HitPredict

Interactor 1: RB (P06400)
Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)
Gene: RB1

Interactor 2: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.748

Property	Details
Experiments	11306463, 9053846, 1756735, 8626527, 9885575, 9258347, 12361598, 9315635
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0010629 - negative regulation of gene expression and 1 others more... GO:0051301 - cell division
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 928 Hs			1 297
+	Hs
		414172 RB_HUMAN (1-928): 0: 1323: 100.00		CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32
+	Hs
		414244 RB_HUMAN (1-928): 0: 1323: 100.00		CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78
+	Hs
		414246 RB_HUMAN (1-928): 0: 1323: 100.00		CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12
+	Mm
		527147 RB_MOUSE (24-928): 0: 1260: 91.38		CDK2_MOUSE (1-297): 2.06e-140: 401: 55.94
+	Dm
		618441 RBF_DROME (26-860): 0: 684: 21.83		CDK2_DROME (1-290): 5.77e-129: 371: 55.52
+	At
		621707 RBR1_ARATH (19-886): 0: 632: 22.98		CDKA1_ARATH (1-290): 1.2e-137: 392: 67.01
+	At
		639366 RBR1_ARATH (19-886): 0: 632: 22.98		CKB11_ARATH (1-292): 6.81e-132: 378: 52.12
+	At
		1106610 RBR1_ARATH (19-886): 0: 632: 22.98		MPK6_ARATH (9-296): 3.54e-128: 371: 36.05
+	Hs
		625138 RBL1_HUMAN (598-875): 2.06e-76: 272: 28.92		CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32
+	Hs
		625392 RBL2_HUMAN (638-875): 1.32e-58: 220: 26.87		CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32