HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: ESYT1 (Q9BSJ8)
Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein)
Gene: ESYT1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1382 Hs			1 1104
+	Hs
		435743 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		ESYT1_HUMAN (1-1104): 0: 874: 100.00
+	Hs
		872481 EPHA5_HUMAN (567-1319): 1.23e-176: 555: 20.98		ESYT1_HUMAN (1-1104): 0: 874: 100.00
+	Hs
		665519 EPHA8_HUMAN (644-1322): 3.66e-168: 531: 20.68		ESYT1_HUMAN (1-1104): 0: 874: 100.00
+	Hs
		445875 ROS1_HUMAN (511-1377): 3.38e-158: 530: 22.63		ESYT1_HUMAN (1-1104): 0: 874: 100.00
+	Hs
		1311450 ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53		ESYT1_HUMAN (1-1104): 0: 874: 100.00
+	Hs
		385434 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		ESYT1_HUMAN (1-1104): 0: 874: 100.00
+	Hs
		1081587 NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43		ESYT1_HUMAN (1-1104): 0: 874: 100.00
+	Hs
		674516 UFO_HUMAN (789-1294): 1.77e-61: 229: 31.09		ESYT1_HUMAN (1-1104): 0: 874: 100.00
+	Hs
		48271 EPHA2_HUMAN (674-1320): 4.56e-172: 540: 21.91		ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32
+	Hs
		135758 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		P3C2B_HUMAN (948-1095): 4.64e-14: 79.3: 37.50
+	Hs
		128795 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		P3C2A_HUMAN (973-1095): 9.86e-10: 65.1: 35.48
+	Hs
		385753 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		RP3A_HUMAN (311-433): 7.58e-21: 100: 16.79
+	Hs
		135759 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		P3C2B_HUMAN (948-1095): 4.64e-14: 79.3: 37.50
+	Hs
		48227 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32
+	Hs
		201879 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		RASL2_HUMAN (480-733): 5.3e-11: 68.9: 26.15
+	Hs
		128796 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		P3C2A_HUMAN (973-1095): 9.86e-10: 65.1: 35.48
+	Hs
		48274 UFO_HUMAN (789-1294): 1.77e-61: 229: 31.09		ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32
+	Hs
		201881 ERBB3_HUMAN (33-369): 1.76e-27: 123: 20.11		RASL2_HUMAN (480-733): 5.3e-11: 68.9: 26.15