HitPredict

Interactor 1: JUN (P05627)
Transcription factor Jun (AH119) (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (Jun A)
Gene: JUN

Interactor 2: SIR1 (Q923E4)
NAD-dependent protein deacetylase sirtuin-1 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (SIR2alpha) (Sir2) (mSIR2a) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: Sirt1

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.612

The method score is based on:

Property	Details
Experiments	18676681, 20042607
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001525 - angiogenesis GO:0001938 - positive regulation of endothelial cell proliferation GO:0005634 - nucleus and 8 others more... GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0008284 - positive regulation of cell population proliferation GO:0032991 - protein-containing complex GO:0043065 - positive regulation of apoptotic process GO:0043066 - negative regulation of apoptotic process GO:0043524 - negative regulation of neuron apoptotic process GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	334
Mm

1	737

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024