HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: MINK1 (Q8N4C8)
Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)
Gene: MINK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 1332
+	Hs
		433891 LYN_HUMAN (1-509): 0: 582: 62.72		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		324717 LCK_HUMAN (1-509): 0: 661: 100.00		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		434067 LYN_HUMAN (1-509): 0: 582: 62.72		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		324719 LYN_HUMAN (1-509): 0: 582: 62.72		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		411778 LCK_HUMAN (1-509): 0: 661: 100.00		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		433850 LYN_HUMAN (1-509): 0: 582: 62.72		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		433949 LYN_HUMAN (1-509): 0: 582: 62.72		MARK4_HUMAN (16-739): 9.59e-118: 387: 17.15
+	Hs
		412163 FYN_HUMAN (30-507): 0: 586: 59.01		STK4_HUMAN (5-469): 5.1e-119: 381: 32.99
+	Hs
		337455 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		STK4_HUMAN (5-469): 5.1e-119: 381: 32.99
+	Hs
		789058 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		M3K10_HUMAN (21-845): 1.48e-113: 381: 19.26
+	Hs
		442897 HCK_HUMAN (1-509): 0: 602: 65.04		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60
+	Hs
		412425 FYN_HUMAN (30-507): 0: 586: 59.01		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60
+	Hs
		434099 LYN_HUMAN (1-509): 0: 582: 62.72		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60