Protein: LTK
Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)

Gene: LTK
Organism: Homo sapiens
Interactions: 147
UniProt ID: P29376

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

699601

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

3

20

Small-scale

0.861

High

711241

SHC1
SHC-transforming protein 1

2

20

Small-scale

0.789

High

711865

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.789

High

618990

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

20

Small-scale

0.754

High

711956

ALK
ALK tyrosine kinase receptor

2

19

Small-scale

0.737

High

711907

ALKL1
ALK and LTK ligand 1

1

3

Small-scale

0.734

High

362827

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.724

High

611001

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

20

Small-scale

0.724

High

710078

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.715

High

711906

ALKL2
ALK and LTK ligand 2

1

3

High-throughput

0.691

High

711875

ACK1
Activated CDC42 kinase 1

1

20

Small-scale

0.665

High

711930

LMTK3
Serine/threonine-protein kinase LMTK3

1

19

High-throughput

0.646

High

136304

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.618

High

711899

CDC37
Hsp90 co-chaperone Cdc37

1

20

High-throughput

0.618

High

154422

SH2B2
SH2B adapter protein 2

1

20

High-throughput

0.618

High

400336

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

Small-scale

0.618

High

683780

MOES
Moesin

1

20

High-throughput

0.618

High

711858

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

711859

RAB8A
Ras-related protein Rab-8A

1

14

High-throughput

0.618

High

711871

DYST
Dystonin

1

20

High-throughput

0.618

High

711873

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

High-throughput

0.618

High

711881

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

20

High-throughput

0.618

High

711883

LIPA1
Liprin-alpha-1

1

17

High-throughput

0.618

High

711885

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.618

High

711909

PKHM3
Pleckstrin homology domain-containing family M member 3

1

1

High-throughput

0.618

High

711931

ERBIN
Erbin

1

20

High-throughput

0.618

High

711923

RAB1C
Putative Ras-related protein Rab-1C

1

14

High-throughput

0.575

High

711908

MPRIP
Myosin phosphatase Rho-interacting protein

1

20

High-throughput

0.553

High

711921

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

20

High-throughput

0.553

High

711939

RAB1B
Ras-related protein Rab-1B

1

14

High-throughput

0.553

High

711900

DUS6
Dual specificity protein phosphatase 6

1

20

High-throughput

0.541

High

542347

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

711853

DHB4
Peroxisomal multifunctional enzyme type 2

1

5

High-throughput

0.536

High

711862

ABCE1
ATP-binding cassette sub-family E member 1

1

9

High-throughput

0.536

High

711872

NOTC2
Neurogenic locus notch homolog protein 2

1

20

High-throughput

0.536

High

711887

DX39B
Spliceosome RNA helicase DDX39B

1

9

High-throughput

0.536

High

711888

DSG2
Desmoglein-2

1

20

High-throughput

0.536

High

711928

DDX27
Probable ATP-dependent RNA helicase DDX27

1

12

High-throughput

0.536

High

711944

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.536

High

711947

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.536

High

651173

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.501

High

345410

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.500

High

417960

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

5

High-throughput

0.500

High

486990

PARP1
Poly [ADP-ribose] polymerase 1

1

11

High-throughput

0.500

High

711851

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

5

High-throughput

0.500

High

711860

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

9

High-throughput

0.500

High

711861

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

9

High-throughput

0.500

High

711876

DHX9
ATP-dependent RNA helicase A

1

13

High-throughput

0.500

High

711927

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

20

High-throughput

0.500

High

711915

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

1

3

High-throughput

0.494

High

277568

H2AY
Core histone macro-H2A.1

1

5

High-throughput

0.489

High

627598

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

7

High-throughput

0.489

High

711854

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

14

High-throughput

0.489

High

711863

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.489

High

711864

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

2

High-throughput

0.489

High

711878

SSRP1
FACT complex subunit SSRP1

1

10

High-throughput

0.489

High

711879

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

11

High-throughput

0.489

High

711884

SRSF9
Serine/arginine-rich splicing factor 9

1

14

High-throughput

0.489

High

711889

SAFB2
Scaffold attachment factor B2

1

17

High-throughput

0.489

High

711895

IPYR
Inorganic pyrophosphatase

1

2

High-throughput

0.489

High

711897

SAFB1
Scaffold attachment factor B1

1

15

High-throughput

0.489

High

711904

ZN326
DBIRD complex subunit ZNF326

1

5

High-throughput

0.489

High

711929

RBM14
RNA-binding protein 14

1

17

High-throughput

0.489

High

711935

RM01
Large ribosomal subunit protein uL1m

1

1

High-throughput

0.489

High

711943

SFXN1
Sideroflexin-1

1

4

High-throughput

0.489

High

711961

SP16H
FACT complex subunit SPT16

1

6

High-throughput

0.489

High

124740

AIP
AH receptor-interacting protein

1

19

High-throughput

0.479

High

162787

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

20

High-throughput

0.479

High

169451

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

20

High-throughput

0.479

High

239741

PCDH7
Protocadherin-7

1

12

High-throughput

0.479

High

333945

SMC2
Structural maintenance of chromosomes protein 2

1

12

High-throughput

0.479

High

426207

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

9

High-throughput

0.479

High

483518

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

6

High-throughput

0.479

High

698407

CALX
Calnexin

1

19

High-throughput

0.479

High

711849

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.479

High

711852

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

6

High-throughput

0.479

High

711857

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

711870

DSC2
Desmocollin-2

1

20

High-throughput

0.479

High

711874

FMR1
Fragile X messenger ribonucleoprotein 1

1

3

High-throughput

0.479

High

711877

GOGA3
Golgin subfamily A member 3

1

20

High-throughput

0.479

High

711890

FLOT2
Flotillin-2

1

14

High-throughput

0.479

High

711891

GOGB1
Golgin subfamily B member 1

1

16

High-throughput

0.479

High

711892

SYK
Lysine--tRNA ligase

1

7

High-throughput

0.479

High

711894

KIF14
Kinesin-like protein KIF14

1

15

High-throughput

0.479

High

711901

MIC60
MICOS complex subunit MIC60

1

2

High-throughput

0.479

High

711902

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

10

High-throughput

0.479

High

711903

GRDN
Girdin

1

20

High-throughput

0.479

High

711905

F1711
Protein FAM171A1

1

20

High-throughput

0.479

High

711911

LSR
Lipolysis-stimulated lipoprotein receptor

1

6

High-throughput

0.479

High

711916

NBEA
Neurobeachin

1

20

High-throughput

0.479

High

711917

DDX54
ATP-dependent RNA helicase DDX54

1

15

High-throughput

0.479

High

711918

DLG5
Disks large homolog 5

1

20

High-throughput

0.479

High

711919

FRS2
Fibroblast growth factor receptor substrate 2

1

20

High-throughput

0.479

High

711920

PDC6I
Programmed cell death 6-interacting protein

1

13

High-throughput

0.479

High

711924

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

11

High-throughput

0.479

High

711933

PKP2
Plakophilin-2

1

20

High-throughput

0.479

High

711940

GCP60
Golgi resident protein GCP60

1

15

High-throughput

0.479

High

711942

GORS2
Golgi reassembly-stacking protein 2

1

15

High-throughput

0.479

High

711945

WDR6
tRNA

1

20

High-throughput

0.479

High

711951

DJB11
DnaJ homolog subfamily B member 11

1

20

High-throughput

0.479

High

711953

ERRFI
ERBB receptor feedback inhibitor 1

1

16

Small-scale

0.479

High

711955

MYO6
Unconventional myosin-VI

1

12

High-throughput

0.479

High

711958

BAIP2
BAR/IMD domain-containing adapter protein 2

1

20

High-throughput

0.479

High

711960

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.479

High

477923

SNRPA
U1 small nuclear ribonucleoprotein A

1

6

High-throughput

0.457

High

711855

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

1

High-throughput

0.457

High

711856

BIEA
Biliverdin reductase A

1

2

High-throughput

0.457

High

711866

RACK1
Small ribosomal subunit protein RACK1

1

10

High-throughput

0.457

High

711913

PHF6
PHD finger protein 6

1

7

High-throughput

0.457

High

711936

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

13

High-throughput

0.457

High

711954

RALY
RNA-binding protein Raly

1

5

High-throughput

0.457

High

130383

SPT5H
Transcription elongation factor SPT5

1

19

High-throughput

0.437

High

283800

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

1

High-throughput

0.437

High

554781

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

8

High-throughput

0.437

High

566565

PDIA4
Protein disulfide-isomerase A4

1

20

High-throughput

0.437

High

569037

COBA2

1

3

High-throughput

0.437

High

642089

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

1

2

High-throughput

0.437

High

674084

BRD2
Bromodomain-containing protein 2

1

6

High-throughput

0.437

High

711867

RT05
Small ribosomal subunit protein uS5m

1

7

High-throughput

0.437

High

711868

RT06
Small ribosomal subunit protein bS6m

1

1

High-throughput

0.437

High

711869

RT09
Small ribosomal subunit protein uS9m

1

5

High-throughput

0.437

High

711880

GRSF1
G-rich sequence factor 1

1

20

High-throughput

0.437

High

711882

RM28
Large ribosomal subunit protein bL28m

1

3

High-throughput

0.437

High

711886

PWP1
Periodic tryptophan protein 1 homolog

1

14

High-throughput

0.437

High

711896

RABE1
Rab GTPase-binding effector protein 1

1

10

High-throughput

0.437

High

711898

TRIPB
Thyroid receptor-interacting protein 11

1

20

High-throughput

0.437

High

711910

PABP2
Polyadenylate-binding protein 2

1

8

High-throughput

0.437

High

711912

NUDC3
NudC domain-containing protein 3

1

8

High-throughput

0.437

High

711914

RM43
Large ribosomal subunit protein mL43

1

1

High-throughput

0.437

High

711922

RT31
Small ribosomal subunit protein mS31

1

4

High-throughput

0.437

High

711925

SYAP1
Synapse-associated protein 1

1

7

High-throughput

0.437

High

711926

P5CR2
Pyrroline-5-carboxylate reductase 2

1

4

High-throughput

0.437

High

711932

CDCA3
Cell division cycle-associated protein 3

1

12

High-throughput

0.437

High

711937

RM37
Large ribosomal subunit protein mL37

1

2

High-throughput

0.437

High

711938

NAA50
N-alpha-acetyltransferase 50

1

1

High-throughput

0.437

High

711941

UN45A
Protein unc-45 homolog A

1

18

High-throughput

0.437

High

711948

TECR
Very-long-chain enoyl-CoA reductase

1

6

High-throughput

0.437

High

711949

GGA3
ADP-ribosylation factor-binding protein GGA3

1

20

High-throughput

0.437

High

711950

RAI14
Ankycorbin

1

20

High-throughput

0.437

High

711952

TRM7
tRNA

1

8

High-throughput

0.437

High

711957

ANR26
Ankyrin repeat domain-containing protein 26

1

19

High-throughput

0.437

High

711959

SBDS
Ribosome maturation protein SBDS

1

1

High-throughput

0.437

High

711850

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.261

Low

711893

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.261

Low

134569

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.249

Low

711934

RM04
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.249

Low

711946

RT30
Large ribosomal subunit protein mL65

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025