HitPredict

Interactor 1: LCK (P06240)
Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: HCLS1 (P49710)
Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1)
Gene: HCLS1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	7628441, 10713104
Identification Methods	anti bait coimmunoprecipitation, filter binding
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0042531 - positive regulation of tyrosine phosphorylation of STAT protein GO:0044877 - protein-containing complex binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Mm			1 486
+	Mm
		763381 FYN_MOUSE (1-507): 0: 590: 53.85		HCLS1_MOUSE (1-486): 1.65e-134: 399: 100.00
+	Mm
		639438 LYN_MOUSE (1-509): 0: 567: 62.72		HCLS1_MOUSE (1-486): 1.65e-134: 399: 100.00
+	Hs
		454795 FGR_HUMAN (1-507): 0: 579: 52.57		HCLS1_HUMAN (1-486): 1.25e-126: 379: 79.76
+	Hs
		433350 YES_HUMAN (1-507): 0: 576: 53.60		SRC8_HUMAN (1-485): 3.51e-126: 380: 41.97
+	Hs
		522981 SRC_HUMAN (2-507): 0: 576: 54.13		SRC8_HUMAN (1-485): 3.51e-126: 380: 41.97
+	Mm
		639446 LYN_MOUSE (1-509): 0: 567: 62.72		SRC8_MOUSE (1-485): 3.65e-128: 385: 42.65
+	Hs
		433551 LYN_HUMAN (1-509): 0: 566: 63.37		HCLS1_HUMAN (1-486): 1.25e-126: 379: 79.76
+	Hs
		412328 FYN_HUMAN (1-507): 0: 591: 54.03		SH3G2_HUMAN (143-486): 8.47e-37: 140: 15.51
+	Hs
		412329 FYN_HUMAN (1-507): 0: 591: 54.03		SH3G3_HUMAN (143-486): 7.4e-37: 140: 13.02
+	Hs
		412404 FYN_HUMAN (1-507): 0: 591: 54.03		ASAP1_HUMAN (206-486): 1.58e-33: 137: 14.83
+	Hs
		442894 HCK_HUMAN (1-509): 0: 591: 65.63		ASAP1_HUMAN (206-486): 1.58e-33: 137: 14.83
+	Hs
		523197 SRC_HUMAN (2-507): 0: 576: 54.13		ASAP1_HUMAN (206-486): 1.58e-33: 137: 14.83
+	Mm
		639449 LYN_MOUSE (1-509): 0: 567: 62.72		DBNL_MOUSE (187-486): 8.88e-38: 145: 27.47
+	Hs
		207757 ABL1_HUMAN (34-506): 1.69e-167: 505: 40.54		PPIP1_HUMAN (94-486): 3e-38: 145: 13.28
+	Hs
		337550 ABL1_HUMAN (34-506): 1.69e-167: 505: 40.54		PACN1_HUMAN (139-486): 8.46e-37: 142: 18.25
+	Hs
		337590 ABL1_HUMAN (34-506): 1.69e-167: 505: 40.54		ASAP1_HUMAN (206-486): 1.58e-33: 137: 14.83
+	Hs
		433781 LYN_HUMAN (1-509): 0: 566: 63.37		ITSN1_HUMAN (30-486): 4.13e-12: 70.9: 14.91
+	Hs
		235462 ABL1_HUMAN (34-506): 1.69e-167: 505: 40.54		VINEX_HUMAN (323-486): 1.36e-13: 75.1: 18.68
+	Hs
		298944 ABL1_HUMAN (34-506): 1.69e-167: 505: 40.54		SRBS2_HUMAN (393-486): 2e-12: 71.9: 28.13
+	Hs
		337572 ABL1_HUMAN (34-506): 1.69e-167: 505: 40.54		ABI2_HUMAN (275-486): 3.5e-12: 70.3: 18.72