Protein: PRGR
Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3)

Gene: PRGR, PGR
Organism: Homo sapiens
Interactions: 147
UniProt ID: P06401

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001223 - transcription coactivator binding
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

442942

NCOA1
Nuclear receptor coactivator 1

5

20

Small-scale

0.907

High

395325

ESR1
Estrogen receptor

3

19

Small-scale

0.882

High

442934

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

4

20

Small-scale

0.867

High

442845

PRGR
Progesterone receptor

3

19

Small-scale

0.834

High

442969

NCOA3
Nuclear receptor coactivator 3

3

20

Small-scale

0.834

High

442850

HS90A
Heat shock protein HSP 90-alpha

3

20

Small-scale

0.817

High

442852

HS90B
Heat shock protein HSP 90-beta

2

20

Small-scale

0.755

High

442941

NCOA2
Nuclear receptor coactivator 2

2

20

Small-scale

0.754

High

442901

NR0B1
Nuclear receptor subfamily 0 group B member 1

1

20

Small-scale

0.724

High

442968

NCOR2
Nuclear receptor corepressor 2

3

20

Small-scale

0.653

High

442861

SRC
Proto-oncogene tyrosine-protein kinase Src

3

20

Small-scale

0.645

High

442887

BRCA1
Breast cancer type 1 susceptibility protein

2

16

Small-scale

0.629

High

442862

XRCC6
X-ray repair cross-complementing protein 6

2

12

Small-scale

0.629

High

442863

XRCC5
X-ray repair cross-complementing protein 5

2

12

Small-scale

0.629

High

442952

JDP2
Jun dimerization protein 2

2

19

Small-scale

0.624

High

442851

SP1
Transcription factor Sp1

2

20

Small-scale

0.621

High

442874

CDK2
Cyclin-dependent kinase 2

2

8

Small-scale

0.620

High

442927

UBE3A
Ubiquitin-protein ligase E3A

2

20

Small-scale

0.620

High

442923

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

20

Small-scale

0.618

High

442891

STAT3
Signal transducer and activator of transcription 3

2

17

Small-scale

0.612

High

442958

CUED2
CUE domain-containing protein 2

1

1

Small-scale

0.598

High

442953

KAT2B
Histone acetyltransferase KAT2B

2

20

Small-scale

0.595

High

442957

DNJC7
DnaJ homolog subfamily C member 7

2

20

Small-scale

0.595

High

297403

PIAS1
E3 SUMO-protein ligase PIAS1

2

20

Small-scale

0.584

High

442896

MAGAB
Melanoma-associated antigen 11

2

10

Small-scale

0.584

High

442867

PLAK
Junction plakoglobin

1

20

Small-scale

0.575

High

442947

H90B2
Putative heat shock protein HSP 90-beta 2

1

20

Small-scale

0.575

High

442936

KLF9
Krueppel-like factor 9

1

20

Small-scale

0.573

High

442856

PARP1
Poly [ADP-ribose] polymerase 1

2

19

Small-scale

0.571

High

442920

PRKDC
DNA-dependent protein kinase catalytic subunit

1

14

Small-scale

0.561

High

442885

BMI1
Polycomb complex protein BMI-1

1

15

Small-scale

0.552

High

442967

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

2

High-throughput

0.536

High

442919

CCNA1
Cyclin-A1

1

0

Small-scale

0.529

High

442956

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

19

Small-scale

0.527

High

442954

CSN5
COP9 signalosome complex subunit 5

1

12

Small-scale

0.527

High

442959

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

1

20

Small-scale

0.527

High

154608

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

Small-scale

0.501

High

297735

PIAS2
E3 SUMO-protein ligase PIAS2

1

20

Small-scale

0.501

High

297908

SPF27
Pre-mRNA-splicing factor SPF27

1

2

Small-scale

0.501

High

325649

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

Small-scale

0.501

High

442853

PO2F2
POU domain, class 2, transcription factor 2

1

20

Small-scale

0.501

High

442854

HMGB1
High mobility group protein B1

1

20

Small-scale

0.501

High

442866

PO2F1
POU domain, class 2, transcription factor 1

1

20

Small-scale

0.501

High

442870

TBP
TATA-box-binding protein

1

7

Small-scale

0.501

High

442875

HMGB2
High mobility group protein B2

1

20

Small-scale

0.501

High

442881

MPIP2
M-phase inducer phosphatase 2

1

2

Small-scale

0.501

High

442882

DNJA1
DnaJ homolog subfamily A member 1

1

16

Small-scale

0.501

High

442890

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

13

Small-scale

0.501

High

442899

RT29
Small ribosomal subunit protein mS29

1

4

Small-scale

0.501

High

442925

TF65
Transcription factor p65

1

20

Small-scale

0.501

High

442935

TDG
G/T mismatch-specific thymine DNA glycosylase

1

5

Small-scale

0.501

High

442937

RBM39
RNA-binding protein 39

1

20

Small-scale

0.501

High

442946

TAF1B
TATA box-binding protein-associated factor RNA polymerase I subunit B

1

3

Small-scale

0.501

High

442950

RBM23
Probable RNA-binding protein 23

1

20

Small-scale

0.501

High

442951

DDX54
ATP-dependent RNA helicase DDX54

1

20

Small-scale

0.501

High

442955

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

18

Small-scale

0.501

High

226669

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

20

Small-scale

0.481

High

442918

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

Small-scale

0.481

High

227310

SPOP
Speckle-type POZ protein

1

10

Small-scale

0.479

High

278206

NCOR1
Nuclear receptor corepressor 1

1

20

Small-scale

0.479

High

442871

FGFR2
Fibroblast growth factor receptor 2

1

6

Small-scale

0.479

High

442873

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

11

Small-scale

0.479

High

442878

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

20

Small-scale

0.479

High

442879

MK01
Mitogen-activated protein kinase 1

1

13

Small-scale

0.479

High

442884

HSP74
Heat shock 70 kDa protein 4

1

20

Small-scale

0.479

High

442894

STA5A
Signal transducer and activator of transcription 5A

1

17

Small-scale

0.479

High

442900

STA5B
Signal transducer and activator of transcription 5B

1

17

Small-scale

0.479

High

442904

PPP5
Serine/threonine-protein phosphatase 5

1

20

Small-scale

0.479

High

442906

ANM2
Protein arginine N-methyltransferase 2

1

13

Small-scale

0.479

High

442913

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

10

Small-scale

0.479

High

442930

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

442931

BPTF
Nucleosome-remodeling factor subunit BPTF

1

20

Small-scale

0.479

High

442932

PRDM2
PR domain zinc finger protein 2

1

14

Small-scale

0.479

High

442933

ZBT17
Zinc finger and BTB domain-containing protein 17

1

17

Small-scale

0.479

High

442943

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

Small-scale

0.479

High

442948

HERC4
Probable E3 ubiquitin-protein ligase HERC4

1

16

Small-scale

0.479

High

442962

CHIP
E3 ubiquitin-protein ligase CHIP

1

19

Small-scale

0.479

High

442966

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

12

Small-scale

0.479

High

442970

PIAS3
E3 SUMO-protein ligase PIAS3

1

20

Small-scale

0.479

High

141281

DDX3X
ATP-dependent RNA helicase DDX3X

1

15

Small-scale

0.445

High

250414

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

15

Small-scale

0.445

High

271212

CPNE3
Copine-3

1

3

Small-scale

0.445

High

385365

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

20

Small-scale

0.445

High

402489

ALDOA
Fructose-bisphosphate aldolase A

1

1

Small-scale

0.445

High

408614

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

5

Small-scale

0.445

High

410522

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

12

Small-scale

0.445

High

424726

ADT2
ADP/ATP translocase 2

1

14

Small-scale

0.445

High

428567

RLA0
Large ribosomal subunit protein uL10

1

6

Small-scale

0.445

High

442846

ENOA
Alpha-enolase

1

2

Small-scale

0.445

High

442847

NPM
Nucleophosmin

1

4

Small-scale

0.445

High

442848

ANXA2
Annexin A2

1

7

Small-scale

0.445

High

442849

TBB5
Tubulin beta chain

1

15

Small-scale

0.445

High

442855

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

20

Small-scale

0.445

High

442857

CH60
60 kDa heat shock protein, mitochondrial

1

7

Small-scale

0.445

High

442858

BIP
Endoplasmic reticulum chaperone BiP

1

20

Small-scale

0.445

High

442859

HSP7C
Heat shock cognate 71 kDa protein

1

17

Small-scale

0.445

High

442860

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

7

Small-scale

0.445

High

442864

EF2
Elongation factor 2

1

5

Small-scale

0.445

High

442865

KPYM
Pyruvate kinase PKM

1

2

Small-scale

0.445

High

442868

DESP
Desmoplakin

1

20

Small-scale

0.445

High

442869

DDX5
Probable ATP-dependent RNA helicase DDX5

1

17

Small-scale

0.445

High

442872

SFPQ
Splicing factor, proline- and glutamine-rich

1

20

Small-scale

0.445

High

442876

EF1G
Elongation factor 1-gamma

1

5

Small-scale

0.445

High

442877

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

Small-scale

0.445

High

442883

STIP1
Stress-induced-phosphoprotein 1

1

17

Small-scale

0.445

High

442886

RL4
Large ribosomal subunit protein uL4

1

2

Small-scale

0.445

High

442889

RL3
Large ribosomal subunit protein uL3

1

3

Small-scale

0.445

High

442892

LAP2A
Lamina-associated polypeptide 2, isoform alpha

1

3

Small-scale

0.445

High

442893

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

3

Small-scale

0.445

High

442895

MATR3
Matrin-3

1

13

Small-scale

0.445

High

442897

FAS
Fatty acid synthase

1

5

Small-scale

0.445

High

442898

DNLI3
DNA ligase 3

1

5

Small-scale

0.445

High

442902

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

20

Small-scale

0.445

High

442903

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

20

Small-scale

0.445

High

442905

ACLY
ATP-citrate synthase

1

2

Small-scale

0.445

High

442907

IF4A1
Eukaryotic initiation factor 4A-I

1

15

Small-scale

0.445

High

442908

RS3A
Small ribosomal subunit protein eS1

1

1

Small-scale

0.445

High

442909

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

16

Small-scale

0.445

High

442910

RS8
Small ribosomal subunit protein eS8

1

2

Small-scale

0.445

High

442911

RAN
GTP-binding nuclear protein Ran

1

18

Small-scale

0.445

High

442912

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

10

Small-scale

0.445

High

442914

ACTG
Actin, cytoplasmic 2

1

15

Small-scale

0.445

High

442915

YBOX1
Y-box-binding protein 1

1

4

Small-scale

0.445

High

442917

TBB4B
Tubulin beta-4B chain

1

15

Small-scale

0.445

High

442921

S25A3
Solute carrier family 25 member 3

1

20

Small-scale

0.445

High

442922

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

20

Small-scale

0.445

High

442924

RL6
Large ribosomal subunit protein eL6

1

1

Small-scale

0.445

High

442926

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

14

Small-scale

0.445

High

442928

PRDX1
Peroxiredoxin-1

1

14

Small-scale

0.445

High

442929

RBBP4
Histone-binding protein RBBP4

1

20

Small-scale

0.445

High

442938

TEBP
Prostaglandin E synthase 3

1

7

Small-scale

0.445

High

442939

NONO
Non-POU domain-containing octamer-binding protein

1

20

Small-scale

0.445

High

442940

DHC24
Delta(24)-sterol reductase

1

1

Small-scale

0.445

High

442944

SEPT7
Septin-7

1

11

Small-scale

0.445

High

442949

EF1A3
Putative elongation factor 1-alpha-like 3

1

9

Small-scale

0.445

High

442961

PUF60
Poly(U)-binding-splicing factor PUF60

1

20

Small-scale

0.445

High

442963

PA2G4
Proliferation-associated protein 2G4

1

5

Small-scale

0.445

High

442964

RUVB2
RuvB-like 2

1

7

Small-scale

0.445

High

442965

RUVB1
RuvB-like 1

1

7

Small-scale

0.445

High

403110

APOB
Apolipoprotein B-100

1

0

Small-scale

0.426

High

442880

GRN
Progranulin

1

0

Small-scale

0.426

High

423871

ALDH2
Aldehyde dehydrogenase, mitochondrial

1

1

Small-scale

0.407

High

442888

HSPA9
Stress-70 protein, mitochondrial

1

20

Small-scale

0.407

High

442916

TBA1B
Tubulin alpha-1B chain

1

19

Small-scale

0.407

High

442945

MIC60
MICOS complex subunit MIC60

1

2

Small-scale

0.407

High

442960

SEPT9
Septin-9

1

11

Small-scale

0.407

High


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Last updated: 11Aug2025