HitPredict

Interactor 1: SRC (P05480)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: WASP (P70315)
Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein homolog) (WASp)
Gene: Was

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	18289379
Identification Methods	anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005884 - actin filament GO:0005886 - plasma membrane GO:0019901 - protein kinase binding and 1 others more... GO:0043274 - phospholipase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Mm			1 520
+	Hs
		126905 SRC_HUMAN (1-535): 0: 645: 98.69		WASL_HUMAN (17-313): 4.22e-90: 286: 46.33
+	Hs
		522841 SRC_HUMAN (1-535): 0: 645: 98.69		WASP_HUMAN (12-505): 2.75e-70: 234: 86.24
+	Mm
		763384 FYN_MOUSE (1-535): 0: 594: 68.52		WASP_MOUSE (1-505): 3.19e-86: 277: 100.00
+	Hs
		126898 LCK_HUMAN (27-533): 0: 559: 54.01		WASL_HUMAN (17-313): 4.22e-90: 286: 46.33
+	Mm
		411923 LCK_MOUSE (27-533): 0: 557: 53.62		WASP_MOUSE (1-505): 3.19e-86: 277: 100.00
+	Mm
		435880 HCK_MOUSE (1-530): 0: 556: 55.18		WASP_MOUSE (1-505): 3.19e-86: 277: 100.00
+	Hs
		412072 FYN_HUMAN (1-535): 0: 595: 68.70		WASP_HUMAN (12-505): 2.75e-70: 234: 86.24
+	Hs
		454805 FGR_HUMAN (1-534): 0: 584: 65.36		WASP_HUMAN (12-505): 2.75e-70: 234: 86.24
+	Hs
		442791 HCK_HUMAN (1-530): 0: 566: 55.66		WASP_HUMAN (12-505): 2.75e-70: 234: 86.24
+	Hs
		411631 LCK_HUMAN (27-533): 0: 559: 54.01		WASP_HUMAN (12-505): 2.75e-70: 234: 86.24
+	Hs
		523092 SRC_HUMAN (1-535): 0: 645: 98.69		CBP_HUMAN (109-519): 3.58e-22: 103: 14.88
+	Hs
		522862 SRC_HUMAN (1-535): 0: 645: 98.69		DYN2_HUMAN (245-440): 8.05e-16: 82.8: 18.81
+	Hs
		522749 SRC_HUMAN (1-535): 0: 645: 98.69		MUC1_HUMAN (187-505): 7.14e-10: 63.9: 13.42
+	Hs
		412411 FYN_HUMAN (1-535): 0: 595: 68.70		DYN3_HUMAN (246-398): 5.78e-25: 111: 20.76
+	Hs
		412090 FYN_HUMAN (1-535): 0: 595: 68.70		DYN2_HUMAN (245-440): 8.05e-16: 82.8: 18.81
+	Hs
		442866 HCK_HUMAN (1-530): 0: 566: 55.66		CBP_HUMAN (109-519): 3.58e-22: 103: 14.88
+	Hs
		442794 HCK_HUMAN (1-530): 0: 566: 55.66		DYN2_HUMAN (245-440): 8.05e-16: 82.8: 18.81
+	Hs
		411645 LCK_HUMAN (27-533): 0: 559: 54.01		DYN2_HUMAN (245-440): 8.05e-16: 82.8: 18.81
+	Hs
		203198 LCK_HUMAN (27-533): 0: 559: 54.01		SYNJ1_HUMAN (220-507): 3.05e-11: 68.5: 13.18
+	Hs
		411582 LCK_HUMAN (27-533): 0: 559: 54.01		MUC1_HUMAN (187-505): 7.14e-10: 63.9: 13.42