HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: COP1 (Q8NHY2)
E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
Gene: COP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.757

Property	Details
Experiments	27534417, 29379285, 36650277, 37390815, 16931761, 15103385, 21625211, 23736031
Identification Methods	affinity chromatography technology, pull down, enzymatic study, x-ray crystallography, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, experimental interaction detection
Interaction Type	physical association, direct interaction, association, ubiquitination reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0008270 - zinc ion binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 731
+	Hs
		414354 P53_HUMAN (1-393): 0: 619: 100.00		FBXW7_HUMAN (390-730): 3.04e-83: 280: 16.33
+	Hs
		413533 P53_HUMAN (1-393): 0: 619: 100.00		WDR5_HUMAN (297-625): 1.46e-64: 219: 16.32
+	Hs
		414050 P53_HUMAN (1-393): 0: 619: 100.00		TRAF7_HUMAN (450-730): 2.43e-50: 188: 15.55
+	Hs
		413894 P53_HUMAN (1-393): 0: 619: 100.00		TAF5_HUMAN (524-731): 1.74e-35: 146: 17.23
+	Hs
		413712 P53_HUMAN (1-393): 0: 619: 100.00		RBBP4_HUMAN (512-702): 3.24e-20: 96: 14.49
+	Hs
		1380159 P63_HUMAN (28-363): 2.36e-145: 429: 42.11		FBXW7_HUMAN (390-730): 3.04e-83: 280: 16.33
+	Hs
		413924 P53_HUMAN (1-393): 0: 619: 100.00		RBBP7_HUMAN (476-629): 3.9e-12: 70.9: 29.34
+	Hs
		284915 P53_HUMAN (1-393): 0: 619: 100.00		TAF5L_HUMAN (486-667): 2.49e-11: 68.9: 29.57