HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: SNX1 (Q13596)
Sorting nexin-1
Gene: SNX1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	9819414
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005764 - lysosome GO:0010008 - endosome membrane GO:0016020 - membrane GO:0031623 - receptor internalization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 522
+	Hs
		240332 INSR_HUMAN (1-1382): 0: 1530: 100.00		SNX2_HUMAN (10-522): 3.61e-127: 382: 58.95
+	Rn
		71355 INSR_RAT (1-1382): 0: 1527: 94.44		B2RYP4_RAT (10-522): 8.39e-125: 376: 58.95
+	Mm
		546277 INSR_MOUSE (1-1382): 0: 1509: 94.36		SNX9_MOUSE (4-518): 6.29e-96: 304: 13.88
+	Hs
		435636 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		SNX1_HUMAN (1-522): 8.2e-149: 438: 100.00
+	Hs
		307875 INSR_HUMAN (1-1382): 0: 1530: 100.00		SNX4_HUMAN (95-516): 2.25e-75: 246: 14.75
+	Hs
		411539 INSR_HUMAN (1-1382): 0: 1530: 100.00		SNX5_HUMAN (142-520): 9.13e-75: 243: 21.45
+	Hs
		411527 INSR_HUMAN (1-1382): 0: 1530: 100.00		SNX6_HUMAN (145-520): 1.81e-73: 240: 20.46
+	Hs
		240333 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		SNX2_HUMAN (10-522): 3.61e-127: 382: 58.95
+	Mm
		1141340 IGF1R_MOUSE (19-1380): 0: 1351: 54.72		SNX9_MOUSE (4-518): 6.29e-96: 304: 13.88
+	Rn
		69429 INSR_RAT (1-1382): 0: 1527: 94.44		B0BMY2_RAT (118-249): 1.83e-34: 128: 25.00
+	Hs
		435813 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		SNX5_HUMAN (142-520): 9.13e-75: 243: 21.45
+	Hs
		435805 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		SNX6_HUMAN (145-520): 1.81e-73: 240: 20.46
+	Hs
		240370 EPHA5_HUMAN (567-1319): 1.23e-176: 555: 20.98		SNX2_HUMAN (10-522): 3.61e-127: 382: 58.95
+	Hs
		872507 EPHA5_HUMAN (567-1319): 1.23e-176: 555: 20.98		SNX6_HUMAN (145-520): 1.81e-73: 240: 20.46
+	Hs
		445888 ROS1_HUMAN (511-1377): 3.38e-158: 530: 22.63		SNX5_HUMAN (142-520): 9.13e-75: 243: 21.45
+	Hs
		384801 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		SNX1_HUMAN (1-522): 8.2e-149: 438: 100.00
+	Hs
		240327 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		SNX2_HUMAN (10-522): 3.61e-127: 382: 58.95
+	Hs
		384051 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		SNX9_HUMAN (2-518): 1.33e-93: 298: 14.58
+	Hs
		385804 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		SNX9_HUMAN (2-518): 1.33e-93: 298: 14.58
+	Hs
		1081648 NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43		SNX7_HUMAN (114-515): 3.23e-86: 273: 19.65