HitPredict

Interactor 1: KPCB (P05771)
Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)
Gene: PRKCB

Interactor 2: NCF1 (P14598)
Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)
Gene: NCF1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	11120743, 12056906, 17069809
Identification Methods	affinity chromatography technology, enzymatic study, protein kinase assay
Interaction Type	physical association, direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 671 Hs			1 390
+	Hs
		537591 KPCA_HUMAN (1-668): 0: 742: 78.89		NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00
+	Hs
		408668 KPCB_HUMAN (1-671): 0: 774: 100.00		SH3G3_HUMAN (222-285): 2.65e-18: 87.1: 12.50
+	Hs
		537603 AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33		NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00
+	Hs
		298951 AKT2_HUMAN (237-665): 2.34e-159: 469: 37.87		SRBS2_HUMAN (163-283): 1.9e-20: 95.7: 21.15
+	Hs
		235479 AKT2_HUMAN (237-665): 2.34e-159: 469: 37.87		VINEX_HUMAN (85-388): 1.86e-14: 77: 12.95
+	Hs
		681922 AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33		SH3R1_HUMAN (62-281): 1.75e-09: 61.7: 14.87
+	Hs
		682191 AKT2_HUMAN (237-665): 2.34e-159: 469: 37.87		SH3R1_HUMAN (62-281): 1.75e-09: 61.7: 14.87
+	Hs
		537632 KPCD_HUMAN (6-167): 1.49e-54: 199: 40.83		NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00
+	Hs
		537631 KPCZ_HUMAN (10-86): 4.47e-12: 71.2: 36.36		NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00
+	Dm
		54628 APKC_DROME (4-86): 7.85e-14: 76.6: 39.76		M9ND00_DROME (93-384): 4.02e-26: 112: 15.15
+	Hs
		983935 KPCZ_HUMAN (10-86): 4.47e-12: 71.2: 36.36		ITSN2_HUMAN (8-390): 2.54e-15: 80.2: 11.00