HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: P55G (Q92569)
Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)
Gene: PIK3R3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PI3K_P85_iSH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 537 Hs			1 461
+	Hs
		337307 FYN_HUMAN (1-537): 0: 643: 100.00		ABL1_HUMAN (3-461): 1.02e-93: 308: 16.12
+	Hs
		412033 FYN_HUMAN (1-537): 0: 643: 100.00		P85A_HUMAN (48-455): 9.1e-92: 295: 79.17
+	Mm
		643066 FYN_MOUSE (1-537): 0: 642: 99.44		P85A_MOUSE (60-455): 4.12e-90: 291: 80.81
+	Hs
		129164 FYN_HUMAN (1-537): 0: 643: 100.00		P85B_HUMAN (56-453): 2.19e-87: 283: 74.12
+	Hs
		412070 FYN_HUMAN (1-537): 0: 643: 100.00		ABL2_HUMAN (324-459): 5.26e-21: 98.5: 25.36
+	Hs
		411545 FYN_HUMAN (1-537): 0: 643: 100.00		LCK_HUMAN (309-458): 5.54e-21: 97.3: 25.95
+	Hs
		411936 FYN_HUMAN (1-537): 0: 643: 100.00		FYN_HUMAN (326-459): 6.82e-20: 94.2: 26.06
+	Hs
		412066 FYN_HUMAN (1-537): 0: 643: 100.00		CSK_HUMAN (357-456): 1.18e-19: 93: 34.65
+	Hs
		411946 FYN_HUMAN (1-537): 0: 643: 100.00		YES_HUMAN (317-459): 6.84e-19: 91.2: 23.72
+	Hs
		411969 FYN_HUMAN (1-537): 0: 643: 100.00		SRC_HUMAN (323-459): 8.26e-19: 90.8: 24.14
+	Hs
		412071 FYN_HUMAN (1-537): 0: 643: 100.00		FRK_HUMAN (256-459): 1.27e-18: 90: 24.04
+	Hs
		412098 FYN_HUMAN (1-537): 0: 643: 100.00		VAV2_HUMAN (38-159): 4.46e-13: 73.7: 22.95
+	Hs
		411981 FYN_HUMAN (1-537): 0: 643: 100.00		VAV_HUMAN (65-170): 4e-12: 70.6: 27.36
+	Hs
		181765 FYN_HUMAN (1-537): 0: 643: 100.00		SOCS1_HUMAN (46-169): 5.58e-13: 69.8: 23.20
+	Hs
		411992 FYN_HUMAN (1-537): 0: 643: 100.00		PLCG2_HUMAN (337-452): 6.98e-12: 69.8: 33.33
+	Rn
		1376717 SRC_RAT (1-537): 0: 601: 67.72		SRC_RAT (323-459): 5.91e-19: 91.2: 24.14
+	Rn
		693648 SRC_RAT (1-537): 0: 601: 67.72		CSK_RAT (286-457): 6.83e-19: 90.8: 24.86
+	Rn
		989767 SRC_RAT (1-537): 0: 601: 67.72		LYN_RAT (298-458): 7.79e-19: 90.8: 24.85
+	Mm
		403406 SRC_MOUSE (1-537): 0: 599: 68.33		SRC_MOUSE (323-459): 7.66e-19: 91.2: 24.14
+	Mm
		403440 SRC_MOUSE (1-537): 0: 599: 68.33		SHC3_MOUSE (32-162): 4.26e-13: 72.9: 29.77