Protein: MSH6
DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160)

Gene: MSH6
Organism: Homo sapiens
Interactions: 226
UniProt ID: P52701

Gene Ontology (top 5):
GO:0000710 - meiotic mismatch repair
GO:0000785 - chromatin
GO:0003684 - damaged DNA binding
GO:0003682 - chromatin binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

846568

MSH2
DNA mismatch repair protein Msh2

19

12

Small-scale

0.988

High

827354

MLH1
DNA mismatch repair protein Mlh1

5

20

Small-scale

0.902

High

501944

H2AZ
Histone H2A.Z

3

8

Small-scale

0.839

High

913298

H31
Histone H3.1

3

20

Small-scale

0.834

High

913288

PMS2
Mismatch repair endonuclease PMS2

3

20

Small-scale

0.827

High

913300

H33
Histone H3.3

3

20

High-throughput

0.827

High

591549

H2AX
Histone H2AX

2

9

Small-scale

0.754

High

550937

PCNA
Proliferating cell nuclear antigen

9

7

Small-scale

0.753

High

913334

H2B2E
Histone H2B type 2-E

1

14

High-throughput

0.691

High

913387

H2A1J
Histone H2A type 1-J

1

7

High-throughput

0.691

High

371532

MYC
Myc proto-oncogene protein

4

4

High-throughput

0.691

High

557976

XRCC6
X-ray repair cross-complementing protein 6

3

4

Small-scale

0.661

High

913413

MCM9
DNA helicase MCM9

3

4

Small-scale

0.656

High

798882

BRCA1
Breast cancer type 1 susceptibility protein

3

9

Small-scale

0.647

High

259665

BRD4
Bromodomain-containing protein 4

3

13

High-throughput

0.640

High

913353

SLX4
Structure-specific endonuclease subunit SLX4

3

5

Small-scale

0.640

High

277611

H2AY
Core histone macro-H2A.1

1

9

High-throughput

0.618

High

883488

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

913287

PMS1
PMS1 protein homolog 1

1

20

Small-scale

0.618

High

913291

H2B1D
Histone H2B type 1-D

1

14

High-throughput

0.618

High

913295

H2B1C
Histone H2B type 1-C/E/F/G/I

1

14

High-throughput

0.618

High

913320

CUL3
Cullin-3

2

2

High-throughput

0.611

High

913400

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

2

12

High-throughput

0.611

High

913386

BARD1
BRCA1-associated RING domain protein 1

2

3

Small-scale

0.585

High

913308

EP300
Histone acetyltransferase p300

2

14

Small-scale

0.584

High

913358

SIR6
NAD-dependent protein deacylase sirtuin-6

2

4

Small-scale

0.584

High

913312

CAF1A
Chromatin assembly factor 1 subunit A

1

5

Small-scale

0.578

High

117242

K7EK07
Histone H3

1

20

High-throughput

0.575

High

913337

H2B2F
Histone H2B type 2-F

1

14

High-throughput

0.575

High

395737

ESR1
Estrogen receptor

2

8

High-throughput

0.571

High

913286

BLM
RecQ-like DNA helicase BLM

2

7

Small-scale

0.571

High

253195

RAD1
Cell cycle checkpoint protein RAD1

1

2

Small-scale

0.561

High

261712

HUS1
Checkpoint protein HUS1

1

2

Small-scale

0.561

High

913385

RAD9A
Cell cycle checkpoint control protein RAD9A

1

2

Small-scale

0.561

High

913425

MUTYH
Adenine DNA glycosylase

1

1

Small-scale

0.561

High

913370

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.559

High

913297

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.550

High

374488

RASH
GTPase HRas

1

2

High-throughput

0.541

High

913303

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

5

High-throughput

0.541

High

166135

AIM2
Interferon-inducible protein AIM2

1

4

High-throughput

0.536

High

487117

PARP1
Poly [ADP-ribose] polymerase 1

1

11

High-throughput

0.536

High

541906

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

814493

FEN1
Flap endonuclease 1

1

7

High-throughput

0.536

High

913307

SSRP1
FACT complex subunit SSRP1

1

6

High-throughput

0.536

High

913319

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.536

High

913331

IF16
Gamma-interferon-inducible protein 16

1

4

High-throughput

0.536

High

913349

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

2

High-throughput

0.536

High

913361

RIN3
Ras and Rab interactor 3

1

1

High-throughput

0.536

High

913375

HDA11
Histone deacetylase 11

1

7

High-throughput

0.536

High

913384

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

913404

WDR76
WD repeat-containing protein 76

1

8

High-throughput

0.536

High

913407

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

8

High-throughput

0.536

High

913426

MCM8
DNA helicase MCM8

1

4

High-throughput

0.536

High

913431

EXO1
Exonuclease 1

1

7

High-throughput

0.536

High

913432

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

1

High-throughput

0.536

High

913435

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

1

High-throughput

0.536

High

913410

SIAS
N-acetylneuraminate-9-phosphate synthase

1

0

High-throughput

0.518

High

588266

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.515

High

885688

CASP4
Caspase-4

1

2

High-throughput

0.515

High

217254

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

High-throughput

0.513

High

913314

STX3
Syntaxin-3

1

0

High-throughput

0.513

High

913329

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

913333

DECR
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

1

0

High-throughput

0.513

High

913335

TATD3
Deoxyribonuclease TATDN3

1

0

High-throughput

0.513

High

913354

RUSC2
AP-4 complex accessory subunit RUSC2

1

0

High-throughput

0.513

High

913355

HROB
Homologous recombination OB-fold protein

1

0

High-throughput

0.513

High

913423

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

0

High-throughput

0.513

High

913292

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

6

High-throughput

0.501

High

913293

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.501

High

913324

SMC1A
Structural maintenance of chromosomes protein 1A

1

1

Small-scale

0.501

High

157121

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

163072

CHK1
Serine/threonine-protein kinase Chk1

1

1

Small-scale

0.479

High

171854

ZN263
Zinc finger protein 263

1

1

Small-scale

0.479

High

231124

AIRE
Autoimmune regulator

1

13

Small-scale

0.479

High

241162

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

254341

CC14B
Dual specificity protein phosphatase CDC14B

1

8

High-throughput

0.479

High

315316

RECQ4
ATP-dependent DNA helicase Q4

1

9

High-throughput

0.479

High

325744

UBR5
E3 ubiquitin-protein ligase UBR5

1

1

Small-scale

0.479

High

349883

SNAI1
Zinc finger protein SNAI1

1

2

High-throughput

0.479

High

411626

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

413456

P53
Cellular tumor antigen p53

1

2

Small-scale

0.479

High

415449

HSPB1
Heat shock protein beta-1

1

1

Small-scale

0.479

High

472546

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

536800

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

559276

XRCC5
X-ray repair cross-complementing protein 5

1

4

Small-scale

0.479

High

606477

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

620222

NUCL
Nucleolin

1

2

High-throughput

0.479

High

659412

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

694992

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

719200

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

767759

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

791202

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

799810

COIL
Coilin

1

4

High-throughput

0.479

High

830392

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

846195

MATR3
Matrin-3

1

1

High-throughput

0.479

High

851474

GATA4
Transcription factor GATA-4

1

2

High-throughput

0.479

High

854802

RECQ1
ATP-dependent DNA helicase Q1

1

7

High-throughput

0.479

High

861937

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.479

High

878818

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

883186

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

4

High-throughput

0.479

High

904487

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

913285

PLK1
Serine/threonine-protein kinase PLK1

1

2

High-throughput

0.479

High

913290

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

9

High-throughput

0.479

High

913294

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

913296

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.479

High

913299

PRKDC
DNA-dependent protein kinase catalytic subunit

1

7

Small-scale

0.479

High

913301

PO5F1
POU domain, class 5, transcription factor 1

1

3

High-throughput

0.479

High

913302

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

913304

MECOM
Histone-lysine N-methyltransferase MECOM

1

2

High-throughput

0.479

High

913305

KPCZ
Protein kinase C zeta type

1

4

Small-scale

0.479

High

913306

RAD51
DNA repair protein RAD51 homolog 1

1

4

Small-scale

0.479

High

913309

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

5

High-throughput

0.479

High

913310

FOXC1
Forkhead box protein C1

1

1

High-throughput

0.479

High

913313

TIF1B
Transcription intermediary factor 1-beta

1

8

High-throughput

0.479

High

913317

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

913318

ATR
Serine/threonine-protein kinase ATR

1

7

Small-scale

0.479

High

913322

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.479

High

913323

GRB7
Growth factor receptor-bound protein 7

1

2

Small-scale

0.479

High

913326

CUL7
Cullin-7

1

2

High-throughput

0.479

High

913327

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

913330

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

High-throughput

0.479

High

913339

RN123
E3 ubiquitin-protein ligase RNF123

1

3

High-throughput

0.479

High

913341

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

913342

ZN746
Zinc finger protein 746

1

2

High-throughput

0.479

High

913347

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

913348

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

913352

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.479

High

913357

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

2

High-throughput

0.479

High

913359

ZBT38
Zinc finger and BTB domain-containing protein 38

1

3

Small-scale

0.479

High

913363

FBX25
F-box only protein 25

1

1

High-throughput

0.479

High

913364

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

5

High-throughput

0.479

High

913365

DGCR8
Microprocessor complex subunit DGCR8

1

2

Small-scale

0.479

High

913366

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

Small-scale

0.479

High

913368

CBP
CREB-binding protein

1

11

Small-scale

0.479

High

913373

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

2

High-throughput

0.479

High

913377

SPDLY
Protein Spindly

1

1

High-throughput

0.479

High

913378

AURKB
Aurora kinase B

1

4

High-throughput

0.479

High

913379

CEP19
Centrosomal protein of 19 kDa

1

1

High-throughput

0.479

High

913380

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

913382

RUFY1
RUN and FYVE domain-containing protein 1

1

3

High-throughput

0.479

High

913383

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

8

Small-scale

0.479

High

913390

RN126
E3 ubiquitin-protein ligase RNF126

1

1

High-throughput

0.479

High

913391

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

High-throughput

0.479

High

913395

WWTR1
WW domain-containing transcription regulator protein 1

1

4

High-throughput

0.479

High

913396

AICDA
Single-stranded DNA cytosine deaminase

1

1

Small-scale

0.479

High

913402

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

913403

BRD9
Bromodomain-containing protein 9

1

6

High-throughput

0.479

High

913409

ANLN
Anillin

1

2

High-throughput

0.479

High

913411

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

4

High-throughput

0.479

High

913414

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

1

High-throughput

0.479

High

913415

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

913416

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

913417

DTL
Denticleless protein homolog

1

5

Small-scale

0.479

High

913418

HDAC6
Protein deacetylase HDAC6

1

6

Small-scale

0.479

High

913419

KS6B2
Ribosomal protein S6 kinase beta-2

1

2

High-throughput

0.479

High

913420

POLK
DNA polymerase kappa

1

4

Small-scale

0.479

High

913421

MO4L1
Mortality factor 4-like protein 1

1

1

Small-scale

0.479

High

913422

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

913424

PARP2
Poly [ADP-ribose] polymerase 2

1

6

High-throughput

0.479

High

913428

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

913429

CC14A
Dual specificity protein phosphatase CDC14A

1

8

High-throughput

0.479

High

913430

TRI33
E3 ubiquitin-protein ligase TRIM33

1

7

High-throughput

0.479

High

913433

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

194069

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

664693

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.458

High

913289

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.458

High

913315

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.458

High

913332

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.458

High

913336

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

913344

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

913351

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

913367

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

913388

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

913397

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

913405

CLSPN
Claspin

1

0

Small-scale

0.458

High

913408

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

108010

G3V167
Poly [ADP-ribose] polymerase

1

6

High-throughput

0.445

High

143415

E2F3
Transcription factor E2F3

1

1

Small-scale

0.445

High

262044

NBN
Nibrin

1

1

Small-scale

0.445

High

327875

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.445

High

354608

PAK4
Serine/threonine-protein kinase PAK 4

1

2

High-throughput

0.445

High

397919

ANGI
Angiogenin

1

1

High-throughput

0.445

High

675425

TYY1
Transcriptional repressor protein YY1

1

1

Small-scale

0.445

High

769953

RFC1
Replication factor C subunit 1

1

1

Small-scale

0.445

High

892826

MRE11
Double-strand break repair protein MRE11

1

2

Small-scale

0.445

High

913311

STK4
Serine/threonine-protein kinase 4

1

3

High-throughput

0.445

High

913316

ATM
Serine-protein kinase ATM

1

7

Small-scale

0.445

High

913325

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.445

High

913338

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

913369

RAD50
DNA repair protein RAD50

1

5

Small-scale

0.445

High

913389

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

2

Small-scale

0.445

High

913394

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

913399

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

1

High-throughput

0.445

High

913321

TRI29
Tripartite motif-containing protein 29

1

3

Small-scale

0.437

High

913343

LRC31
Leucine-rich repeat-containing protein 31

1

2

High-throughput

0.437

High

913345

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

913350

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

1

High-throughput

0.437

High

913374

FAF2
FAS-associated factor 2

1

2

High-throughput

0.437

High

913393

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.437

High

913401

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

913427

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

High-throughput

0.437

High

344140

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

913356

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

913381

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

913412

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.426

High

886660

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.408

High

104125

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

178543

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

1

High-throughput

0.407

High

913392

S12A9
Solute carrier family 12 member 9

1

1

High-throughput

0.407

High

249283

BRNP1
BMP/retinoic acid-inducible neural-specific protein 1

1

0

High-throughput

0.279

Low

913328

P2RY6
P2Y purinoceptor 6

1

0

High-throughput

0.279

Low

913362

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

913371

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.279

Low

913376

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

913398

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

913406

ZDBF2
DBF4-type zinc finger-containing protein 2

1

0

High-throughput

0.279

Low

913434

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

353130

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.269

Low

576630

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.249

Low

705689

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

0

High-throughput

0.249

Low

913346

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

Small-scale

0.249

Low

913372

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.249

Low

982

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

653206

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

913340

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

0

Small-scale

0.232

Low

913360

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025