Protein: CO6A2
Collagen alpha-2(VI) chain

Gene: CO6A2, COL6A2
Organism: Homo sapiens
Interactions: 95
UniProt ID: P12110

Gene Ontology (top 5):
GO:0005589 - collagen type VI trimer
GO:0005518 - collagen binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005788 - endoplasmic reticulum lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

505794

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

3

20

High-throughput

0.861

High

551891

C1QT2
Complement C1q tumor necrosis factor-related protein 2

3

20

High-throughput

0.861

High

551833

PRG2
Bone marrow proteoglycan

2

5

High-throughput

0.789

High

551836

CO9A1

2

16

High-throughput

0.789

High

551890

C1QT1
Complement C1q tumor necrosis factor-related protein 1

2

20

High-throughput

0.776

High

551903

PRG3
Proteoglycan 3

2

7

High-throughput

0.776

High

73770

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

20

High-throughput

0.691

High

388687

C1QB
Complement C1q subcomponent subunit B

1

20

High-throughput

0.691

High

388764

C1QC
Complement C1q subcomponent subunit C

1

20

High-throughput

0.691

High

469772

CATG
Cathepsin G

1

11

High-throughput

0.691

High

551838

CO8A2
Collagen alpha-2(VIII) chain

1

19

High-throughput

0.691

High

551889

COL11
Collectin-11

1

18

High-throughput

0.691

High

551893

SIRPD
Signal-regulatory protein delta

1

1

High-throughput

0.691

High

551902

COLQ
Acetylcholinesterase collagenic tail peptide

1

19

High-throughput

0.691

High

551858

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

2

High-throughput

0.667

High

469657

MMP2
72 kDa type IV collagenase

3

20

High-throughput

0.662

High

551878

LYPD1
Ly6/PLAUR domain-containing protein 1

3

1

High-throughput

0.662

High

143727

WN10B
Protein Wnt-10b

3

11

High-throughput

0.650

High

551850

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

7

Small-scale

0.647

High

551835

MMP9
Matrix metalloproteinase-9

2

20

High-throughput

0.628

High

551855

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

2

20

High-throughput

0.628

High

551868

LYZL1
Lysozyme-like protein 1

2

5

High-throughput

0.628

High

551871

LYZL2
Lysozyme-like protein 2

2

5

High-throughput

0.628

High

551872

TAFA3
Chemokine-like protein TAFA-3

2

2

High-throughput

0.628

High

551877

GT252
Procollagen galactosyltransferase 2

2

20

High-throughput

0.628

High

551887

TAFA4
Chemokine-like protein TAFA-4

2

2

High-throughput

0.628

High

551904

INSL5
Insulin-like peptide INSL5

2

2

High-throughput

0.628

High

168367

NCTR3
Natural cytotoxicity triggering receptor 3

1

1

High-throughput

0.618

High

551844

VEGFB
Vascular endothelial growth factor B

2

11

High-throughput

0.611

High

551899

OBP2A
Odorant-binding protein 2a

2

2

High-throughput

0.611

High

551863

DB121
Beta-defensin 121

2

0

High-throughput

0.602

High

551869

SG1D4
Secretoglobin family 1D member 4

2

0

High-throughput

0.602

High

251852

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

2

20

High-throughput

0.601

High

551834

EDN3
Endothelin-3

2

1

High-throughput

0.601

High

551866

LAIR2
Leukocyte-associated immunoglobulin-like receptor 2

2

13

High-throughput

0.601

High

551875

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

2

1

High-throughput

0.601

High

551883

PATE1
Prostate and testis expressed protein 1

2

1

High-throughput

0.601

High

551837

CO5A1

1

19

Small-scale

0.590

High

551901

DKKL1
Dickkopf-like protein 1

2

0

High-throughput

0.576

High

551876

SFPA2
Pulmonary surfactant-associated protein A2

1

19

High-throughput

0.575

High

551886

EMID1
EMI domain-containing protein 1

1

19

High-throughput

0.575

High

551859

TAZ
Tafazzin

2

1

High-throughput

0.558

High

551900

FBX2
F-box only protein 2

2

8

High-throughput

0.549

High

164758

GDF8
Growth/differentiation factor 8

1

8

High-throughput

0.536

High

192058

PA2GX
Group 10 secretory phospholipase A2

1

2

High-throughput

0.536

High

282819

CRLF1
Cytokine receptor-like factor 1

1

1

High-throughput

0.536

High

327028

NXPH3
Neurexophilin-3

1

1

High-throughput

0.536

High

416589

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

1

High-throughput

0.536

High

506818

CFC1
Cryptic protein

1

1

High-throughput

0.536

High

551842

XCL1
Lymphotactin

1

3

High-throughput

0.536

High

551849

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.536

High

551852

IL5RA
Interleukin-5 receptor subunit alpha

1

2

High-throughput

0.536

High

551860

DB136
Defensin beta 136

1

1

High-throughput

0.536

High

551861

DB135
Beta-defensin 135

1

1

High-throughput

0.536

High

551867

LYPD4
Ly6/PLAUR domain-containing protein 4

1

2

High-throughput

0.536

High

551879

TAFA2
Chemokine-like protein TAFA-2

1

2

High-throughput

0.536

High

551880

DB125
Beta-defensin 125

1

1

High-throughput

0.536

High

551882

GT251
Procollagen galactosyltransferase 1

1

20

High-throughput

0.536

High

551892

WN10A
Protein Wnt-10a

1

11

High-throughput

0.536

High

551894

IL25
Interleukin-25

1

1

High-throughput

0.536

High

551898

CBLN4
Cerebellin-4

1

20

High-throughput

0.536

High

335354

CCN6
Cellular communication network factor 6

1

0

High-throughput

0.513

High

551843

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.513

High

551851

NDP
Norrin

1

0

High-throughput

0.513

High

551881

DB123
Beta-defensin 123

1

0

High-throughput

0.513

High

551885

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

551895

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

551857

OZF
Zinc finger protein OZF

1

1

High-throughput

0.489

High

136804

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

5

High-throughput

0.479

High

137028

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

1

20

High-throughput

0.445

High

167434

WNT9A
Protein Wnt-9a

1

11

High-throughput

0.445

High

191286

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

7

High-throughput

0.445

High

248190

NDK8
Putative nucleoside diphosphate kinase

1

2

High-throughput

0.445

High

551839

KAIN
Kallistatin

1

4

High-throughput

0.445

High

551846

WNT3A
Protein Wnt-3a

1

11

High-throughput

0.445

High

551847

WNT4
Protein Wnt-4

1

11

High-throughput

0.445

High

551848

LCN6
Epididymal-specific lipocalin-6

1

2

High-throughput

0.445

High

551853

DEF5
Defensin alpha 5

1

3

High-throughput

0.445

High

105215

APRIO
Alternative prion protein

1

9

High-throughput

0.437

High

551845

EFNA3
Ephrin-A3

1

1

High-throughput

0.437

High

551856

MDC1
Mediator of DNA damage checkpoint protein 1

1

2

High-throughput

0.437

High

551870

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

222246

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.426

High

551840

RNAS4
Ribonuclease 4

1

0

High-throughput

0.426

High

551862

DB109
Beta-defensin 109B

1

0

High-throughput

0.426

High

551884

AP2C
Transcription factor AP-2 gamma

1

3

High-throughput

0.417

High

551896

DISC1
Disrupted in schizophrenia 1 protein

1

5

Small-scale

0.417

High

551841

I12R1
Interleukin-12 receptor subunit beta-1

1

2

High-throughput

0.407

High

551897

CAH10
Carbonic anhydrase-related protein 10

4

0

High-throughput

0.360

High

551854

CX6A2
Cytochrome c oxidase subunit 6A2, mitochondrial

1

0

High-throughput

0.282

High

551888

S38A3
Sodium-coupled neutral amino acid transporter 3

1

0

High-throughput

0.282

High

551865

DNLZ
DNL-type zinc finger protein

1

0

High-throughput

0.279

Low

551873

BTLA
B- and T-lymphocyte attenuator

1

0

High-throughput

0.279

Low

551874

IQCH
IQ domain-containing protein H

1

0

High-throughput

0.269

Low

551864

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025