HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33742100
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 2414
+	Hs
		522942 SRC_HUMAN (20-507): 0: 586: 55.00		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Mm
		70886 SRC_MOUSE (28-507): 0: 583: 57.05		EP300_MOUSE (1-2414): 0: 1090: 93.01
+	Hs
		996554 ITK_HUMAN (7-500): 1.08e-177: 515: 33.33		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		411582 LCK_HUMAN (1-509): 0: 661: 100.00		MUC1_HUMAN (1949-2412): 4.52e-13: 77.5: 9.23
+	Hs
		203198 LCK_HUMAN (1-509): 0: 661: 100.00		SYNJ1_HUMAN (18-469): 8.19e-10: 66.6: 13.21
+	Hs
		337613 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89
+	Hs
		433587 LYN_HUMAN (1-509): 0: 582: 62.72		BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20
+	Hs
		442866 HCK_HUMAN (1-509): 0: 602: 65.04		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		522749 SRC_HUMAN (20-507): 0: 586: 55.00		MUC1_HUMAN (1949-2412): 4.52e-13: 77.5: 9.23
+	Hs
		433560 LYN_HUMAN (1-509): 0: 582: 62.72		MUC1_HUMAN (1949-2412): 4.52e-13: 77.5: 9.23
+	Hs
		297808 LYN_HUMAN (1-509): 0: 582: 62.72		K0754_HUMAN (66-444): 1.97e-12: 75.5: 10.28
+	Hs
		433921 LYN_HUMAN (1-509): 0: 582: 62.72		PHIP_HUMAN (1068-1157): 6.78e-12: 73.6: 42.86
+	Hs
		523092 SRC_HUMAN (20-507): 0: 586: 55.00		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Mm
		101424 LYN_MOUSE (1-509): 0: 585: 62.33		F8VPR5_MOUSE (1752-2401): 7.8e-10: 67.1: 12.31
+	Hs
		433930 LYN_HUMAN (1-509): 0: 582: 62.72		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		337335 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		MUC1_HUMAN (1949-2412): 4.52e-13: 77.5: 9.23