HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 248
+	Hs
		411315 INSR_HUMAN (1-1382): 0: 1530: 100.00		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		435554 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		435597 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		435604 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		435542 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		435553 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		435594 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Dm
		448232 INSR_DROME (30-1382): 0: 1002: 34.55		1433Z_DROME (1-245): 4.71e-99: 290: 66.12
+	Hs
		383641 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		383724 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		383732 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		169164 MUSK_HUMAN (1017-1291): 1.24e-69: 254: 42.22		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		384358 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		169169 MUSK_HUMAN (1017-1291): 1.24e-69: 254: 42.22		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		384604 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		383624 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		384623 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		384306 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		384357 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		384598 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16