HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: CKS1 (P61024)
Cyclin-dependent kinases regulatory subunit 1 (CKS-1)
Gene: CKS1B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.984

Property	Details
Experiments	25416956, 25852190, 26186194, 26496610, 32707033, 36736316, 18471975, 9774639, 23602568, 28514442, 33961781, 19786724, 7809159
Identification Methods	two hybrid, affinity chromatography technology, pull down, mammalian protein protein interaction trap, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005654 - nucleoplasm GO:0048144 - fibroblast proliferation GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 297 Hs			1 79
+	Hs
		625283 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00
+	Hs
		625164 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01
+	Hs
		895413 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00
+	Hs
		706796 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01
+	Hs
		414778 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01
+	At
		188136 CDKA1_ARATH (1-290): 1.2e-137: 392: 67.01		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	Dm
		618415 CDK1_DROME (1-290): 2.24e-136: 389: 73.45		Q9VHN1_DROME (1-71): 6.77e-38: 123: 71.83
+	At
		621728 CDKA1_ARATH (1-290): 1.2e-137: 392: 67.01		CKS2_ARATH (5-78): 3.45e-37: 120: 67.57
+	Hs
		895414 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00
+	Hs
		706797 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01
+	Dm
		618387 CDK1_DROME (1-290): 2.24e-136: 389: 73.45		CKS1_DROME (4-72): 4.45e-35: 115: 78.26
+	At
		188137 CKB11_ARATH (1-292): 6.81e-132: 378: 52.12		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	At
		1321299 CDKD1_ARATH (2-297): 4.98e-131: 379: 47.30		CKS2_ARATH (5-78): 3.45e-37: 120: 67.57
+	At
		639376 CKB11_ARATH (1-292): 6.81e-132: 378: 52.12		CKS2_ARATH (5-78): 3.45e-37: 120: 67.57
+	At
		188156 CKB21_ARATH (1-295): 9.26e-131: 375: 53.14		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	At
		188163 CDKD2_ARATH (1-296): 7.95e-130: 374: 45.61		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	At
		1227962 CKB21_ARATH (1-295): 9.26e-131: 375: 53.14		CKS2_ARATH (5-78): 3.45e-37: 120: 67.57
+	At
		188157 CKB22_ARATH (1-295): 4.69e-130: 373: 57.10		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	At
		1321252 CDKD2_ARATH (1-296): 7.95e-130: 374: 45.61		CKS2_ARATH (5-78): 3.45e-37: 120: 67.57
+	Sp
		383445 CDK1_SCHPO (1-291): 2.43e-132: 378: 63.64		CKS1_SCHPO (4-71): 1.22e-30: 105: 50.65