Protein: EI2BB
Translation initiation factor eIF2B subunit beta (GCD complex subunit GCD7) (Guanine nucleotide exchange factor subunit GCD7) (eIF2B GDP-GTP exchange factor subunit beta)

Gene: EI2BB, GCD7
Organism: Saccharomyces cerevisiae S288C
Interactions: 189
UniProt ID: P32502

Gene Ontology (top 5):
GO:0002183 - cytoplasmic translational initiation
GO:0003743 - translation initiation factor activity
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0005851 - eukaryotic translation initiation factor 2B complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

738573

EI2BE
Translation initiation factor eIF2B subunit epsilon

14

15

Small-scale

0.983

High

575318

EI2BA
Translation initiation factor eIF2B subunit alpha

12

13

Small-scale

0.981

High

555298

EI2BD
Translation initiation factor eIF2B subunit delta

11

15

Small-scale

0.979

High

632871

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

5

4

Small-scale

0.919

High

478403

EI2BG
Translation initiation factor eIF2B subunit gamma

15

15

Small-scale

0.764

High

737692

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

8

7

Small-scale

0.749

High

478601

IF2B
Eukaryotic translation initiation factor 2 subunit beta

5

7

Small-scale

0.714

High

738687

MUK1
Protein MUK1

5

0

Small-scale

0.682

High

738617

EI2BB
Translation initiation factor eIF2B subunit beta

1

14

High-throughput

0.656

High

738647

MET10
Sulfite reductase [NADPH] flavoprotein component

2

1

High-throughput

0.618

High

733576

P5CR
Pyrroline-5-carboxylate reductase

2

0

High-throughput

0.598

High

738705

CDD
Cytidine deaminase

2

0

High-throughput

0.594

High

579052

HSC82
ATP-dependent molecular chaperone HSC82

2

7

High-throughput

0.584

High

738636

PHS
Putative pterin-4-alpha-carbinolamine dehydratase

2

0

High-throughput

0.565

High

738621

SUI1
Eukaryotic translation initiation factor eIF-1

1

1

Small-scale

0.561

High

738631

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

2

2

Small-scale

0.560

High

738641

KOG1
Target of rapamycin complex 1 subunit KOG1

1

6

High-throughput

0.552

High

738695

RUVB1
RuvB-like protein 1

2

2

High-throughput

0.543

High

738682

IST1
Vacuolar protein sorting-associated protein IST1

2

2

High-throughput

0.537

High

644890

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

2

High-throughput

0.536

High

738624

XPOT
Exportin-T

1

10

High-throughput

0.536

High

738652

VAC8
Vacuolar protein 8

1

1

High-throughput

0.536

High

738656

FKH1
Fork head protein homolog 1

1

3

High-throughput

0.536

High

738691

GCN5
Histone acetyltransferase GCN5

1

3

High-throughput

0.536

High

386633

TBB
Tubulin beta chain

2

2

High-throughput

0.533

High

486094

TBA1
Tubulin alpha-1 chain

2

3

High-throughput

0.533

High

486432

TBA3
Tubulin alpha-3 chain

2

3

High-throughput

0.533

High

738663

MPG1
Mannose-1-phosphate guanyltransferase

1

11

High-throughput

0.514

High

738657

MET18
DNA repair/transcription protein MET18/MMS19

1

0

High-throughput

0.513

High

738660

SYA
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

738667

NMD5
Nonsense-mediated mRNA decay protein 5

1

0

High-throughput

0.513

High

368148

THDH
Threonine dehydratase, mitochondrial

1

2

High-throughput

0.508

High

438840

CATT
Catalase T

1

1

High-throughput

0.508

High

556997

AAKG
5'-AMP-activated protein kinase subunit gamma

1

1

High-throughput

0.508

High

581925

CATA
Peroxisomal catalase A

1

1

High-throughput

0.508

High

616400

SEC18
Vesicular-fusion protein SEC18

1

4

High-throughput

0.508

High

738649

RSP5
E3 ubiquitin-protein ligase RSP5

1

1

High-throughput

0.508

High

738668

MDV1
Mitochondrial division protein 1

1

2

High-throughput

0.508

High

738632

IF5
Eukaryotic translation initiation factor 5

1

16

Small-scale

0.501

High

392426

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.500

High

405060

LEU3
3-isopropylmalate dehydrogenase

1

2

High-throughput

0.500

High

408303

GAL1
Galactokinase

1

1

High-throughput

0.500

High

408561

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

2

High-throughput

0.500

High

416403

HXKA
Hexokinase-1

1

1

High-throughput

0.500

High

416530

HXKB
Hexokinase-2

1

1

High-throughput

0.500

High

420898

PMA1
Plasma membrane ATPase 1

1

2

High-throughput

0.500

High

456364

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

3

High-throughput

0.500

High

481537

HSP73
Heat shock protein SSA3

1

4

High-throughput

0.500

High

544187

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.500

High

626655

HSP60
Heat shock protein 60, mitochondrial

1

2

High-throughput

0.500

High

675821

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.500

High

679489

CDC48
Cell division control protein 48

1

2

High-throughput

0.500

High

738651

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.500

High

399355

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

3

High-throughput

0.489

High

721778

XPO1
Exportin-1

1

10

High-throughput

0.489

High

738619

VATD
V-type proton ATPase subunit D

1

1

High-throughput

0.489

High

738670

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

1

High-throughput

0.489

High

738678

SCW4
Probable family 17 glucosidase SCW4

1

1

High-throughput

0.489

High

470714

MET3
Sulfate adenylyltransferase

1

0

High-throughput

0.486

High

479672

F16P
Fructose-1,6-bisphosphatase

1

0

High-throughput

0.486

High

673042

PET18
Protein PET18

1

0

High-throughput

0.486

High

673087

RNQ1
[PIN+] prion protein RNQ1

1

0

High-throughput

0.486

High

692490

GYS2
Glycogen [starch] synthase isoform 2

1

0

High-throughput

0.486

High

701587

UBC8
Ubiquitin-conjugating enzyme E2-24 kDa

1

0

High-throughput

0.486

High

733791

THI4
Thiamine thiazole synthase

1

0

High-throughput

0.486

High

738620

CACP
Carnitine O-acetyltransferase, mitochondrial

1

0

High-throughput

0.486

High

738626

UBX1
UBX domain-containing protein 1

1

0

High-throughput

0.486

High

738633

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.486

High

738639

UBA4
Adenylyltransferase and sulfurtransferase UBA4

1

0

High-throughput

0.486

High

738661

YJV8
Putative acetyltransferase YJL218W

1

0

High-throughput

0.486

High

738662

MVP1
Sorting nexin MVP1

1

0

High-throughput

0.486

High

738664

WWM1
WW domain-containing protein WWM1

1

0

High-throughput

0.486

High

738677

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.486

High

738683

DNM1
Dynamin-related protein DNM1

1

0

High-throughput

0.486

High

738688

AAD16
Putative aryl-alcohol dehydrogenase AAD16

1

0

High-throughput

0.486

High

738690

SNO1
Pyridoxal 5'-phosphate synthase subunit SNO1

1

0

High-throughput

0.486

High

738702

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.486

High

738709

LOT6
NAD(P)H-dependent FMN reductase LOT6

1

0

High-throughput

0.486

High

738715

GGPPS
Geranylgeranyl pyrophosphate synthase BTS1

1

0

High-throughput

0.486

High

738719

ATG34
Autophagy-related protein 34

1

0

High-throughput

0.486

High

738721

PST2
Protoplast secreted protein 2

1

0

High-throughput

0.486

High

452488

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.479

High

598829

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

0

High-throughput

0.479

High

738665

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.479

High

434931

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

436355

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

6

High-throughput

0.479

High

441784

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

454941

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

726849

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

738628

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

738645

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.479

High

738648

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

738654

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.479

High

738671

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.479

High

738686

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

738696

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

738712

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.479

High

561186

PYRE
Orotate phosphoribosyltransferase 1

1

1

High-throughput

0.464

High

576951

AMPL
Vacuolar aminopeptidase 1

1

1

High-throughput

0.464

High

712956

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.464

High

738640

DNPEP
Aspartyl aminopeptidase 4

1

1

High-throughput

0.464

High

738669

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

4

High-throughput

0.464

High

738684

LSM3
LSM complex subunit LSM3

1

3

High-throughput

0.464

High

738685

ACT
Actin

1

2

High-throughput

0.464

High

383586

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

504105

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.458

High

558642

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

575414

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

1

High-throughput

0.457

High

701672

URA7
CTP synthase 1

1

1

High-throughput

0.457

High

738627

BMH2
Protein BMH2

1

4

High-throughput

0.457

High

738634

YHI0
Putative proline--tRNA ligase YHR020W

1

1

High-throughput

0.457

High

738720

HSP42
Heat shock protein 42

1

5

High-throughput

0.457

High

453484

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.445

High

510311

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.445

High

738638

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.445

High

682210

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.437

High

706522

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

738707

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

364984

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.407

High

376181

RAS1
Ras-like protein 1

1

1

High-throughput

0.407

High

471388

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

1

High-throughput

0.407

High

592104

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.407

High

597411

EF3A
Elongation factor 3A

1

1

High-throughput

0.407

High

738622

PRS7
26S proteasome regulatory subunit 7 homolog

1

4

High-throughput

0.407

High

738644

TCPG
T-complex protein 1 subunit gamma

1

5

High-throughput

0.407

High

738655

PRS4
26S proteasome regulatory subunit 4 homolog

1

1

High-throughput

0.407

High

738679

PRS10
26S proteasome subunit RPT4

1

4

High-throughput

0.407

High

738716

HUA2
Protein HUA2

2

0

High-throughput

0.323

High

738618

RTG2
Retrograde regulation protein 2

2

0

High-throughput

0.310

High

678857

CSM1
Monopolin complex subunit CSM1

2

0

High-throughput

0.307

High

738704

ATG17
Autophagy-related protein 17

2

0

High-throughput

0.307

High

738706

VAC14
Vacuole morphology and inheritance protein 14

2

0

High-throughput

0.307

High

738713

RDR1
Protein RDR1

2

0

High-throughput

0.307

High

738646

MBB1
Uncharacterized protein MBB1

2

0

High-throughput

0.295

High

548264

FUS1
Nuclear fusion protein FUS1

1

0

High-throughput

0.282

High

738625

SPC29
Spindle pole component 29

1

0

High-throughput

0.282

High

738676

THG1
tRNA(His) guanylyltransferase

1

0

High-throughput

0.282

High

738714

TGL5
Triacylglycerol lipase 5

1

0

High-throughput

0.282

High

676618

SGF29
SAGA complex subunit SGF29

1

0

High-throughput

0.279

Low

738643

FET3
Iron transport multicopper oxidase FET3

1

0

High-throughput

0.279

Low

693506

PUR7
Phosphoribosylaminoimidazole-succinocarboxamide synthase

1

0

High-throughput

0.269

Low

365785

KTHY
Thymidylate kinase

1

0

High-throughput

0.265

Low

423584

ARGR2
Arginine metabolism regulation protein II

1

0

High-throughput

0.265

Low

627754

TYR1
Prephenate dehydrogenase [NADP(+)]

1

0

High-throughput

0.265

Low

639892

DAL82
Protein DAL82

1

0

High-throughput

0.265

Low

642353

MCK1
Protein kinase MCK1

1

0

High-throughput

0.265

Low

654772

URE2
Transcriptional regulator URE2

1

0

High-throughput

0.265

Low

684904

DAL80
Nitrogen regulatory protein DAL80

1

0

High-throughput

0.265

Low

693217

URK1
Uridine kinase

1

0

High-throughput

0.265

Low

738623

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.265

Low

738629

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

0

High-throughput

0.265

Low

738630

PBP2
PAB1-binding protein 2

1

0

High-throughput

0.265

Low

738635

YHR2
Uncharacterized trans-sulfuration enzyme YHR112C

1

0

High-throughput

0.265

Low

738637

YAP3
AP-1-like transcription factor YAP3

1

0

High-throughput

0.265

Low

738650

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

0

High-throughput

0.265

Low

738658

SER33
D-3-phosphoglycerate dehydrogenase 2

1

0

High-throughput

0.265

Low

738659

YIV5
Uncharacterized oxidoreductase YIR035C

1

0

High-throughput

0.265

Low

738666

COM1
DNA endonuclease SAE2

1

0

High-throughput

0.265

Low

738672

RIB4
6,7-dimethyl-8-ribityllumazine synthase

1

0

High-throughput

0.265

Low

738673

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.265

Low

738675

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.265

Low

738680

PRA1
Prenylated Rab acceptor 1

1

0

High-throughput

0.265

Low

738681

SNZ2
Probable pyridoxal 5'-phosphate synthase subunit SNZ2

1

0

High-throughput

0.265

Low

738689

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.265

Low

738692

DIG2
Down-regulator of invasive growth 2

1

0

High-throughput

0.265

Low

738697

KFA
Kynurenine formamidase

1

0

High-throughput

0.265

Low

738698

URC2
Uracil catabolism protein 2

1

0

High-throughput

0.265

Low

738701

CYK2
Cytokinesis protein 2

1

0

High-throughput

0.265

Low

738703

SFH1
Chromatin structure-remodeling complex subunit SFH1

1

0

High-throughput

0.265

Low

738708

YD144
Uncharacterized protein YDL144C

1

0

High-throughput

0.265

Low

738710

ALR1
Magnesium transporter ALR1

1

0

High-throughput

0.265

Low

738711

CUE5
Ubiquitin-binding protein CUE5

1

0

High-throughput

0.265

Low

738717

FCY1
Cytosine deaminase

1

0

High-throughput

0.265

Low

738718

RPIA
Ribose-5-phosphate isomerase

1

0

High-throughput

0.265

Low

738722

JLP1
Alpha-ketoglutarate-dependent sulfonate dioxygenase

1

0

High-throughput

0.265

Low

738724

YO21A
Transposon Ty2-OR1 Gag polyprotein

1

0

High-throughput

0.265

Low

738725

NTPPA
dTTP/UTP pyrophosphatase

1

0

High-throughput

0.265

Low

738726

DET1
Broad-range acid phosphatase DET1

1

0

High-throughput

0.265

Low

432304

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.261

Low

597079

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.261

Low

738693

ARX1
Probable metalloprotease ARX1

1

0

High-throughput

0.249

Low

738694

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.249

Low

738699

TAF7
Transcription initiation factor TFIID subunit 7

1

0

High-throughput

0.249

Low

738723

RIB2
Bifunctional protein RIB2 [Includes: tRNA pseudouridine(32) synthase, cytoplasmic

1

0

High-throughput

0.249

Low

738642

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.232

Low

738653

IMB4
Importin subunit beta-4

1

0

High-throughput

0.232

Low

738674

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.232

Low

738700

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025