HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: DLG1 (Q12959)
Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)
Gene: DLG1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.747

Property	Details
Experiments	9341123
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, Guanylate_kin~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0001772 - immunological synapse GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0045121 - membrane raft GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 904
+	Mm
		411930 LCK_MOUSE (1-509): 0: 657: 96.86		DLG1_MOUSE (1-904): 0: 720: 95.47
+	Hs
		433731 LYN_HUMAN (1-509): 0: 582: 62.72		DLG1_HUMAN (1-904): 0: 725: 100.00
+	Hs
		434043 LYN_HUMAN (1-509): 0: 582: 62.72		PALS2_HUMAN (421-899): 2.36e-108: 346: 23.48
+	Hs
		411718 LCK_HUMAN (1-509): 0: 661: 100.00		SCRIB_HUMAN (217-396): 1.59e-23: 109: 41.49
+	Hs
		411800 LCK_HUMAN (1-509): 0: 661: 100.00		DLG5_HUMAN (202-404): 4.58e-19: 95.5: 32.02
+	Hs
		411753 LCK_HUMAN (1-509): 0: 661: 100.00		MPP7_HUMAN (96-459): 7.98e-17: 86.8: 14.80
+	Hs
		159139 HCK_HUMAN (1-509): 0: 602: 65.04		CSKP_HUMAN (19-360): 4.23e-28: 124: 10.64
+	Hs
		159138 LYN_HUMAN (1-509): 0: 582: 62.72		CSKP_HUMAN (19-360): 4.23e-28: 124: 10.64
+	Hs
		412128 FYN_HUMAN (30-507): 0: 586: 59.01		DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64
+	Mm
		403445 SRC_MOUSE (28-507): 0: 583: 57.05		DLG4_MOUSE (86-477): 2.03e-24: 111: 16.07
+	Hs
		433758 LYN_HUMAN (1-509): 0: 582: 62.72		SCRIB_HUMAN (217-396): 1.59e-23: 109: 41.49
+	Rn
		73322 SRC_RAT (27-507): 0: 584: 56.73		PALS1_RAT (1-397): 5.96e-21: 100: 14.74
+	Hs
		433909 LYN_HUMAN (1-509): 0: 582: 62.72		DLG5_HUMAN (202-404): 4.58e-19: 95.5: 32.02
+	Hs
		433812 LYN_HUMAN (1-509): 0: 582: 62.72		MPP7_HUMAN (96-459): 7.98e-17: 86.8: 14.80
+	Hs
		433697 LYN_HUMAN (1-509): 0: 582: 62.72		EM55_HUMAN (161-314): 1.14e-14: 79.5: 14.56
+	Hs
		522978 SRC_HUMAN (20-507): 0: 586: 55.00		MPP2_HUMAN (134-320): 5.48e-13: 74.9: 16.84