HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: SERPH (P50454)
Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47)
Gene: SERPINH1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.50	0.457

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1382 Hs			1 418
+	Rn
		403561 INSR_RAT (1-1382): 0: 1527: 94.44		SPA3K_RAT (5-409): 3.49e-160: 459: 23.97
+	Hs
		435588 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		SERPH_HUMAN (1-418): 7.1e-152: 438: 100.00
+	Hs
		445832 ROS1_HUMAN (511-1377): 3.38e-158: 530: 22.63		SERPH_HUMAN (1-418): 7.1e-152: 438: 100.00
+	Hs
		839705 ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53		SERPH_HUMAN (1-418): 7.1e-152: 438: 100.00
+	Hs
		384501 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		SERPH_HUMAN (1-418): 7.1e-152: 438: 100.00
+	Hs
		384377 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		SPB6_HUMAN (43-409): 4.91e-150: 431: 29.52
+	Hs
		839599 NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43		SERPH_HUMAN (1-418): 7.1e-152: 438: 100.00
+	Hs
		839579 MERTK_HUMAN (835-1301): 1.61e-62: 234: 32.36		SERPH_HUMAN (1-418): 7.1e-152: 438: 100.00
+	Hs
		609214 FGFR3_HUMAN (1015-1287): 2.21e-62: 231: 40.78		SERPH_HUMAN (1-418): 7.1e-152: 438: 100.00
+	Hs
		674366 UFO_HUMAN (789-1294): 1.77e-61: 229: 31.09		SERPH_HUMAN (1-418): 7.1e-152: 438: 100.00