Protein: MSH2
DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2)

Gene: MSH2
Organism: Homo sapiens
Interactions: 227
UniProt ID: P43246

Gene Ontology (top 5):
GO:0000781 - chromosome, telomeric region
GO:0001701 - in utero embryonic development
GO:0002204 - somatic recombination of immunoglobulin genes involved in immune response
GO:0003677 - DNA binding
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

846568

MSH6
DNA mismatch repair protein Msh6

19

12

Small-scale

0.988

High

633299

MSH3
DNA mismatch repair protein Msh3

12

13

Small-scale

0.984

High

827341

MLH1
DNA mismatch repair protein Mlh1

7

20

Small-scale

0.951

High

846572

PMS2
Mismatch repair endonuclease PMS2

3

20

Small-scale

0.827

High

846560

MSH2
DNA mismatch repair protein Msh2

2

12

Small-scale

0.768

High

846700

EXO1
Exonuclease 1

8

6

Small-scale

0.749

High

846672

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

7

7

Small-scale

0.743

High

371399

MYC
Myc proto-oncogene protein

6

3

Small-scale

0.728

High

846634

SLX4
Structure-specific endonuclease subunit SLX4

5

2

Small-scale

0.721

High

846682

MCM9
DNA helicase MCM9

4

4

Small-scale

0.694

High

846600

ATR
Serine/threonine-protein kinase ATR

4

6

Small-scale

0.692

High

846654

OTUB1
Ubiquitin thioesterase OTUB1

4

0

Small-scale

0.667

High

846577

SUMO2
Small ubiquitin-related modifier 2

3

3

Small-scale

0.655

High

798809

BRCA1
Breast cancer type 1 susceptibility protein

3

8

Small-scale

0.647

High

413360

P53
Cellular tumor antigen p53

3

1

Small-scale

0.640

High

846689

HDAC6
Protein deacetylase HDAC6

2

3

Small-scale

0.634

High

846695

MUTYH
Adenine DNA glycosylase

2

1

Small-scale

0.629

High

846601

SNW1
SNW domain-containing protein 1

2

1

Small-scale

0.628

High

354923

CHK2
Serine/threonine-protein kinase Chk2

2

1

Small-scale

0.624

High

846646

ESR2
Estrogen receptor beta

2

2

Small-scale

0.624

High

728093

AKT1
RAC-alpha serine/threonine-protein kinase

2

1

High-throughput

0.619

High

846571

PMS1
PMS1 protein homolog 1

1

20

Small-scale

0.618

High

254338

CC14B
Dual specificity protein phosphatase CDC14B

2

5

High-throughput

0.614

High

487056

PARP1
Poly [ADP-ribose] polymerase 1

2

6

High-throughput

0.611

High

846696

MCM8
DNA helicase MCM8

2

4

Small-scale

0.611

High

400442

RAF1
RAF proto-oncogene serine/threonine-protein kinase

3

0

High-throughput

0.606

High

588117

RFA2
Replication protein A 32 kDa subunit

2

5

High-throughput

0.601

High

550910

PCNA
Proliferating cell nuclear antigen

2

6

Small-scale

0.595

High

846596

RFA4
Replication protein A 30 kDa subunit

2

5

Small-scale

0.595

High

259578

BRD4
Bromodomain-containing protein 4

2

4

High-throughput

0.584

High

694837

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

5

High-throughput

0.584

High

767612

RFA3
Replication protein A 14 kDa subunit

2

2

High-throughput

0.584

High

846567

CDK9
Cyclin-dependent kinase 9

2

1

High-throughput

0.584

High

846585

H31
Histone H3.1

2

10

High-throughput

0.584

High

846660

UHRF1
E3 ubiquitin-protein ligase UHRF1

2

5

Small-scale

0.584

High

846645

APBP2
Amyloid protein-binding protein 2

2

0

High-throughput

0.580

High

846570

BLM
RecQ-like DNA helicase BLM

2

7

Small-scale

0.571

High

253193

RAD1
Cell cycle checkpoint protein RAD1

1

2

Small-scale

0.561

High

261708

HUS1
Checkpoint protein HUS1

1

2

Small-scale

0.561

High

395649

ESR1
Estrogen receptor

1

2

Small-scale

0.561

High

846576

MAX
Protein max

1

3

Small-scale

0.561

High

846662

RAD9A
Cell cycle checkpoint control protein RAD9A

1

2

Small-scale

0.561

High

846619

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

2

High-throughput

0.552

High

144133

F16P2
Fructose-1,6-bisphosphatase isozyme 2

1

1

High-throughput

0.541

High

374453

RASH
GTPase HRas

1

1

High-throughput

0.541

High

482355

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.541

High

846697

LEF1
Lymphoid enhancer-binding factor 1

1

2

High-throughput

0.541

High

230765

EXTL3
Exostosin-like 3

1

1

High-throughput

0.536

High

729523

CASPE
Caspase-14

1

1

High-throughput

0.536

High

846593

SSRP1
FACT complex subunit SSRP1

1

4

High-throughput

0.536

High

846618

H2B2E
Histone H2B type 2-E

1

9

High-throughput

0.536

High

846630

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

2

High-throughput

0.536

High

846632

RBM45
RNA-binding protein 45

1

1

High-throughput

0.536

High

846639

ZSC18
Zinc finger and SCAN domain-containing protein 18

1

3

High-throughput

0.536

High

846640

NEK7
Serine/threonine-protein kinase Nek7

1

3

High-throughput

0.536

High

846655

AURKB
Aurora kinase B

1

2

High-throughput

0.536

High

846661

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

846675

WDR76
WD repeat-containing protein 76

1

6

High-throughput

0.536

High

846703

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

1

High-throughput

0.536

High

846706

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

1

High-throughput

0.536

High

846615

SMAD1
Mothers against decapentaplegic homolog 1

1

0

High-throughput

0.518

High

846704

ZN510
Zinc finger protein 510

1

0

High-throughput

0.518

High

277327

TP4A3
Protein tyrosine phosphatase type IVA 3

1

5

High-throughput

0.515

High

656064

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

3

High-throughput

0.515

High

846590

MECOM
Histone-lysine N-methyltransferase MECOM

1

2

High-throughput

0.515

High

846694

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.515

High

846610

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

0

Small-scale

0.513

High

275166

GGCT
Gamma-glutamylcyclotransferase

1

0

High-throughput

0.513

High

409564

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

0

High-throughput

0.513

High

538542

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

0

High-throughput

0.513

High

698463

CALX
Calnexin

1

0

High-throughput

0.513

High

846586

CBX1
Chromobox protein homolog 1

1

0

High-throughput

0.513

High

846588

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.513

High

846612

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.513

High

846603

TRI29
Tripartite motif-containing protein 29

1

3

Small-scale

0.512

High

846616

SMN
Survival motor neuron protein

1

1

High-throughput

0.508

High

648453

FGFR4
Fibroblast growth factor receptor 4

1

4

High-throughput

0.501

High

654097

XPA
DNA repair protein complementing XP-A cells

1

2

Small-scale

0.501

High

846574

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.501

High

846663

BARD1
BRCA1-associated RING domain protein 1

1

3

Small-scale

0.501

High

481142

HMGB1
High mobility group protein B1

1

2

Small-scale

0.500

High

325426

RPP14
Ribonuclease P protein subunit p14

1

0

High-throughput

0.486

High

405412

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

627933

ANXA7
Annexin A7

1

0

High-throughput

0.486

High

807976

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.486

High

710113

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.480

High

122596

UBXN8
UBX domain-containing protein 8

1

2

High-throughput

0.479

High

163067

CHK1
Serine/threonine-protein kinase Chk1

1

1

Small-scale

0.479

High

171845

ZN263
Zinc finger protein 263

1

1

Small-scale

0.479

High

187481

FANCA
Fanconi anemia group A protein

1

1

Small-scale

0.479

High

231118

AIRE
Autoimmune regulator

1

10

Small-scale

0.479

High

240996

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

247724

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

315240

RECQ4
ATP-dependent DNA helicase Q4

1

8

High-throughput

0.479

High

345484

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

349852

SNAI1
Zinc finger protein SNAI1

1

2

High-throughput

0.479

High

411530

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

415409

HSPB1
Heat shock protein beta-1

1

1

Small-scale

0.479

High

459241

CATL1
Procathepsin L

1

1

High-throughput

0.479

High

464364

ERCC1
DNA excision repair protein ERCC-1

1

2

Small-scale

0.479

High

557923

XRCC6
X-ray repair cross-complementing protein 6

1

3

Small-scale

0.479

High

591518

H2AX
Histone H2AX

1

5

Small-scale

0.479

High

606379

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

651209

CBL
E3 ubiquitin-protein ligase CBL

1

2

High-throughput

0.479

High

659391

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

667618

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.479

High

719196

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

731050

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

791156

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

799787

COIL
Coilin

1

2

High-throughput

0.479

High

846561

GATA4
Transcription factor GATA-4

1

2

High-throughput

0.479

High

846562

RECQ1
ATP-dependent DNA helicase Q1

1

7

High-throughput

0.479

High

846563

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

846564

CDK8
Cyclin-dependent kinase 8

1

3

High-throughput

0.479

High

846578

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

846580

H4
Histone H4

1

2

High-throughput

0.479

High

846581

H2B1C
Histone H2B type 1-C/E/F/G/I

1

9

High-throughput

0.479

High

846582

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.479

High

846583

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

846584

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.479

High

846587

H33
Histone H3.3

1

10

High-throughput

0.479

High

846591

KPCZ
Protein kinase C zeta type

1

3

Small-scale

0.479

High

846592

RAD51
DNA repair protein RAD51 homolog 1

1

3

Small-scale

0.479

High

846594

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.479

High

846597

TIF1B
Transcription intermediary factor 1-beta

1

6

High-throughput

0.479

High

846599

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

846602

CUL3
Cullin-3

1

1

High-throughput

0.479

High

846604

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.479

High

846605

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

5

High-throughput

0.479

High

846608

HLTF
Helicase-like transcription factor

1

9

Small-scale

0.479

High

846613

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

846617

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

High-throughput

0.479

High

846621

FTM
Protein fantom

1

1

High-throughput

0.479

High

846622

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

846623

ZN746
Zinc finger protein 746

1

2

High-throughput

0.479

High

846628

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

846635

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

Small-scale

0.479

High

846636

ZBT38
Zinc finger and BTB domain-containing protein 38

1

1

Small-scale

0.479

High

846643

DGCR8
Microprocessor complex subunit DGCR8

1

1

Small-scale

0.479

High

846644

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.479

High

846647

CBP
CREB-binding protein

1

6

Small-scale

0.479

High

846649

XPF
DNA repair endonuclease XPF

1

2

Small-scale

0.479

High

846650

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

846651

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

2

High-throughput

0.479

High

846656

CEP19
Centrosomal protein of 19 kDa

1

1

High-throughput

0.479

High

846657

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

846665

RN126
E3 ubiquitin-protein ligase RNF126

1

1

High-throughput

0.479

High

846667

FACD2
Fanconi anemia group D2 protein

1

2

Small-scale

0.479

High

846668

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

846670

AICDA
Single-stranded DNA cytosine deaminase

1

1

Small-scale

0.479

High

846674

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

846676

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

2

High-throughput

0.479

High

846677

BRD7
Bromodomain-containing protein 7

1

5

High-throughput

0.479

High

846678

ANLN
Anillin

1

1

High-throughput

0.479

High

846679

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

High-throughput

0.479

High

846683

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

846684

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

846685

DTL
Denticleless protein homolog

1

2

Small-scale

0.479

High

846690

POLK
DNA polymerase kappa

1

4

Small-scale

0.479

High

846691

REV1
DNA repair protein REV1

1

4

Small-scale

0.479

High

846692

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

846699

TRI33
E3 ubiquitin-protein ligase TRIM33

1

5

High-throughput

0.479

High

846701

SMC3
Structural maintenance of chromosomes protein 3

1

1

High-throughput

0.479

High

846702

POLH
DNA polymerase eta

1

4

Small-scale

0.479

High

846707

NEMO
NF-kappa-B essential modulator

1

1

High-throughput

0.479

High

846607

GRB7
Growth factor receptor-bound protein 7

1

1

High-throughput

0.464

High

128835

MEN1
Menin

1

0

High-throughput

0.458

High

190844

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

293339

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

385529

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

420416

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.458

High

567287

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

596858

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

Small-scale

0.458

High

616262

RCC1
Regulator of chromosome condensation

1

0

High-throughput

0.458

High

846569

TXTP
Tricarboxylate transport protein, mitochondrial

1

0

High-throughput

0.458

High

846575

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

846579

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

846606

FA50A
Protein FAM50A

1

0

High-throughput

0.458

High

846611

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

846614

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.458

High

846629

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

846637

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

846641

NELFB
Negative elongation factor B

1

0

High-throughput

0.458

High

846642

ATRIP
ATR-interacting protein

1

0

Small-scale

0.458

High

846671

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

846680

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

846681

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

846693

TES
Testin

1

0

High-throughput

0.458

High

143409

E2F3
Transcription factor E2F3

1

1

Small-scale

0.445

High

262035

NBN
Nibrin

1

1

Small-scale

0.445

High

397911

ANGI
Angiogenin

1

1

High-throughput

0.445

High

429470

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

501928

H2AZ
Histone H2A.Z

1

5

Small-scale

0.445

High

769937

RFC1
Replication factor C subunit 1

1

1

Small-scale

0.445

High

846566

MRE11
Double-strand break repair protein MRE11

1

2

Small-scale

0.445

High

846595

STK4
Serine/threonine-protein kinase 4

1

2

High-throughput

0.445

High

846598

ATM
Serine-protein kinase ATM

1

6

Small-scale

0.445

High

846609

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.445

High

846648

RAD50
DNA repair protein RAD50

1

4

Small-scale

0.445

High

846659

CEP63
Centrosomal protein of 63 kDa

1

2

High-throughput

0.445

High

846664

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

1

Small-scale

0.445

High

846666

S12A9
Solute carrier family 12 member 9

1

1

High-throughput

0.445

High

846669

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

76621

B4DZK1
cDNA FLJ50036, weakly similar to Myosin-11

1

1

High-throughput

0.439

High

846589

IFM3
Interferon-induced transmembrane protein 3

1

2

High-throughput

0.437

High

846626

LRC31
Leucine-rich repeat-containing protein 31

1

1

High-throughput

0.437

High

846627

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

846631

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

1

Small-scale

0.437

High

846653

FAF2
FAS-associated factor 2

1

2

High-throughput

0.437

High

846673

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

846698

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

626117

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.426

High

846687

CC180
Coiled-coil domain-containing protein 180

1

1

High-throughput

0.417

High

846565

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.408

High

159324

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

0

High-throughput

0.282

High

846573

STX17
Syntaxin-17

1

0

High-throughput

0.282

High

846633

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

0

High-throughput

0.282

High

846638

TDRD7
Tudor domain-containing protein 7

1

0

High-throughput

0.282

High

846658

CANB2
Calcineurin subunit B type 2

1

0

High-throughput

0.282

High

846624

SBSN
Suprabasin

1

0

High-throughput

0.279

Low

846686

CALL5
Calmodulin-like protein 5

1

0

High-throughput

0.279

Low

846620

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

846625

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

846652

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.249

Low

846688

WRP73
WD repeat-containing protein WRAP73

1

0

High-throughput

0.249

Low

846705

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025