Protein: MYO5C
Unconventional myosin-Vc

Gene: MYO5C
Organism: Homo sapiens
Interactions: 174
UniProt ID: Q9NQX4

Gene Ontology (top 5):
GO:0000146 - microfilament motor activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0007015 - actin filament organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

702046

TMOD1
Tropomodulin-1

4

7

High-throughput

0.699

High

224805

ACTN4
Alpha-actinin-4

1

8

High-throughput

0.691

High

227979

MYO1B
Unconventional myosin-Ib

1

20

High-throughput

0.691

High

447866

TPM3
Tropomyosin alpha-3 chain

1

1

High-throughput

0.691

High

773040

MYH9
Myosin-9

1

15

High-throughput

0.691

High

862995

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

6

High-throughput

0.691

High

958202

ARP3
Actin-related protein 3

1

12

High-throughput

0.691

High

958357

ARP2
Actin-related protein 2

1

12

High-throughput

0.691

High

993344

ACTG
Actin, cytoplasmic 2

1

9

High-throughput

0.691

High

1091723

MYO1E
Unconventional myosin-Ie

1

20

High-throughput

0.691

High

1117500

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

11

High-throughput

0.691

High

1365601

MY18A
Unconventional myosin-XVIIIa

1

18

High-throughput

0.691

High

1392672

MYO19
Unconventional myosin-XIX

1

19

High-throughput

0.691

High

1434485

ACTL8
Actin-like protein 8

1

10

High-throughput

0.691

High

1447561

CING
Cingulin

1

16

High-throughput

0.691

High

1447568

MYO6
Unconventional myosin-VI

1

18

High-throughput

0.691

High

1447572

MYO5A
Unconventional myosin-Va

1

18

High-throughput

0.691

High

1447556

TMOD3
Tropomodulin-3

3

7

High-throughput

0.675

High

828453

PEX19
Peroxisomal biogenesis factor 19

3

3

High-throughput

0.667

High

1389799

DTBP1
Dysbindin

3

1

High-throughput

0.667

High

1446912

JADE2
E3 ubiquitin-protein ligase Jade-2

3

1

High-throughput

0.667

High

1447304

ANLN
Anillin

3

4

High-throughput

0.667

High

277958

SH3L1
Adapter SH3BGRL

3

2

High-throughput

0.650

High

131080

TULP2
Tubby-related protein 2

2

2

High-throughput

0.628

High

277476

AVIL
Advillin

2

7

High-throughput

0.628

High

749812

CADH5
Cadherin-5

2

2

High-throughput

0.628

High

1352207

DQX1
ATP-dependent RNA helicase homolog DQX1

2

1

High-throughput

0.628

High

1385144

MOAP1
Modulator of apoptosis 1

2

6

High-throughput

0.628

High

1447558

TMOD4
Tropomodulin-4

2

7

High-throughput

0.628

High

956013

RAB8A
Ras-related protein Rab-8A

1

9

Small-scale

0.621

High

464216

TPM2
Tropomyosin beta chain

1

1

High-throughput

0.618

High

630645

RAB3B
Ras-related protein Rab-3B

1

13

High-throughput

0.618

High

976588

RB11A
Ras-related protein Rab-11A

1

9

High-throughput

0.618

High

995837

ACTC
Actin, alpha cardiac muscle 1

1

7

High-throughput

0.618

High

1028889

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

11

High-throughput

0.618

High

230435

CREB3
Cyclic AMP-responsive element-binding protein 3

2

1

High-throughput

0.611

High

647449

SCP2
Sterol carrier protein 2

2

1

High-throughput

0.611

High

867442

CAPZB
F-actin-capping protein subunit beta

2

1

High-throughput

0.611

High

1214575

ACBD5
Acyl-CoA-binding domain-containing protein 5

2

1

High-throughput

0.611

High

331525

SPDEF
SAM pointed domain-containing Ets transcription factor

3

2

High-throughput

0.609

High

284355

GEMI
Geminin

2

0

High-throughput

0.602

High

1093062

CDC16
Cell division cycle protein 16 homolog

2

0

High-throughput

0.602

High

516591

CALM3
Calmodulin-3

1

10

High-throughput

0.575

High

273717

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

2

5

High-throughput

0.574

High

1447562

DKK3
Dickkopf-related protein 3

2

2

High-throughput

0.574

High

1143098

KPCD1
Serine/threonine-protein kinase D1

2

9

High-throughput

0.571

High

131205

CLIC1
Chloride intracellular channel protein 1

1

2

High-throughput

0.536

High

171336

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

3

High-throughput

0.536

High

179252

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

4

High-throughput

0.536

High

179403

ARPC2
Actin-related protein 2/3 complex subunit 2

1

3

High-throughput

0.536

High

179568

ARPC3
Actin-related protein 2/3 complex subunit 3

1

2

High-throughput

0.536

High

192749

ARPC5
Actin-related protein 2/3 complex subunit 5

1

2

High-throughput

0.536

High

212690

DAPK3
Death-associated protein kinase 3

1

7

High-throughput

0.536

High

277409

TP4A3
Protein tyrosine phosphatase type IVA 3

1

4

High-throughput

0.536

High

300843

KRT38
Keratin, type I cuticular Ha8

1

14

High-throughput

0.536

High

336490

SVIL
Supervillin

1

7

High-throughput

0.536

High

354037

CX001
Putative transmembrane protein CXorf1

1

2

High-throughput

0.536

High

537963

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.536

High

637751

FLNA
Filamin-A

1

9

High-throughput

0.536

High

777567

K22E
Keratin, type II cytoskeletal 2 epidermal

1

4

High-throughput

0.536

High

866836

CAZA2
F-actin-capping protein subunit alpha-2

1

6

High-throughput

0.536

High

915195

CAZA1
F-actin-capping protein subunit alpha-1

1

6

High-throughput

0.536

High

931127

HSP72
Heat shock-related 70 kDa protein 2

1

3

High-throughput

0.536

High

967992

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

8

High-throughput

0.536

High

968455

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

8

High-throughput

0.536

High

983985

RBX1
E3 ubiquitin-protein ligase RBX1

1

3

High-throughput

0.536

High

1052106

CALD1
Caldesmon

1

19

High-throughput

0.536

High

1082573

NEXN
Nexilin

1

9

High-throughput

0.536

High

1093319

FLII
Protein flightless-1 homolog

1

7

High-throughput

0.536

High

1095947

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

3

High-throughput

0.536

High

1120829

DSG2
Desmoglein-2

1

1

High-throughput

0.536

High

1124731

SRC8
Src substrate cortactin

1

5

High-throughput

0.536

High

1160766

DREB
Drebrin

1

3

High-throughput

0.536

High

1202249

DCAF6
DDB1- and CUL4-associated factor 6

1

5

High-throughput

0.536

High

1208072

CYTSB
Cytospin-B

1

19

High-throughput

0.536

High

1213092

RHG21
Rho GTPase-activating protein 21

1

1

High-throughput

0.536

High

1229876

CYTSA
Cytospin-A

1

17

High-throughput

0.536

High

1289989

LUZP1
Leucine zipper protein 1

1

20

High-throughput

0.536

High

1325453

SYNPO
Synaptopodin

1

5

High-throughput

0.536

High

1334181

POC1A
POC1 centriolar protein homolog A

1

2

High-throughput

0.536

High

1382539

TRI52
E3 ubiquitin-protein ligase TRIM52

1

3

High-throughput

0.536

High

1397249

LURA1
Leucine rich adaptor protein 1

1

1

High-throughput

0.536

High

1407273

ATP5S
ATP synthase subunit s, mitochondrial

1

1

High-throughput

0.536

High

1409691

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

1

2

High-throughput

0.536

High

1411030

COR1B
Coronin-1B

1

5

High-throughput

0.536

High

1447551

PDLI7
PDZ and LIM domain protein 7

1

4

High-throughput

0.536

High

1447557

CLIC5
Chloride intracellular channel protein 5

1

2

High-throughput

0.536

High

1447563

LIMA1
LIM domain and actin-binding protein 1

1

3

High-throughput

0.536

High

1447570

PLAK2
PALM2-AKAP2 fusion protein

1

1

High-throughput

0.536

High

1447571

CRYL1
Lambda-crystallin homolog

1

1

High-throughput

0.536

High

882913

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.515

High

1144483

NONO
Non-POU domain-containing octamer-binding protein

1

2

High-throughput

0.515

High

274387

SIN3B
Paired amphipathic helix protein Sin3b

1

0

High-throughput

0.513

High

344806

AP2A1
AP-2 complex subunit alpha-1

1

0

High-throughput

0.513

High

365476

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.513

High

391478

FRIL
Ferritin light chain

1

0

High-throughput

0.513

High

873418

LSS
Lanosterol synthase

1

0

High-throughput

0.513

High

1195333

TPRN
Taperin

1

0

High-throughput

0.513

High

1309173

MISP
Mitotic interactor and substrate of PLK1

1

0

High-throughput

0.513

High

1327353

AFAP1
Actin filament-associated protein 1

1

0

High-throughput

0.513

High

1447554

T161A
Transmembrane protein 161A

1

0

High-throughput

0.513

High

1447569

ABCG2
Broad substrate specificity ATP-binding cassette transporter ABCG2

1

0

High-throughput

0.513

High

384558

CRYAA
Alpha-crystallin A chain

1

8

High-throughput

0.501

High

426581

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.493

High

1447555

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.493

High

175995

N4BP3
NEDD4-binding protein 3

1

13

High-throughput

0.489

High

317089

DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein

1

2

High-throughput

0.489

High

373237

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.489

High

1009626

CXCL6
C-X-C motif chemokine 6

1

2

High-throughput

0.489

High

1093774

GAGE5
G antigen 5

1

2

High-throughput

0.489

High

1177096

INF2
Inverted formin-2

1

2

High-throughput

0.489

High

1215515

CE162
Centrosomal protein of 162 kDa

1

19

High-throughput

0.489

High

1230274

K1C40
Keratin, type I cytoskeletal 40

1

13

High-throughput

0.489

High

1388100

ERLEC
Endoplasmic reticulum lectin 1

1

2

High-throughput

0.489

High

1389601

SAAL1
Protein SAAL1

1

2

High-throughput

0.489

High

1397806

ODAD1
Outer dynein arm-docking complex subunit 1

1

16

High-throughput

0.489

High

1447552

BRWD1
Bromodomain and WD repeat-containing protein 1

1

2

High-throughput

0.489

High

1447559

RAI14
Ankycorbin

1

4

High-throughput

0.489

High

1447565

PNMA2
Paraneoplastic antigen Ma2

1

6

High-throughput

0.489

High

1447566

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.489

High

1447567

NP1L2
Nucleosome assembly protein 1-like 2

1

1

High-throughput

0.489

High

1447573

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

18

High-throughput

0.489

High

1447574

NEMO
NF-kappa-B essential modulator

1

18

High-throughput

0.481

High

164105

NDC80
Kinetochore protein NDC80 homolog

1

17

High-throughput

0.479

High

323576

TRI37
E3 ubiquitin-protein ligase TRIM37

1

13

High-throughput

0.479

High

414685

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

425639

ISG15
Ubiquitin-like protein ISG15

1

5

High-throughput

0.479

High

437014

K1C18
Keratin, type I cytoskeletal 18

1

6

High-throughput

0.479

High

459765

PROF1
Profilin-1

1

1

High-throughput

0.479

High

475697

K1C19
Keratin, type I cytoskeletal 19

1

5

High-throughput

0.479

High

520397

ANDR
Androgen receptor

1

12

High-throughput

0.479

High

552705

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.479

High

582975

EZRI
Ezrin

1

7

High-throughput

0.479

High

688168

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.479

High

786869

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

9

High-throughput

0.479

High

831486

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

873328

COPD
Coatomer subunit delta

1

1

High-throughput

0.479

High

898256

R144A
E3 ubiquitin-protein ligase RNF144A

1

2

Small-scale

0.479

High

979274

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

1035934

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

1095814

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

17

Small-scale

0.479

High

1114388

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1125238

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

4

High-throughput

0.479

High

1140915

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

1325358

T132C
Transmembrane protein 132C

1

1

High-throughput

0.479

High

1430591

CCDC8
Coiled-coil domain-containing protein 8

1

6

High-throughput

0.479

High

1433978

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.479

High

1436495

ECT2
Protein ECT2

1

4

High-throughput

0.479

High

278970

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

317002

MTA2
Metastasis-associated protein MTA2

1

0

High-throughput

0.458

High

961415

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.458

High

1055367

APLP2
Amyloid beta precursor like protein 2

1

0

High-throughput

0.458

High

1110733

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

1439200

AGO4
Protein argonaute-4

1

0

High-throughput

0.458

High

58944

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

3

High-throughput

0.445

High

530422

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

564416

CFTR
Cystic fibrosis transmembrane conductance regulator

1

11

High-throughput

0.445

High

370789

FOS
Protein c-Fos

1

3

High-throughput

0.437

High

576683

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

1

High-throughput

0.437

High

1138085

TNIP1
TNFAIP3-interacting protein 1

1

13

High-throughput

0.437

High

1197570

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

8

High-throughput

0.437

High

1250201

LRC31
Leucine-rich repeat-containing protein 31

1

5

High-throughput

0.437

High

1447564

ANC2
Anaphase-promoting complex subunit 2

1

4

High-throughput

0.437

High

255227

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.407

High

191400

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.279

Low

333525

MPZL1
Myelin protein zero-like protein 1

1

0

High-throughput

0.279

Low

483401

CLCB
Clathrin light chain B

1

0

High-throughput

0.279

Low

1242426

RHGBA
Rho GTPase-activating protein 11A

1

0

High-throughput

0.279

Low

1251516

CD109
CD109 antigen

1

0

High-throughput

0.279

Low

1337294

ACRBP
Acrosin-binding protein

1

0

High-throughput

0.279

Low

1447553

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.251

Low

1235259

ANO7
Anoctamin-7

1

0

Small-scale

0.249

Low

1447560

SEP10
Septin-10

1

0

High-throughput

0.249

Low

1167117

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025