HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: TYY1 (P25490)
Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1)
Gene: YY1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 0.60 0.739

The method score is based on:

Property Details
Experiments 17353273, 15210108, 18026119, 25402006, 15295102, 22440256
Identification Methods pull down, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
and 17 others

more...
Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 393
Hs

1 414
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm

Service provided by Combinatics, Japan

Last updated: 11Aug2025