HitPredict

Interactor 1: CHLE (P06276)
Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)
Gene: BCHE

Interactor 2: CHLE (P06276)
Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)
Gene: BCHE

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.927

The method score is based on:

Property Details
Experiments 10529218, 17660298, 21059932, 22726956, 20883446
Identification Methods two hybrid, comigration in non denaturing gel electrophoresis, molecular sieving, cosedimentation in solution, x-ray crystallography, chromatography technology
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains AChE_tetra~AChE_tetra, AChE_tetra~COesterase, COesterase~COesterase
Common GO terms GO:0001540 - amyloid-beta binding
GO:0003824 - catalytic activity
GO:0003990 - acetylcholinesterase activity
GO:0004104 - cholinesterase activity
GO:0005576 - extracellular region
and 20 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 602
Hs

1 602
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn
+ Hs
+ Mm
+ Ce
+ Hs
+ Dm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024