Protein: EXOS4
Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A)

Gene: EXOS4, EXOSC4
Organism: Homo sapiens
Interactions: 170
UniProt ID: Q9NPD3

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000460 - maturation of 5.8S rRNA

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1054512

EXOS9
Exosome complex component RRP45

11

19

Small-scale

0.980

High

1446191

EXOS3
Exosome complex component RRP40

10

12

Small-scale

0.978

High

1137671

EXOS7
Exosome complex component RRP42

10

19

Small-scale

0.977

High

1118340

EXOS2
Exosome complex component RRP4

10

20

Small-scale

0.976

High

1446210

EXOS1
Exosome complex component CSL4

8

20

Small-scale

0.973

High

1384031

EXOS8
Exosome complex component RRP43

6

19

Small-scale

0.953

High

1353559

DI3L1
DIS3-like exonuclease 1

5

19

Small-scale

0.932

High

1209122

EXOS6
Exosome complex component MTR3

4

19

Small-scale

0.909

High

1446190

EXOS5
Exosome complex component RRP46

4

19

Small-scale

0.909

High

1446209

RRP44
Exosome complex exonuclease RRP44

2

19

Small-scale

0.789

High

1032251

EXOSX
Exosome complex component 10

8

11

Small-scale

0.752

High

1405167

MPH6
M-phase phosphoprotein 6

6

7

Small-scale

0.729

High

1446211

HBS1L
HBS1-like protein

4

5

Small-scale

0.686

High

838792

MTREX
Exosome RNA helicase MTR4

3

17

Small-scale

0.667

High

1119078

C1D
Nuclear nucleic acid-binding protein C1D

3

4

High-throughput

0.662

High

1240264

ZCHC8
Zinc finger CCHC domain-containing protein 8

3

4

High-throughput

0.650

High

1446193

SAS10
Something about silencing protein 10

2

2

High-throughput

0.628

High

397004

ESR1
Estrogen receptor

3

12

High-throughput

0.624

High

1446189

EXOS4
Exosome complex component RRP41

1

19

Small-scale

0.621

High

1290747

ZCH18
Zinc finger CCCH domain-containing protein 18

2

5

High-throughput

0.611

High

1446212

RBM7
RNA-binding protein 7

2

10

High-throughput

0.611

High

1348525

LNX1
E3 ubiquitin-protein ligase LNX

2

1

High-throughput

0.606

High

244772

ZC3H1
Zinc finger C3H1 domain-containing protein

2

6

High-throughput

0.601

High

1161688

IF16
Gamma-interferon-inducible protein 16

2

6

High-throughput

0.584

High

140448

SDCB1
Syntenin-1

2

0

High-throughput

0.580

High

940504

DPOE2
DNA polymerase epsilon subunit 2

2

0

High-throughput

0.580

High

1429662

COMD4
COMM domain-containing protein 4

2

1

High-throughput

0.571

High

485437

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.536

High

905172

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.536

High

937350

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

9

High-throughput

0.536

High

970120

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

1027776

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.536

High

1085714

TBL3
Transducin beta-like protein 3

1

13

High-throughput

0.536

High

1130856

RRP5
Protein RRP5 homolog

1

6

High-throughput

0.536

High

1144740

PWP2
Periodic tryptophan protein 2 homolog

1

18

High-throughput

0.536

High

1251446

GGYF2
GRB10-interacting GYF protein 2

1

5

High-throughput

0.536

High

1288260

LYRIC
Protein LYRIC

1

1

High-throughput

0.536

High

1336633

PAPD5
Terminal nucleotidyltransferase 4B

1

3

High-throughput

0.536

High

1341147

WDR36
WD repeat-containing protein 36

1

14

High-throughput

0.536

High

1356509

PHF10
PHD finger protein 10

1

5

High-throughput

0.536

High

1360489

PSPC1
Paraspeckle component 1

1

5

High-throughput

0.536

High

1367349

ESR2
Estrogen receptor beta

1

12

High-throughput

0.536

High

1381594

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

11

High-throughput

0.536

High

1395215

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

2

High-throughput

0.536

High

1399757

RBM14
RNA-binding protein 14

1

1

High-throughput

0.536

High

1414866

WDR18
WD repeat-containing protein 18

1

10

High-throughput

0.536

High

1415598

AFG2B
ATPase family gene 2 protein homolog B

1

1

High-throughput

0.536

High

1429079

AICDA
Single-stranded DNA cytosine deaminase

1

6

Small-scale

0.536

High

1435070

NOL6
Nucleolar protein 6

1

2

High-throughput

0.536

High

1438645

CBX8
Chromobox protein homolog 8

1

3

High-throughput

0.536

High

1446196

SLTM
SAFB-like transcription modulator

1

1

High-throughput

0.536

High

1446207

WDR3
WD repeat-containing protein 3

1

20

High-throughput

0.536

High

1446208

DRG1
Developmentally-regulated GTP-binding protein 1

1

2

High-throughput

0.536

High

1446213

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

1

15

High-throughput

0.536

High

207980

TET3
Methylcytosine dioxygenase TET3

1

2

High-throughput

0.515

High

627713

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.513

High

686454

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.513

High

860962

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.513

High

884240

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

892629

DNLI3
DNA ligase 3

1

0

High-throughput

0.513

High

961851

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.513

High

973093

RS29
Small ribosomal subunit protein uS14

1

0

High-throughput

0.513

High

977379

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.513

High

1037656

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.513

High

1130469

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.513

High

1168580

KNOP1
Lysine-rich nucleolar protein 1

1

0

High-throughput

0.513

High

1244534

SHQ1
Protein SHQ1 homolog

1

0

High-throughput

0.513

High

1294427

SPAS2
Spermatogenesis-associated serine-rich protein 2

1

0

High-throughput

0.513

High

1383097

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.513

High

1446195

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

1446199

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

0

High-throughput

0.513

High

1446204

EI2BD
Translation initiation factor eIF2B subunit delta

1

0

High-throughput

0.513

High

1446215

NS1BP
Influenza virus NS1A-binding protein

1

0

High-throughput

0.513

High

305850

DXO
Decapping and exoribonuclease protein

1

1

High-throughput

0.508

High

572728

AK1A1
Aldo-keto reductase family 1 member A1

1

1

High-throughput

0.508

High

996350

EF1A1
Elongation factor 1-alpha 1

1

5

High-throughput

0.508

High

1120353

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

2

High-throughput

0.508

High

1149469

SKI2
Superkiller complex protein 2

1

18

High-throughput

0.508

High

1242637

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

1

High-throughput

0.508

High

1400371

NEK1
Serine/threonine-protein kinase Nek1

1

1

High-throughput

0.508

High

951862

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

High-throughput

0.501

High

1271352

LRC8D
Volume-regulated anion channel subunit LRRC8D

1

0

High-throughput

0.486

High

1347092

G45IP
Large ribosomal subunit protein mL64

1

0

High-throughput

0.486

High

1358910

SEN15
tRNA-splicing endonuclease subunit Sen15

1

0

High-throughput

0.486

High

1446203

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

0

High-throughput

0.486

High

1060636

PPARA
Peroxisome proliferator-activated receptor alpha

1

12

High-throughput

0.481

High

1206553

PRC2B
Protein PRRC2B

1

2

High-throughput

0.481

High

129451

MEN1
Menin

1

4

High-throughput

0.479

High

132314

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.479

High

194359

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

210352

PHF1
PHD finger protein 1

1

1

High-throughput

0.479

High

252170

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

4

High-throughput

0.479

High

272477

OBSL1
Obscurin-like protein 1

1

3

High-throughput

0.479

High

285485

EED
Polycomb protein EED

1

7

High-throughput

0.479

High

316041

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

317589

SLIT2
Slit homolog 2 protein

1

1

High-throughput

0.479

High

320072

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

346369

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

9

High-throughput

0.479

High

350144

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

473106

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

9

High-throughput

0.479

High

537952

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

620603

NUCL
Nucleolin

1

1

High-throughput

0.479

High

658422

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

831477

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

867438

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.479

High

881811

DHYS
Deoxyhypusine synthase

1

1

High-throughput

0.479

High

897401

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.479

High

897985

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.479

High

914967

THOP1
Thimet oligopeptidase

1

4

High-throughput

0.479

High

937927

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.479

High

971127

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

980375

H4
Histone H4

1

1

High-throughput

0.479

High

1092249

NFX1
Transcriptional repressor NF-X1

1

3

High-throughput

0.479

High

1138662

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

1155799

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

1227507

A16L1
Autophagy-related protein 16-1

1

11

High-throughput

0.479

High

1235535

IFIX
Pyrin and HIN domain-containing protein 1

1

6

High-throughput

0.479

High

1255656

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1292413

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

1

Small-scale

0.479

High

1323621

LRC47
Leucine-rich repeat-containing protein 47

1

1

High-throughput

0.479

High

1352766

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

1368631

KAT6A
Histone acetyltransferase KAT6A

1

5

High-throughput

0.479

High

1380179

FBXW7
F-box/WD repeat-containing protein 7

1

5

High-throughput

0.479

High

1393721

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

1394559

RSRC1
Serine/Arginine-related protein 53

1

1

High-throughput

0.479

High

1407892

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

1433965

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

1437717

RENT2
Regulator of nonsense transcripts 2

1

2

Small-scale

0.479

High

1438027

RC3H2
Roquin-2

1

2

High-throughput

0.479

High

1438978

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

4

High-throughput

0.479

High

1446192

ANLN
Anillin

1

3

High-throughput

0.479

High

1446194

DCA13
DDB1- and CUL4-associated factor 13

1

13

Small-scale

0.479

High

1446197

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

1446200

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

5

High-throughput

0.479

High

1446202

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1446206

FZR1
Fizzy-related protein homolog

1

13

High-throughput

0.479

High

1136499

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.460

High

157883

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

294370

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

607656

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

0

High-throughput

0.458

High

861300

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

959261

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

1124060

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.458

High

1156867

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1178396

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1370121

RENT1
Regulator of nonsense transcripts 1

1

0

Small-scale

0.458

High

1397456

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1431126

REN3A
Regulator of nonsense transcripts 3A

1

0

Small-scale

0.458

High

1446214

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.458

High

97179

E9PQZ5
PHD finger protein 1

1

1

High-throughput

0.445

High

1208812

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

2

High-throughput

0.445

High

412653

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

908621

LUM
Lumican

1

1

High-throughput

0.437

High

1327214

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

1446205

HECD1
E3 ubiquitin-protein ligase HECTD1

1

7

High-throughput

0.437

High

328166

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

0

High-throughput

0.426

High

547207

PYC
Pyruvate carboxylase, mitochondrial

1

0

High-throughput

0.426

High

1209689

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1435945

NRDE2
Nuclear exosome regulator NRDE2

1

0

High-throughput

0.426

High

96995

E9PJN9
Ribosomal protein S3

1

1

High-throughput

0.407

High

116290

H3BNT4
M-phase phosphoprotein 6

1

7

High-throughput

0.407

High

568509

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

1391617

RM48
Large ribosomal subunit protein mL48

1

0

High-throughput

0.279

Low

1446201

TXD16
Thioredoxin domain-containing protein 16

1

0

High-throughput

0.279

Low

1446198

NSMA3
Sphingomyelin phosphodiesterase 4

1

0

High-throughput

0.265

Low

333524

MPZL1
Myelin protein zero-like protein 1

1

0

High-throughput

0.251

Low

380155

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.249

Low

1126182

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1417446

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025