Protein: PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein)

Gene: PNPT1
Organism: Homo sapiens
Interactions: 131
UniProt ID: Q8TCS8

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000957 - mitochondrial RNA catabolic process
GO:0000958 - mitochondrial mRNA catabolic process
GO:0000962 - positive regulation of mitochondrial RNA catabolic process
GO:0000964 - mitochondrial RNA 5'-end processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1349919

AURKB
Aurora kinase B

1

1

High-throughput

0.691

High

1242601

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

4

1

High-throughput

0.691

High

1349914

FAKD4
FAST kinase domain-containing protein 4

4

3

High-throughput

0.691

High

777623

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

3

1

High-throughput

0.650

High

1349944

ACAD9
Complex I assembly factor ACAD9, mitochondrial

3

0

High-throughput

0.638

High

1310258

HSC20
Iron-sulfur cluster co-chaperone protein HscB

3

0

Small-scale

0.625

High

1349929

TR61B
tRNA

3

0

High-throughput

0.622

High

401186

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.618

High

1087462

GRSF1
G-rich sequence factor 1

3

0

Small-scale

0.613

High

1349940

MTG2
Mitochondrial ribosome-associated GTPase 2

2

3

High-throughput

0.611

High

1008811

RED1
Double-stranded RNA-specific editase 1

2

8

High-throughput

0.606

High

716703

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

2

0

High-throughput

0.602

High

914681

RM12
Large ribosomal subunit protein bL12m

2

0

High-throughput

0.602

High

1146588

TMED2
Transmembrane emp24 domain-containing protein 2

2

0

High-throughput

0.602

High

1314773

SUV3
ATP-dependent RNA helicase SUPV3L1, mitochondrial

2

0

High-throughput

0.602

High

1123358

ICT1
Large ribosomal subunit protein mL62

2

0

High-throughput

0.585

High

869199

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

2

0

High-throughput

0.576

High

1135909

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

2

3

Small-scale

0.571

High

1349947

DDX28
Probable ATP-dependent RNA helicase DDX28

2

3

High-throughput

0.571

High

279842

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

1162437

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

1349930

HINT2
Adenosine 5'-monophosphoramidase HINT2

2

0

High-throughput

0.547

High

354741

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.546

High

188508

NVL
Nuclear valosin-containing protein-like

1

2

High-throughput

0.536

High

721041

CLIP1
CAP-Gly domain-containing linker protein 1

1

2

High-throughput

0.536

High

1009263

PRR3
Proline-rich protein 3

1

1

High-throughput

0.536

High

1334681

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.536

High

1349954

MRM2
rRNA methyltransferase 2, mitochondrial

1

1

High-throughput

0.536

High

415742

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

317898

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.513

High

940457

TCL1A
T-cell leukemia/lymphoma protein 1A

1

0

High-throughput

0.513

High

1158247

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.513

High

1235921

PDE12
2',5'-phosphodiesterase 12

1

0

High-throughput

0.513

High

1349918

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1349920

CALR3
Calreticulin-3

1

0

High-throughput

0.513

High

1349926

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.513

High

1349935

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.513

High

1349945

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

1349951

DIC
Mitochondrial dicarboxylate carrier

1

0

High-throughput

0.513

High

1349957

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.513

High

1349958

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1349963

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

1055072

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

2

High-throughput

0.500

High

1349923

GBP4
Guanylate-binding protein 4

1

0

High-throughput

0.493

High

1349922

ZSC31
Zinc finger and SCAN domain-containing protein 31

1

1

High-throughput

0.489

High

1349955

LRFN2
Leucine-rich repeat and fibronectin type-III domain-containing protein 2

1

3

High-throughput

0.489

High

1349962

WIF1
Wnt inhibitory factor 1

1

3

High-throughput

0.489

High

287062

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

9

High-throughput

0.481

High

61562

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.479

High

242364

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

282016

MPPB
Mitochondrial-processing peptidase subunit beta

1

5

High-throughput

0.479

High

287338

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

350933

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

3

High-throughput

0.479

High

412300

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

471149

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

532799

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

786184

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.479

High

856318

IF2M
Translation initiation factor IF-2, mitochondrial

1

12

High-throughput

0.479

High

882792

EFTU
Elongation factor Tu, mitochondrial

1

4

High-throughput

0.479

High

904953

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

1058161

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1067528

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

1083680

MPPA
Mitochondrial-processing peptidase subunit alpha

1

5

High-throughput

0.479

High

1090472

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.479

High

1138422

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1207081

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

1254762

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

1272942

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

3

High-throughput

0.479

High

1291082

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

Small-scale

0.479

High

1349912

NUDC2
NudC domain-containing protein 2

1

5

High-throughput

0.479

High

1349913

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

6

High-throughput

0.479

High

1349915

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

1349924

EFGM
Elongation factor G, mitochondrial

1

6

High-throughput

0.479

High

1349928

MTG1
Mitochondrial ribosome-associated GTPase 1

1

1

High-throughput

0.479

High

1349934

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

1349939

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

1349941

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

1349943

MET17
Ribosome assembly protein METTL17, mitochondrial

1

4

High-throughput

0.479

High

1349946

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

2

High-throughput

0.479

High

1349948

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

14

High-throughput

0.479

High

1349949

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

3

High-throughput

0.479

High

1349952

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

1349953

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1349961

TRAF6
TNF receptor-associated factor 6

1

3

High-throughput

0.479

High

66246

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

183689

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

519169

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

659538

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

828862

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

841841

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

851965

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

883289

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

927442

ATX1
Ataxin-1

1

0

High-throughput

0.458

High

1015621

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.458

High

1024111

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

1048605

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1117788

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1142606

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1229579

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1234463

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1314023

YAF2
YY1-associated factor 2

1

0

High-throughput

0.458

High

1349916

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1349917

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1349925

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

1349927

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1349932

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1349936

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1349937

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

High-throughput

0.458

High

1349938

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

1349942

EXO5
Exonuclease V

1

0

Small-scale

0.458

High

1349950

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1349959

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

142375

PEX7
Peroxisomal targeting signal 2 receptor

1

12

High-throughput

0.445

High

942770

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

High-throughput

0.445

High

1034500

TAGL
Transgelin

1

2

High-throughput

0.445

High

1315693

DND1
Dead end protein homolog 1

1

1

High-throughput

0.445

High

1349921

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

2

High-throughput

0.445

High

406419

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.437

High

1104025

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

330249

VENTX
Homeobox protein VENTX

1

2

High-throughput

0.407

High

1349933

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

1309601

SPA12
Serpin A12

3

0

High-throughput

0.345

High

1278617

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

1313087

T183A
Transmembrane protein 183A

1

0

High-throughput

0.279

Low

1324776

CIART
Circadian-associated transcriptional repressor

1

0

High-throughput

0.279

Low

1349956

PCDA4
Protocadherin alpha-4

1

0

High-throughput

0.279

Low

62775

XIRP2
Xin actin-binding repeat-containing protein 2

1

0

High-throughput

0.269

Low

106330

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1349960

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

1328102

TTC9C
Tetratricopeptide repeat protein 9C

1

0

High-throughput

0.232

Low

1349931

PCGF6
Polycomb group RING finger protein 6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025