Protein: RPA1
DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194)

Gene: RPA1, POLR1A
Organism: Homo sapiens
Interactions: 175
UniProt ID: O95602

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0003899 - DNA-directed RNA polymerase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

340037

RPA2
DNA-directed RNA polymerase I subunit RPA2

11

20

Small-scale

0.975

High

339934

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

7

15

Small-scale

0.970

High

180196

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

7

19

Small-scale

0.968

High

340029

RPA49
DNA-directed RNA polymerase I subunit RPA49

8

3

Small-scale

0.968

High

339960

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

6

10

Small-scale

0.943

High

339964

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

5

10

Small-scale

0.927

High

339987

RPA43
DNA-directed RNA polymerase I subunit RPA43

4

1

High-throughput

0.903

High

339962

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

4

9

Small-scale

0.895

High

340048

RPA12
DNA-directed RNA polymerase I subunit RPA12

4

20

Small-scale

0.895

High

340047

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

4

2

Small-scale

0.881

High

339926

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

4

11

Small-scale

0.840

High

243494

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

2

8

Small-scale

0.754

High

339969

ERCC6
DNA excision repair protein ERCC-6

2

12

Small-scale

0.754

High

190779

RPA34
DNA-directed RNA polymerase I subunit RPA34

6

3

Small-scale

0.732

High

339967

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

5

11

Small-scale

0.712

High

339997

SPT6H
Transcription elongation factor SPT6

1

5

High-throughput

0.691

High

316334

RMP
Unconventional prefoldin RPB5 interactor 1

4

3

Small-scale

0.686

High

340041

SIR7
NAD-dependent protein deacetylase sirtuin-7

4

5

Small-scale

0.676

High

340001

SKAP1
Src kinase-associated phosphoprotein 1

3

5

High-throughput

0.667

High

340051

UXT
Protein UXT

3

2

High-throughput

0.667

High

339988

TAF1B
TATA box-binding protein-associated factor RNA polymerase I subunit B

1

0

High-throughput

0.656

High

340045

PIHD1
PIH1 domain-containing protein 1

5

3

High-throughput

0.656

High

339931

UBF1
Nucleolar transcription factor 1

3

4

Small-scale

0.640

High

340035

RPAP3
RNA polymerase II-associated protein 3

4

6

High-throughput

0.633

High

340039

GPN1
GPN-loop GTPase 1

2

9

High-throughput

0.628

High

164991

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

11

High-throughput

0.618

High

192771

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

8

High-throughput

0.618

High

287426

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

4

High-throughput

0.618

High

339933

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

19

High-throughput

0.618

High

339940

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

11

High-throughput

0.618

High

339944

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

20

High-throughput

0.618

High

339949

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

20

High-throughput

0.618

High

339961

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

11

High-throughput

0.618

High

339965

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

12

High-throughput

0.618

High

339979

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

8

Small-scale

0.618

High

340004

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

3

High-throughput

0.618

High

340044

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

20

High-throughput

0.618

High

340067

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

20

High-throughput

0.618

High

340068

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

12

High-throughput

0.618

High

339968

CSK21
Casein kinase II subunit alpha

2

10

Small-scale

0.611

High

340036

WDR76
WD repeat-containing protein 76

2

9

High-throughput

0.611

High

340056

PFD2
Prefoldin subunit 2

2

3

High-throughput

0.611

High

340057

GPN3
GPN-loop GTPase 3

3

9

High-throughput

0.609

High

339959

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

0

High-throughput

0.585

High

91731

C9JLU1
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

10

High-throughput

0.575

High

339929

ITF2
Transcription factor 4

1

1

High-throughput

0.573

High

339917

ESR1
Estrogen receptor

2

5

High-throughput

0.571

High

339930

RFA2
Replication protein A 32 kDa subunit

2

2

High-throughput

0.571

High

339974

SKP2
S-phase kinase-associated protein 2

1

1

Small-scale

0.561

High

339978

NOLC1
Nucleolar and coiled-body phosphoprotein 1

2

0

Small-scale

0.559

High

340026

MBB1A
Myb-binding protein 1A

2

0

Small-scale

0.559

High

182067

PFD6
Prefoldin subunit 6

2

3

High-throughput

0.558

High

340022

DAA10
Dynein axonemal assembly factor 10

2

2

High-throughput

0.558

High

340042

PDRG1
p53 and DNA damage-regulated protein 1

2

2

High-throughput

0.558

High

339970

REL
Proto-oncogene c-Rel

1

0

High-throughput

0.549

High

339935

CSK22
Casein kinase II subunit alpha'

1

12

High-throughput

0.536

High

339945

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

339946

CADH5
Cadherin-5

1

1

High-throughput

0.536

High

339955

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.536

High

339972

SSRP1
FACT complex subunit SSRP1

1

11

Small-scale

0.536

High

339986

MK06
Mitogen-activated protein kinase 6

1

6

High-throughput

0.536

High

340016

TRI52
E3 ubiquitin-protein ligase TRIM52

1

2

High-throughput

0.536

High

340063

RUVB2
RuvB-like 2

1

9

High-throughput

0.536

High

340064

RUVB1
RuvB-like 1

1

9

High-throughput

0.536

High

340069

SP16H
FACT complex subunit SPT16

1

2

Small-scale

0.536

High

339914

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

2

High-throughput

0.533

High

339992

A16L1
Autophagy-related protein 16-1

2

7

High-throughput

0.521

High

339994

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

104047

F5H148
RRN3 homolog, RNA polymerase I transcription factor

1

2

High-throughput

0.514

High

339982

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

1

0

High-throughput

0.513

High

340033

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

1

0

High-throughput

0.513

High

340053

TRI10
Tripartite motif-containing protein 10

1

0

High-throughput

0.513

High

340055

PP13
Galactoside-binding soluble lectin 13

1

0

High-throughput

0.513

High

339963

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

High-throughput

0.501

High

339918

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

Small-scale

0.500

High

340058

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

340017

RMC1
Regulator of MON1-CCZ1 complex

1

1

High-throughput

0.489

High

340034

ASB7
Ankyrin repeat and SOCS box protein 7

1

2

High-throughput

0.489

High

340049

NHSL3
NHS-like protein 3

1

5

High-throughput

0.489

High

340052

FBLN5
Fibulin-5

1

2

High-throughput

0.489

High

339957

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

261990

NBN
Nibrin

1

0

Small-scale

0.479

High

156808

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

259262

BRD4
Bromodomain-containing protein 4

1

11

High-throughput

0.479

High

316238

RECQ5
ATP-dependent DNA helicase Q5

1

10

Small-scale

0.479

High

339916

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

339919

H2A1B
Histone H2A type 1-B/E

1

6

High-throughput

0.479

High

339920

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

3

High-throughput

0.479

High

339924

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

339928

SRC
Proto-oncogene tyrosine-protein kinase Src

1

3

High-throughput

0.479

High

339936

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

High-throughput

0.479

High

339937

SCP2
Sterol carrier protein 2

1

1

High-throughput

0.479

High

339939

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

High-throughput

0.479

High

339942

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

339947

H2B1B
Histone H2B type 1-B

1

11

High-throughput

0.479

High

339948

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

339950

BRCA1
Breast cancer type 1 susceptibility protein

1

4

Small-scale

0.479

High

339951

TEC
Tyrosine-protein kinase Tec

1

3

High-throughput

0.479

High

339952

RECQ1
ATP-dependent DNA helicase Q1

1

9

High-throughput

0.479

High

339954

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

339958

CDK7
Cyclin-dependent kinase 7

1

8

High-throughput

0.479

High

339966

H4
Histone H4

1

4

High-throughput

0.479

High

339971

CSTF1
Cleavage stimulation factor subunit 1

1

5

Small-scale

0.479

High

339973

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

339975

TCOF
Treacle protein

1

3

Small-scale

0.479

High

339976

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

339977

DX39B
Spliceosome RNA helicase DDX39B

1

8

High-throughput

0.479

High

339980

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.479

High

339991

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

10

High-throughput

0.479

High

339996

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

340005

SIR6
NAD-dependent protein deacylase sirtuin-6

1

5

High-throughput

0.479

High

340011

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

340012

KAT6A
Histone acetyltransferase KAT6A

1

3

High-throughput

0.479

High

340013

KAT2B
Histone acetyltransferase KAT2B

1

8

Small-scale

0.479

High

340014

FBXW7
F-box/WD repeat-containing protein 7

1

5

High-throughput

0.479

High

340023

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

15

High-throughput

0.479

High

340024

RING2
E3 ubiquitin-protein ligase RING2

1

4

High-throughput

0.479

High

340025

BARD1
BRCA1-associated RING domain protein 1

1

2

Small-scale

0.479

High

340030

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

340040

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

17

High-throughput

0.479

High

340043

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

3

High-throughput

0.479

High

340050

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.479

High

340054

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

340065

NUDC
Nuclear migration protein nudC

1

1

High-throughput

0.479

High

340066

NOP58
Nucleolar protein 58

1

3

Small-scale

0.479

High

247582

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

339915

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.458

High

339981

TAF13
Transcription initiation factor TFIID subunit 13

1

0

High-throughput

0.458

High

339998

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

340010

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

339925

RPC22
Protein POLR1D, isoform 2

1

1

High-throughput

0.445

High

339927

RARA
Retinoic acid receptor alpha

1

5

Small-scale

0.445

High

339938

XPA
DNA repair protein complementing XP-A cells

1

2

High-throughput

0.445

High

339956

DNLI3
DNA ligase 3

1

1

High-throughput

0.445

High

340002

S13A5
Na(+)/citrate cotransporter

1

2

High-throughput

0.445

High

340060

AGO1
Protein argonaute-1

1

6

High-throughput

0.445

High

271790

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.437

High

339921

YES
Tyrosine-protein kinase Yes

1

3

High-throughput

0.437

High

339922

LYN
Tyrosine-protein kinase Lyn

1

3

High-throughput

0.437

High

339932

TCPA
T-complex protein 1 subunit alpha

1

3

High-throughput

0.437

High

339984

IKBB
NF-kappa-B inhibitor beta

1

1

High-throughput

0.437

High

339993

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

2

High-throughput

0.437

High

340008

FBX22
F-box only protein 22

1

1

High-throughput

0.437

High

340021

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.437

High

340027

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.437

High

340028

YTHD1
YTH domain-containing family protein 1

1

1

High-throughput

0.437

High

340032

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

340059

FBW1B
F-box/WD repeat-containing protein 11

1

6

High-throughput

0.437

High

340061

HECD1
E3 ubiquitin-protein ligase HECTD1

1

7

High-throughput

0.437

High

340062

ALK
ALK tyrosine kinase receptor

1

2

High-throughput

0.437

High

339999

SL9B2
Sodium/hydrogen exchanger 9B2

1

0

High-throughput

0.426

High

340003

APLF
Aprataxin and PNK-like factor

1

0

High-throughput

0.426

High

340006

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

0

High-throughput

0.426

High

327713

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.407

High

339985

UT2
Urea transporter 2

1

1

High-throughput

0.407

High

340000

Q86V94
LOC554223 protein

2

0

High-throughput

0.318

High

340019

DYDC2
DPY30 domain-containing protein 2

2

0

High-throughput

0.316

High

258541

DIAP2
Protein diaphanous homolog 2

1

0

High-throughput

0.279

Low

339941

CRBB3
Beta-crystallin B3

1

0

High-throughput

0.279

Low

339943

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.279

Low

339953

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

339983

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.279

Low

339989

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.279

Low

339990

FAXC
Failed axon connections homolog

1

0

High-throughput

0.279

Low

340007

TEX19
Testis-expressed protein 19

1

0

High-throughput

0.279

Low

340015

SNX21
Sorting nexin-21

1

0

High-throughput

0.279

Low

340020

TET5A
Terminal nucleotidyltransferase 5A

1

0

High-throughput

0.279

Low

340038

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.279

Low

339923

CLCA
Clathrin light chain A

1

0

High-throughput

0.269

Low

164209

NRP1
Neuropilin-1

1

0

High-throughput

0.249

Low

339995

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

340009

KBTB8
Kelch repeat and BTB domain-containing protein 8

1

0

Small-scale

0.249

Low

340018

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

340031

ATG5
Autophagy protein 5

1

0

High-throughput

0.249

Low

340046

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025