HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: CDT1 (Q9H211)
DNA replication factor Cdt1 (Double parked homolog) (DUP)
Gene: CDT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.703

Property	Details
Experiments	26186194, 28514442, 31160578, 14993212
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045740 - positive regulation of DNA replication GO:0051301 - cell division
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 546
+	Hs
		625596 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CDT1_HUMAN (1-546): 0: 656: 100.00
+	Hs
		960120 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		CDT1_HUMAN (1-546): 0: 656: 100.00
+	Dm
		618447 CDK2_DROME (1-290): 5.77e-129: 371: 55.52		Q7JVY2_DROME (166-543): 8.27e-124: 382: 32.89