HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: PTN6 (P29350)
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)
Gene: PTPN6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	7512963, 28065597
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0007186 - G protein-coupled receptor signaling pathway GO:0008284 - positive regulation of cell population proliferation GO:0016020 - membrane GO:0018108 - peptidyl-tyrosine phosphorylation GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 595
+	Hs
		435549 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		PTN6_HUMAN (1-595): 0: 628: 100.00
+	Hs
		411297 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTPRB_HUMAN (102-541): 2.73e-119: 391: 26.85
+	Hs
		411302 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTN3_HUMAN (118-523): 9.92e-122: 383: 27.70
+	Hs
		411393 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTPRR_HUMAN (5-515): 1.13e-123: 381: 24.86
+	Hs
		411291 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTN1_HUMAN (230-591): 2.86e-126: 380: 29.86
+	Hs
		411369 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTPRJ_HUMAN (234-549): 8.15e-115: 373: 33.12
+	Hs
		411278 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTPRC_HUMAN (118-575): 2.27e-82: 283: 20.20
+	Hs
		411394 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTPRK_HUMAN (72-519): 3.22e-71: 251: 21.06
+	Hs
		411298 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTPRG_HUMAN (130-547): 4.44e-60: 218: 20.14
+	Hs
		435648 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		PTPRR_HUMAN (5-515): 1.13e-123: 381: 24.86
+	Hs
		435529 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		PTN1_HUMAN (230-591): 2.86e-126: 380: 29.86
+	Hs
		411361 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTN12_HUMAN (253-530): 7.2e-50: 186: 39.43
+	Hs
		537715 INSRR_HUMAN (13-1341): 0: 1293: 51.12		PTN1_HUMAN (230-591): 2.86e-126: 380: 29.86
+	Rn
		783510 T2CB11_RAT (1-1382): 0: 1538: 94.87		PTN11_RAT (2-203): 1.58e-24: 109: 25.23
+	Hs
		411363 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTN11_HUMAN (2-203): 1.25e-24: 110: 25.23
+	Hs
		435618 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		PTN12_HUMAN (253-530): 7.2e-50: 186: 39.43
+	Hs
		435620 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		PTN11_HUMAN (2-203): 1.25e-24: 110: 25.23
+	Dm
		448231 INSR_DROME (30-1382): 0: 1002: 34.55		LAR_DROME (97-516): 3.62e-106: 353: 27.23
+	Dm
		448233 INSR_DROME (30-1382): 0: 1002: 34.55		PTP99_DROME (76-575): 1.84e-51: 193: 15.95
+	Hs
		872635 EPHA4_HUMAN (562-1354): 0: 565: 20.36		PTN11_HUMAN (2-203): 1.25e-24: 110: 25.23