Protein: PYRG2
CTP synthase 2 (EC 6.3.4.2) (CTP synthetase 2) (UTP--ammonia ligase 2)

Gene: PYRG2, CTPS2
Organism: Homo sapiens
Interactions: 89
UniProt ID: Q9NRF8

Gene Ontology (top 5):
GO:0003883 - CTP synthase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

608198

PYRG1
CTP synthase 1

7

9

High-throughput

0.961

High

1448426

PYRG2
CTP synthase 2

4

9

Small-scale

0.900

High

1448428

SPG21
Maspardin

2

0

High-throughput

0.618

High

1231212

TIGD3
Tigger transposable element-derived protein 3

2

1

High-throughput

0.574

High

1311562

SUGP1
SURP and G-patch domain-containing protein 1

2

1

High-throughput

0.574

High

541704

FGFR1
Fibroblast growth factor receptor 1

1

3

High-throughput

0.541

High

978750

RL23A
Large ribosomal subunit protein uL23

1

2

High-throughput

0.541

High

249669

SNX3
Sorting nexin-3

1

1

High-throughput

0.536

High

1034832

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

1

High-throughput

0.536

High

1316634

CDK20
Cyclin-dependent kinase 20

1

2

High-throughput

0.536

High

1334969

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.536

High

1391423

OTUD5
OTU domain-containing protein 5

1

1

High-throughput

0.536

High

961857

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.518

High

66946

AQ12B
Putative aquaporin-12B

1

0

High-throughput

0.513

High

287484

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.513

High

377005

ANF
Natriuretic peptides A

1

0

High-throughput

0.513

High

538699

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

0

High-throughput

0.513

High

881103

NASP
Nuclear autoantigenic sperm protein

1

0

High-throughput

0.513

High

902253

RAB28
Ras-related protein Rab-28

1

0

High-throughput

0.513

High

1151894

RHOH
Rho-related GTP-binding protein RhoH

1

0

High-throughput

0.513

High

1163944

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.513

High

1205772

EFMT2
EEF1A lysine methyltransferase 2

1

0

High-throughput

0.513

High

1380394

I22R2
Interleukin-22 receptor subunit alpha-2

1

0

High-throughput

0.513

High

1389214

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.513

High

1448427

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.513

High

1448434

TBX20
T-box transcription factor TBX20

1

0

High-throughput

0.513

High

1448437

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.513

High

869795

MTR1A
Melatonin receptor type 1A

1

1

High-throughput

0.494

High

941577

CTBP2
C-terminal-binding protein 2

1

2

High-throughput

0.494

High

182790

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

700806

DMB
HLA class II histocompatibility antigen, DM beta chain

1

1

High-throughput

0.489

High

1108812

ASAH1
Acid ceramidase

1

1

High-throughput

0.489

High

1420326

CD244
Natural killer cell receptor 2B4

1

1

High-throughput

0.489

High

1448436

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

1

High-throughput

0.489

High

1448438

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

173422

XPO1
Exportin-1

1

1

High-throughput

0.479

High

316050

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

412665

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

971143

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

1035939

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

1114401

CUL3
Cullin-3

1

5

High-throughput

0.479

High

1138672

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

1255696

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1397463

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1404785

RING2
E3 ubiquitin-protein ligase RING2

1

1

High-throughput

0.479

High

1433987

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1448430

XPO7
Exportin-7

1

1

High-throughput

0.479

High

710513

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.458

High

942913

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

1385395

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.458

High

1448435

FAF1
FAS-associated factor 1

1

0

High-throughput

0.458

High

564423

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

589793

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

696607

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

769274

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1100429

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.437

High

1101311

SLAF1
Signaling lymphocytic activation molecule

1

2

High-throughput

0.437

High

1276834

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1429359

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

653593

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1448432

MCTS1
Malignant T-cell-amplified sequence 1

1

0

High-throughput

0.426

High

49546

SHSA3
Protein shisa-3 homolog

1

0

High-throughput

0.279

Low

216548

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

0

High-throughput

0.279

Low

219832

CHSTA
Carbohydrate sulfotransferase 10

1

0

High-throughput

0.279

Low

231018

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.279

Low

260969

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

564935

ICAM2
Intercellular adhesion molecule 2

1

0

High-throughput

0.279

Low

733084

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

High-throughput

0.279

Low

771241

APJ
Apelin receptor

1

0

High-throughput

0.279

Low

1022097

TSG6
Tumor necrosis factor-inducible gene 6 protein

1

0

High-throughput

0.279

Low

1091909

NPRL3
GATOR1 complex protein NPRL3

1

0

High-throughput

0.279

Low

1159240

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.279

Low

1187694

T10IP
Testis-specific protein 10-interacting protein

1

0

High-throughput

0.279

Low

1211637

SPT46
Spermatogenesis-associated protein 46

1

0

High-throughput

0.279

Low

1336531

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.279

Low

1349124

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1351511

RNH2C
Ribonuclease H2 subunit C

1

0

High-throughput

0.279

Low

1398304

ROBO3
Roundabout homolog 3

1

0

High-throughput

0.279

Low

1428259

BSSP4
Brain-specific serine protease 4

1

0

High-throughput

0.279

Low

1446706

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.279

Low

1448429

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

0

High-throughput

0.279

Low

1448431

DKKL1
Dickkopf-like protein 1

1

0

High-throughput

0.279

Low

1448433

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.279

Low

1448439

BACE2
Beta-secretase 2

1

0

High-throughput

0.279

Low

635417

CO9A1

1

0

High-throughput

0.249

Low

1248842

ENPP6
Glycerophosphocholine cholinephosphodiesterase ENPP6

1

0

High-throughput

0.249

Low

1249242

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1369581

ATOH1
Transcription factor ATOH1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025