Protein: EI2BD
Translation initiation factor eIF2B subunit delta (eIF2B GDP-GTP exchange factor subunit delta)

Gene: EI2BD, EIF2B4
Organism: Homo sapiens
Interactions: 147
UniProt ID: Q9UI10

Gene Ontology (top 5):
GO:0001541 - ovarian follicle development
GO:0002183 - cytoplasmic translational initiation
GO:0003743 - translation initiation factor activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

890170

EI2BB
Translation initiation factor eIF2B subunit beta

8

15

High-throughput

0.971

High

1124240

EI2BA
Translation initiation factor eIF2B subunit alpha

3

14

High-throughput

0.861

High

1431369

OPN3
Opsin-3

3

3

High-throughput

0.667

High

1459038

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

3

2

High-throughput

0.667

High

1200608

Q53XC2
Translation initiation factor eIF2B subunit beta

1

15

High-throughput

0.665

High

639178

SYT1
Synaptotagmin-1

3

5

High-throughput

0.662

High

1095955

EI2BE
Translation initiation factor eIF2B subunit epsilon

3

16

Small-scale

0.660

High

1447976

EI2BG
Translation initiation factor eIF2B subunit gamma

1

12

High-throughput

0.618

High

733518

GP183
G-protein coupled receptor 183

3

7

High-throughput

0.609

High

845491

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

10

High-throughput

0.609

High

1294860

STX12
Syntaxin-12

3

2

High-throughput

0.609

High

1399300

NECT4
Nectin-4

3

5

High-throughput

0.609

High

1405352

P2RX4
P2X purinoceptor 4

3

2

High-throughput

0.609

High

1460169

CAH14
Carbonic anhydrase 14

3

2

High-throughput

0.609

High

1330757

SIGL1
SIGLEC family-like protein 1

3

2

High-throughput

0.604

High

1436012

PACC1
Proton-activated chloride channel

3

2

High-throughput

0.604

High

1460168

FZD10
Frizzled-10

2

0

High-throughput

0.602

High

831603

CCNF
Cyclin-F

2

3

High-throughput

0.601

High

1022984

EFNB1
Ephrin-B1

2

5

High-throughput

0.601

High

363987

EGFR
Epidermal growth factor receptor

2

4

Small-scale

0.584

High

1380235

FBXW7
F-box/WD repeat-containing protein 7

2

1

Small-scale

0.584

High

438107

GLPB
Glycophorin-B

2

4

High-throughput

0.574

High

640321

EPHA1
Ephrin type-A receptor 1

2

4

High-throughput

0.574

High

592749

LEUK
Leukosialin

2

2

High-throughput

0.558

High

914500

EFNB2
Ephrin-B2

2

5

High-throughput

0.558

High

1326238

PNKD
Probable thioesterase PNKD

2

1

High-throughput

0.558

High

1153455

CD226
CD226 antigen

2

6

High-throughput

0.549

High

1331874

SYT2
Synaptotagmin-2

2

5

High-throughput

0.549

High

141159

NOP56
Nucleolar protein 56

1

2

High-throughput

0.536

High

220034

XRCC3
DNA repair protein XRCC3

1

2

High-throughput

0.536

High

281689

MTX2
Metaxin-2

1

1

High-throughput

0.536

High

486635

TACD2
Tumor-associated calcium signal transducer 2

1

2

High-throughput

0.536

High

564521

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

625693

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.536

High

694053

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.536

High

832144

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

6

High-throughput

0.536

High

845999

DCC
Netrin receptor DCC

1

2

Small-scale

0.536

High

933365

IF5
Eukaryotic translation initiation factor 5

1

5

High-throughput

0.536

High

1027831

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.536

High

1249867

BTNL9
Butyrophilin-like protein 9

1

3

High-throughput

0.536

High

1370606

FGF14
Fibroblast growth factor 14

1

1

High-throughput

0.536

High

1437180

CHODL
Chondrolectin

1

2

High-throughput

0.536

High

1460171

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

2

High-throughput

0.536

High

1460172

E41L3
Band 4.1-like protein 3

1

1

High-throughput

0.536

High

370803

FOS
Protein c-Fos

1

3

High-throughput

0.515

High

407141

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.513

High

431271

LA
Lupus La protein

1

0

High-throughput

0.513

High

447550

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

1446204

EXOS4
Exosome complex component RRP41

1

0

High-throughput

0.513

High

1460174

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

449542

LIPL
Lipoprotein lipase

1

0

High-throughput

0.493

High

822902

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.493

High

988007

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.493

High

159112

ENPP3
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

1

1

High-throughput

0.489

High

182819

GP182
G-protein coupled receptor 182

1

8

High-throughput

0.489

High

253914

TPST2
Protein-tyrosine sulfotransferase 2

1

2

High-throughput

0.489

High

669291

PTAFR
Platelet-activating factor receptor

1

9

High-throughput

0.489

High

683362

TNR5
Tumor necrosis factor receptor superfamily member 5

1

2

High-throughput

0.489

High

688643

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

4

High-throughput

0.489

High

749296

CD70
CD70 antigen

1

1

High-throughput

0.489

High

762419

BTC
Probetacellulin [Cleaved into: Betacellulin

1

2

High-throughput

0.489

High

1101695

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

10

High-throughput

0.489

High

1142210

P2RY6
P2Y purinoceptor 6

1

8

High-throughput

0.489

High

1291705

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

2

High-throughput

0.489

High

1326578

PP4P2
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

3

High-throughput

0.489

High

1349143

F174A
Membrane protein FAM174A

1

1

High-throughput

0.489

High

1363161

CLC2B
C-type lectin domain family 2 member B

1

4

High-throughput

0.489

High

1404270

SEC62
Translocation protein SEC62

1

2

High-throughput

0.489

High

1428610

DNAI2
Dynein axonemal intermediate chain 2

1

3

High-throughput

0.489

High

1431000

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.489

High

1438681

PCDH9
Protocadherin-9

1

1

High-throughput

0.489

High

1460165

CC018
Uncharacterized protein C3orf18

1

2

High-throughput

0.489

High

1460170

CLC4A
C-type lectin domain family 4 member A

1

1

High-throughput

0.489

High

1460173

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

1

High-throughput

0.489

High

173516

XPO1
Exportin-1

1

7

High-throughput

0.479

High

243227

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

262331

SCN2B
Sodium channel regulatory subunit beta-2

1

3

High-throughput

0.479

High

401668

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

714499

PML
Protein PML

1

3

High-throughput

0.479

High

783446

TRI23
E3 ubiquitin-protein ligase TRIM23

1

1

High-throughput

0.479

High

912619

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

High-throughput

0.479

High

984324

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.479

High

1024915

VIGLN
Vigilin

1

1

High-throughput

0.479

High

1125253

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

1

High-throughput

0.479

High

1126662

GRB7
Growth factor receptor-bound protein 7

1

1

Small-scale

0.479

High

1138731

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1227654

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.479

High

1229749

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1255991

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1359463

LMO7
LIM domain only protein 7

1

1

High-throughput

0.479

High

1368189

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

1383152

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

1393806

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

1395985

DNJC1
DnaJ homolog subfamily C member 1

1

1

High-throughput

0.479

High

1434168

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

1459214

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1460164

XPO7
Exportin-7

1

7

High-throughput

0.479

High

1460175

5MP1
eIF5-mimic protein 1

1

8

High-throughput

0.479

High

369559

ANGT
Angiotensinogen

1

1

High-throughput

0.470

High

872850

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

904407

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.458

High

1045882

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1364661

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1411748

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

1446484

DCP1A
mRNA-decapping enzyme 1A

1

0

High-throughput

0.458

High

1447405

ANLN
Anillin

1

0

High-throughput

0.458

High

1448923

DUS22
Dual specificity protein phosphatase 22

1

0

High-throughput

0.458

High

1453024

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1459525

TES
Testin

1

0

High-throughput

0.458

High

171608

S27A2
Long-chain fatty acid transport protein 2

1

1

High-throughput

0.445

High

532180

CD28
T-cell-specific surface glycoprotein CD28

1

2

High-throughput

0.445

High

1402921

CK5P2
CDK5 regulatory subunit-associated protein 2

1

4

High-throughput

0.445

High

1404481

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.445

High

1460166

AGO1
Protein argonaute-1

1

1

High-throughput

0.445

High

1380512

UBE2F
NEDD8-conjugating enzyme UBE2F

1

0

High-throughput

0.438

High

412767

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

965311

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.437

High

1100503

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.437

High

1249306

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1276926

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1313872

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

1337247

MCU
Calcium uniporter protein, mitochondrial

1

2

High-throughput

0.437

High

1367526

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

1380603

IGSF8
Immunoglobulin superfamily member 8

1

2

High-throughput

0.437

High

1433712

EMRE
Essential MCU regulator, mitochondrial

1

2

High-throughput

0.437

High

1460167

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

166442

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.426

High

530534

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

880885

NRAM2
Natural resistance-associated macrophage protein 2

1

0

High-throughput

0.426

High

104244

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

430477

JUN
Transcription factor Jun

1

2

High-throughput

0.407

High

1288464

SO6A1
Solute carrier organic anion transporter family member 6A1

1

2

High-throughput

0.407

High

1446223

SO1B3
Solute carrier organic anion transporter family member 1B3

1

2

High-throughput

0.407

High

378882

CD4
T-cell surface glycoprotein CD4

2

0

High-throughput

0.328

High

141793

MFNG
Beta-1,3-N-acetylglucosaminyltransferase manic fringe

1

0

High-throughput

0.279

Low

154903

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

0

High-throughput

0.279

Low

932352

ARSF
Arylsulfatase F

1

0

High-throughput

0.279

Low

1395526

M4A4A
Membrane-spanning 4-domains subfamily A member 4A

1

0

High-throughput

0.279

Low

1431378

TSN10
Tetraspanin-10

1

0

High-throughput

0.279

Low

398012

KLKB1
Plasma kallikrein

1

0

High-throughput

0.268

Low

728839

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

High-throughput

0.268

Low

895335

GATM
Glycine amidinotransferase, mitochondrial

1

0

High-throughput

0.268

Low

373426

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

377773

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

473165

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.249

Low

879592

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

1449959

S39A9
Zinc transporter ZIP9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025