Protein: P53
Cellular tumor antigen p53 (Tumor suppressor p53)

Gene: P53, Tp53
Organism: Mus musculus
Interactions: 103
UniProt ID: P02340

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000423 - mitophagy
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

382448

MDM2
E3 ubiquitin-protein ligase Mdm2

34

10

Small-scale

0.994

High

74242

EP300
Histone acetyltransferase p300

6

18

Small-scale

0.937

High

382443

P53
Cellular tumor antigen p53

6

14

Small-scale

0.923

High

205232

MDM4
Protein Mdm4

5

10

Small-scale

0.919

High

382494

B2CL1
Bcl-2-like protein 1

3

9

Small-scale

0.847

High

107042

F8VPR5
histone acetyltransferase

2

17

Small-scale

0.757

High

313134

P63
Tumor protein 63

2

14

Small-scale

0.757

High

382516

P73
Tumor protein p73

2

14

Small-scale

0.757

High

267022

BARD1
BRCA1-associated RING domain protein 1

2

13

Small-scale

0.754

High

382485

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

5

Small-scale

0.683

High

382506

MK08
Mitogen-activated protein kinase 8

4

12

Small-scale

0.676

High

382466

TP53B
TP53-binding protein 1

1

11

Small-scale

0.646

High

382480

SKIL
Ski-like protein

2

2

Small-scale

0.624

High

382493

ARF
Tumor suppressor ARF

3

0

Small-scale

0.622

High

382525

IKBA
NF-kappa-B inhibitor alpha

1

10

High-throughput

0.621

High

97999

ANR11
Ankyrin repeat domain-containing protein 11

1

16

Small-scale

0.618

High

382445

BCL2
Apoptosis regulator Bcl-2

1

9

Small-scale

0.618

High

382454

CBP
Histone lysine acetyltransferase CREBBP

1

17

Small-scale

0.618

High

382472

BAX
Apoptosis regulator BAX

1

9

Small-scale

0.618

High

382499

DAPK1
Death-associated protein kinase 1

1

7

Small-scale

0.618

High

382508

REV1
DNA repair protein REV1

1

3

Small-scale

0.618

High

382527

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

9

Small-scale

0.618

High

205197

DAXX
Death domain-associated protein 6

2

4

Small-scale

0.611

High

147685

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

4

Small-scale

0.584

High

205247

AXIN1
Axin-1

2

1

Small-scale

0.584

High

382505

WWOX
WW domain-containing oxidoreductase

2

5

Small-scale

0.584

High

382520

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

3

Small-scale

0.584

High

382523

GSK3B
Glycogen synthase kinase-3 beta

2

6

Small-scale

0.584

High

382487

MELK
Maternal embryonic leucine zipper kinase

1

2

Small-scale

0.578

High

382449

PAX3
Paired box protein Pax-3

1

4

Small-scale

0.561

High

382488

DMC1
Meiotic recombination protein DMC1/LIM15 homolog

1

3

Small-scale

0.561

High

382507

BRNP1
BMP/retinoic acid-inducible neural-specific protein 1

1

1

Small-scale

0.561

High

382526

ZN292
Zinc finger protein 292

1

5

High-throughput

0.541

High

382474

KCMA1
Calcium-activated potassium channel subunit alpha-1

1

0

Small-scale

0.537

High

382463

HMGB1
High mobility group protein B1

1

9

Small-scale

0.536

High

382467

BACH1
Transcription regulator protein BACH1

1

11

Small-scale

0.536

High

382491

TIF1A
Transcription intermediary factor 1-alpha

1

20

Small-scale

0.536

High

108975

G3X9P9
SUMO/sentrin specific peptidase 2-like 2A

1

5

Small-scale

0.528

High

382451

TWST1
Twist-related protein 1

1

2

Small-scale

0.515

High

382455

MK14
Mitogen-activated protein kinase 14

1

13

Small-scale

0.515

High

382462

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

3

High-throughput

0.515

High

382469

CDK2
Cyclin-dependent kinase 2

1

6

Small-scale

0.501

High

382490

ATM
Serine-protein kinase ATM

1

7

Small-scale

0.501

High

382513

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

3

Small-scale

0.501

High

148635

HDAC1
Histone deacetylase 1

1

7

Small-scale

0.500

High

382482

NCOR1
Nuclear receptor corepressor 1

1

5

Small-scale

0.500

High

382486

MAFK
Transcription factor MafK

1

1

Small-scale

0.500

High

313148

PIAS1
E3 SUMO-protein ligase PIAS1

1

10

Small-scale

0.481

High

382470

SMYD1
Histone-lysine N-methyltransferase Smyd1

1

2

Small-scale

0.481

High

382479

SIN3A
Paired amphipathic helix protein Sin3a

1

2

High-throughput

0.481

High

382496

MED16
Mediator of RNA polymerase II transcription subunit 16

1

4

High-throughput

0.481

High

382501

PIAS2
E3 SUMO-protein ligase PIAS2

1

10

Small-scale

0.481

High

382517

PIAS4
E3 SUMO-protein ligase PIAS4

1

10

Small-scale

0.481

High

267029

1433S
14-3-3 protein sigma

1

7

Small-scale

0.479

High

313388

SP1
Transcription factor Sp1

1

8

Small-scale

0.479

High

382446

HS71L
Heat shock 70 kDa protein 1-like

1

6

Small-scale

0.479

High

382447

HS71B
Heat shock 70 kDa protein 1B

1

6

Small-scale

0.479

High

382450

NECD
Necdin

1

8

Small-scale

0.479

High

382452

IRS1
Insulin receptor substrate 1

1

9

Small-scale

0.479

High

382453

CDN1A
Cyclin-dependent kinase inhibitor 1

1

4

Small-scale

0.479

High

382456

CCNG1
Cyclin-G1

1

9

Small-scale

0.479

High

382458

RUVB1
RuvB-like 1

1

2

Small-scale

0.479

High

382459

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

5

Small-scale

0.479

High

382460

RS26
Small ribosomal subunit protein eS26

1

1

Small-scale

0.479

High

382461

YBOX1
Y-box-binding protein 1

1

2

Small-scale

0.479

High

382464

GFI1
Zinc finger protein Gfi-1

1

7

Small-scale

0.479

High

382465

ELAV1
ELAV-like protein 1

1

4

Small-scale

0.479

High

382468

PRKDC
DNA-dependent protein kinase catalytic subunit

1

8

Small-scale

0.479

High

382471

TF65
Transcription factor p65

1

8

Small-scale

0.479

High

382473

RAD51
DNA repair protein RAD51 homolog 1

1

3

Small-scale

0.479

High

382475

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

9

Small-scale

0.479

High

382476

DDB1
DNA damage-binding protein 1

1

3

Small-scale

0.479

High

382477

KMT2E
Inactive histone-lysine N-methyltransferase 2E

1

11

Small-scale

0.479

High

382478

HERC2
E3 ubiquitin-protein ligase HERC2

1

18

Small-scale

0.479

High

382481

KLF4
Krueppel-like factor 4

1

12

Small-scale

0.479

High

382484

MRE11
Double-strand break repair protein MRE11

1

1

Small-scale

0.479

High

382489

NPM
Nucleophosmin

1

1

Small-scale

0.479

High

382492

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

382495

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

Small-scale

0.479

High

382497

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

7

Small-scale

0.479

High

382498

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

14

Small-scale

0.479

High

382500

TOPRS
E3 ubiquitin-protein ligase Topors

1

5

Small-scale

0.479

High

382502

EP400
E1A-binding protein p400

1

9

Small-scale

0.479

High

382503

ZBT7C
Zinc finger and BTB domain-containing protein 7C

1

13

Small-scale

0.479

High

382504

CUL7
Cullin-7

1

5

Small-scale

0.479

High

382509

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

6

Small-scale

0.479

High

382510

FOXP3
Forkhead box protein P3

1

10

High-throughput

0.479

High

382511

PPIF
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

1

4

Small-scale

0.479

High

382512

PARK7
Parkinson disease protein 7 homolog

1

1

Small-scale

0.479

High

382514

RL11
Large ribosomal subunit protein uL5

1

2

Small-scale

0.479

High

382515

RN128
E3 ubiquitin-protein ligase RNF128

1

5

Small-scale

0.479

High

382519

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

1

Small-scale

0.479

High

382521

FAK2
Protein-tyrosine kinase 2-beta

1

8

Small-scale

0.479

High

382522

HIPK2
Homeodomain-interacting protein kinase 2

1

16

Small-scale

0.479

High

382524

PRKN
E3 ubiquitin-protein ligase parkin

1

9

Small-scale

0.479

High

382444

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

Small-scale

0.458

High

382457

DPOG1
DNA polymerase subunit gamma-1

1

0

Small-scale

0.458

High

382518

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

Small-scale

0.458

High

59126

PRD16
Histone-lysine N-methyltransferase PRDM16

1

6

Small-scale

0.445

High

236986

MAPK5
MAP kinase-activated protein kinase 5

1

4

Small-scale

0.445

High

382483

Q60979
SnoN protein

1

2

Small-scale

0.437

High

107944

G3UW74
Mediator of RNA polymerase II transcription subunit 16

1

4

High-throughput

0.417

High


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Last updated: 11Aug2025