HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	14583609
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 2555
+	Hs
		433637 LYN_HUMAN (1-509): 0: 582: 62.72		NOTC1_HUMAN (20-2555): 0: 1387: 100.00
+	Hs
		337391 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		NOTC1_HUMAN (20-2555): 0: 1387: 100.00
+	Hs
		337591 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		NOTC3_HUMAN (1-2014): 0: 679: 27.54
+	Hs
		411697 LCK_HUMAN (1-509): 0: 661: 100.00		ANK3_HUMAN (1572-2114): 5.09e-98: 358: 17.60
+	Hs
		433701 LYN_HUMAN (1-509): 0: 582: 62.72		ANK2_HUMAN (1662-2151): 4.82e-101: 367: 16.67
+	Hs
		433730 LYN_HUMAN (1-509): 0: 582: 62.72		ANK3_HUMAN (1572-2114): 5.09e-98: 358: 17.60
+	Hs
		434072 LYN_HUMAN (1-509): 0: 582: 62.72		ANR50_HUMAN (1862-2553): 1.06e-91: 332: 15.85
+	Hs
		411684 LCK_HUMAN (1-509): 0: 661: 100.00		NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77
+	Hs
		412196 FYN_HUMAN (30-507): 0: 586: 59.01		LTBP2_HUMAN (4-596): 1.9e-24: 115: 20.27
+	Hs
		433715 LYN_HUMAN (1-509): 0: 582: 62.72		NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77
+	Hs
		337475 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		LTBP2_HUMAN (4-596): 1.9e-24: 115: 20.27