HitPredict

Interactor 1: ITB1 (P05556)
Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29)
Gene: ITGB1

Interactor 2: ADA17 (P78536)
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b)
Gene: ADAM17

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 30455686, 22413019
Identification Methods anti bait coimmunoprecipitation, enzyme linked immunosorbent assay
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Disintegrin~EGF_2
Common GO terms GO:0005178 - integrin binding
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0007155 - cell adhesion
GO:0009986 - cell surface
and 6 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 798
Hs

1 824
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024