HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.981

Property	Details
Experiments	8621530, 7479769, 9506989, 35384245, 12551896, 9369444, 10871840, 9006901, 15664450, 19648926, 12493740
Identification Methods	two hybrid, affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein three hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~fn3, BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0008286 - insulin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 594
+	Rn
		292434 T2CB11_RAT (1-1382): 0: 1538: 94.87		GRB14_RAT (76-594): 0: 584: 53.06
+	Rn
		292431 INSR_RAT (1-1382): 0: 1527: 94.44		GRB14_RAT (76-594): 0: 584: 53.06
+	Hs
		411383 INSR_HUMAN (1-1382): 0: 1530: 100.00		GRB14_HUMAN (76-594): 0: 575: 55.08
+	Hs
		435632 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		GRB10_HUMAN (1-594): 0: 712: 100.00
+	Hs
		411384 INSR_HUMAN (1-1382): 0: 1530: 100.00		GRB7_HUMAN (107-594): 1.36e-174: 507: 55.60
+	Hs
		411288 INSR_HUMAN (1-1382): 0: 1530: 100.00		VAV_HUMAN (36-594): 3.93e-139: 426: 14.11
+	Hs
		435642 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		GRB14_HUMAN (76-594): 0: 575: 55.08
+	Hs
		411523 INSR_HUMAN (1-1382): 0: 1530: 100.00		VAV3_HUMAN (37-592): 1.1e-99: 323: 12.20
+	Hs
		145966 INSR_HUMAN (1-1382): 0: 1530: 100.00		SH2B2_HUMAN (301-581): 7.5e-55: 198: 16.29
+	Mm
		546279 INSR_MOUSE (1-1382): 0: 1509: 94.36		SH2B2_MOUSE (303-581): 4.88e-50: 185: 16.07
+	Mm
		403410 INSR_MOUSE (1-1382): 0: 1509: 94.36		SRC_MOUSE (443-590): 1.24e-46: 173: 22.08
+	Hs
		435801 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		VAV3_HUMAN (37-592): 1.1e-99: 323: 12.20
+	Hs
		411329 INSR_HUMAN (1-1382): 0: 1530: 100.00		CSK_HUMAN (454-587): 2.23e-26: 114: 23.19
+	Hs
		411352 INSR_HUMAN (1-1382): 0: 1530: 100.00		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Mm
		546274 INSR_MOUSE (1-1382): 0: 1509: 94.36		GRB10_MOUSE (57-148): 3.15e-14: 77.6: 69.15
+	Hs
		435518 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08
+	Hs
		433523 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		LYN_HUMAN (409-593): 7.45e-46: 171: 17.19
+	Hs
		435573 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		MATK_HUMAN (454-587): 1.29e-36: 144: 26.81
+	Hs
		435570 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		CSK_HUMAN (454-587): 2.23e-26: 114: 23.19
+	Hs
		435602 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89