Protein: MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1 (EC 2.3.2.27) (E3 SUMO-protein ligase MUL1) (E3 ubiquitin-protein ligase MUL1) (Growth inhibition and death E3 ligase) (Mitochondrial-anchored protein ligase) (Protein Hades) (Putative NF-kappa-B-activating protein 266) (RING finger protein 218) (RING-type E3 ubiquitin transferase NFKB 1)

Gene: MUL1
Organism: Homo sapiens
Interactions: 101
UniProt ID: Q969V5

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0000266 - mitochondrial fission
GO:0002039 - p53 binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

919811

UB2D2
Ubiquitin-conjugating enzyme E2 D2

6

20

Small-scale

0.950

High

849394

UB2D1
Ubiquitin-conjugating enzyme E2 D1

5

20

Small-scale

0.924

High

895867

UB2D3
Ubiquitin-conjugating enzyme E2 D3

4

20

Small-scale

0.896

High

1282320

UB2E3
Ubiquitin-conjugating enzyme E2 E3

3

20

Small-scale

0.852

High

851860

UB2E1
Ubiquitin-conjugating enzyme E2 E1

2

20

Small-scale

0.800

High

1282543

UB2D4
Ubiquitin-conjugating enzyme E2 D4

2

20

Small-scale

0.800

High

1282516

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

2

15

Small-scale

0.778

High

930339

UBC9
SUMO-conjugating enzyme UBC9

1

20

Small-scale

0.715

High

476157

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

13

Small-scale

0.710

High

387251

P53
Cellular tumor antigen p53

4

5

Small-scale

0.707

High

1268420

APBP2
Amyloid protein-binding protein 2

4

5

High-throughput

0.703

High

159080

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

20

High-throughput

0.698

High

1138898

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.698

High

1282519

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1160158

S39A4
Zinc transporter ZIP4

3

2

High-throughput

0.667

High

827997

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

20

Small-scale

0.647

High

896509

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.647

High

1079007

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

Small-scale

0.647

High

1174518

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

20

Small-scale

0.647

High

777241

PEX19
Peroxisomal biogenesis factor 19

3

0

High-throughput

0.638

High

1282534

ERAP1
Endoplasmic reticulum aminopeptidase 1

2

2

High-throughput

0.628

High

1282541

TRHDE
Thyrotropin-releasing hormone-degrading ectoenzyme

2

2

High-throughput

0.628

High

1282546

5MP1
eIF5-mimic protein 1

2

4

High-throughput

0.628

High

891422

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

20

Small-scale

0.621

High

932555

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

Small-scale

0.621

High

1282522

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

20

Small-scale

0.621

High

234351

GSDME
Gasdermin-E

2

0

High-throughput

0.602

High

1282533

SCN3B
Sodium channel regulatory subunit beta-3

2

0

High-throughput

0.602

High

262298

ULK1
Serine/threonine-protein kinase ULK1

1

9

Small-scale

0.578

High

681969

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

Small-scale

0.578

High

236444

RNBP6
Ran-binding protein 6

2

5

High-throughput

0.574

High

257205

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

2

1

High-throughput

0.574

High

1081483

CNGA3
Cyclic nucleotide-gated channel alpha-3

2

2

High-throughput

0.574

High

1119722

S39AC
Zinc transporter ZIP12

2

2

High-throughput

0.574

High

1170410

TBCD9
TBC1 domain family member 9

2

2

High-throughput

0.574

High

1282526

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

12

High-throughput

0.573

High

175905

P73
Tumor protein p73

1

5

Small-scale

0.561

High

1203559

STING
Stimulator of interferon genes protein

1

5

Small-scale

0.561

High

889616

KR108
Keratin-associated protein 10-8

2

1

High-throughput

0.553

High

928161

SUMO1
Small ubiquitin-related modifier 1

1

5

Small-scale

0.550

High

163917

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

5

High-throughput

0.536

High

321299

TBCD8
TBC1 domain family member 8

1

2

High-throughput

0.536

High

393306

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

4

High-throughput

0.536

High

729205

PDE6B
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

1

3

High-throughput

0.536

High

884052

GEMI4
Gem-associated protein 4

1

2

High-throughput

0.536

High

895698

CXCR4
C-X-C chemokine receptor type 4

1

2

High-throughput

0.536

High

957449

IDD
Integral membrane protein DGCR2/IDD

1

3

High-throughput

0.536

High

969057

GCYB1
Guanylate cyclase soluble subunit beta-1

1

1

High-throughput

0.536

High

1219353

CUL9
Cullin-9

1

2

High-throughput

0.536

High

1282532

STK36
Serine/threonine-protein kinase 36

1

7

High-throughput

0.536

High

1282542

SC5A6
Sodium-dependent multivitamin transporter

1

1

High-throughput

0.536

High

1282545

CBPQ
Carboxypeptidase Q

1

1

High-throughput

0.536

High

976750

TAP1
Antigen peptide transporter 1

1

0

High-throughput

0.518

High

1190046

MAVS
Mitochondrial antiviral-signaling protein

1

6

Small-scale

0.515

High

835095

TSC2
Tuberin

1

0

High-throughput

0.513

High

949234

COG7
Conserved oligomeric Golgi complex subunit 7

1

0

High-throughput

0.513

High

1218880

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1220568

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.513

High

1230989

DOCK4
Dedicator of cytokinesis protein 4

1

0

High-throughput

0.513

High

1282518

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

High-throughput

0.513

High

1282520

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.513

High

128610

DNM1L
Dynamin-1-like protein

1

2

Small-scale

0.501

High

201389

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

9

Small-scale

0.501

High

204010

HTRA2
Serine protease HTRA2, mitochondrial

1

15

Small-scale

0.501

High

299443

UBXN7
UBX domain-containing protein 7

1

6

Small-scale

0.501

High

801749

RAGP1
Ran GTPase-activating protein 1

1

9

Small-scale

0.501

High

1282529

EHD1
EH domain-containing protein 1

1

8

Small-scale

0.501

High

1031037

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

2

High-throughput

0.489

High

1282527

RBP17
Ran-binding protein 17

1

3

High-throughput

0.489

High

1282530

TTC12
Tetratricopeptide repeat protein 12

1

10

High-throughput

0.489

High

1282538

IPO11
Importin-11

1

8

High-throughput

0.489

High

306265

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

2

Small-scale

0.479

High

779865

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

875194

TERA
Transitional endoplasmic reticulum ATPase

1

2

Small-scale

0.479

High

1020852

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.479

High

1268853

AKAP1
A-kinase anchor protein 1, mitochondrial

1

2

High-throughput

0.479

High

1271732

TANK
TRAF family member-associated NF-kappa-B activator

1

3

Small-scale

0.479

High

1282523

VPS35
Vacuolar protein sorting-associated protein 35

1

1

Small-scale

0.479

High

1282536

ANFY1
Rabankyrin-5

1

1

Small-scale

0.479

High

1282540

HERC5
E3 ISG15--protein ligase HERC5

1

3

Small-scale

0.479

High

255182

ATG13
Autophagy-related protein 13

1

0

Small-scale

0.458

High

1282517

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

Small-scale

0.458

High

1282528

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

1282535

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

3

High-throughput

0.407

High

1282537

DYH17
Dynein axonemal heavy chain 17

1

5

High-throughput

0.407

High

1282524

HAUS7
HAUS augmin-like complex subunit 7

3

0

High-throughput

0.347

High

1157079

ARMC6
Armadillo repeat-containing protein 6

2

0

High-throughput

0.328

High

1263398

ATRIP
ATR-interacting protein

2

0

High-throughput

0.328

High

1236181

IQCF1
IQ domain-containing protein F1

2

0

High-throughput

0.318

High

1282525

REEP2
Receptor expression-enhancing protein 2

2

0

High-throughput

0.316

High

264731

VP26A
Vacuolar protein sorting-associated protein 26A

2

0

Small-scale

0.305

High

849060

GPC3
Glypican-3

1

0

High-throughput

0.279

Low

1089469

CC142
Coiled-coil domain-containing protein 142

1

0

High-throughput

0.279

Low

1093082

INSC
Protein inscuteable homolog

1

0

High-throughput

0.279

Low

1267982

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.279

Low

1282521

SAAL1
Protein SAAL1

1

0

High-throughput

0.279

Low

1282531

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.279

Low

1282539

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.279

Low

1282544

DOP2
Protein dopey-2

1

0

High-throughput

0.279

Low

1165825

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024