: 19.48		PABP8_ARATH (206-491): 3.9e-39: 155: 16.29
+	Hs
		474034 PAB4L_HUMAN (69-333): 1.17e-44: 160: 15.30		PABP5_HUMAN (233-555): 7.34e-51: 183: 17.20
+	Sc
		376709 LHP1_YEAST (8-207): 1.39e-36: 136: 21.76		PABP_YEAST (181-555): 3.61e-53: 194: 17.47
+	Hs
		474021 PAB4L_HUMAN (69-333): 1.17e-44: 160: 15.30		PABP4_HUMAN (222-488): 1.86e-42: 165: 14.88
+	Mm
		665745 TIA1_MOUSE (106-327): 7.74e-43: 156: 14.16		PABP1_MOUSE (222-482): 5.43e-43: 167: 15.55
+	Sc
		376562 PABP_YEAST (101-315): 1.22e-30: 125: 15.53		PABP_YEAST (181-555): 3.61e-53: 194: 17.47
+	Zm
		8143 A0A1D6ELH4_MAIZE (32-322): 1.15e-44: 165: 13.81		A0A1D6ELH4_MAIZE (204-491): 4.85e-38: 152: 15.53
+	Hs
		516541 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55
+	At
		790116 LRP6C_ARATH (11-202): 1.42e-42: 156: 20.59		PABP2_ARATH (204-491): 2.46e-40: 159: 15.21
+	Hs
		1116542 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		PABP3_HUMAN (221-482): 6.38e-43: 166: 16.20
+	Hs
		1031352 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		PABP4_HUMAN (222-488): 1.86e-42: 165: 14.88
+	Hs
		516689 PABP3_HUMAN (102-408): 3.51e-32: 130: 14.02		PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55
+	Hs
		516635 PABP5_HUMAN (98-321): 2.76e-25: 108: 15.42		PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55
+	Hs
		1116304 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		PAP1L_HUMAN (569-655): 2.88e-17: 87.7: 25.56
+	Sc
		693977 LHP1_YEAST (8-207): 1.39e-36: 136: 21.76		PUB1_YEAST (475-648): 4.1e-16: 83.6: 28.89
+	Sc
		376694 PABP_YEAST (101-315): 1.22e-30: 125: 15.53		PUB1_YEAST (475-648): 4.1e-16: 83.6: 28.89