HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: DNJA1 (P31689)
DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2)
Gene: DNAJA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 397
+	Hs
		243254 INSR_HUMAN (1-1382): 0: 1530: 100.00		DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55
+	Hs
		411469 INSR_HUMAN (1-1382): 0: 1530: 100.00		DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93
+	Hs
		435551 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		DNJA1_HUMAN (1-397): 3.98e-171: 485: 100.00
+	Hs
		243262 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55
+	Hs
		435729 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93
+	Hs
		411515 INSR_HUMAN (1-1382): 0: 1530: 100.00		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15
+	Hs
		435790 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15
+	Hs
		537779 INSRR_HUMAN (13-1341): 0: 1293: 51.12		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15
+	Dm
		448256 INSR_DROME (30-1382): 0: 1002: 34.55		Q9VFV9_DROME (1-397): 1.49e-137: 400: 58.77
+	Hs
		383639 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		DNJA1_HUMAN (1-397): 3.98e-171: 485: 100.00
+	Hs
		243250 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55
+	Hs
		665541 EPHA8_HUMAN (644-1322): 3.66e-168: 531: 20.68		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15
+	Hs
		445882 ROS1_HUMAN (511-1377): 3.38e-158: 530: 22.63		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15
+	Hs
		243669 ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53		DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55
+	Hs
		383929 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93
+	Hs
		666634 LTK_HUMAN (1013-1291): 2e-71: 259: 44.52		DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93
+	Mm
		1142038 MUSK_MOUSE (1017-1291): 3.2e-70: 256: 42.56		DNJA3_MOUSE (2-387): 1.71e-113: 341: 25.31
+	Hs
		384016 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15
+	Hs
		1354290 ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15
+	Hs
		666658 LTK_HUMAN (1013-1291): 2e-71: 259: 44.52		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15