HitPredict

Interactor 1: CO2 (P06681)
Complement C2 (EC 3.4.21.43) (C3/C5 convertase) [Cleaved into: Complement C2b fragment; Complement C2a fragment]
Gene: C2

Interactor 2: CO4A (P0C0L4)
Complement C4-A (Acidic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2) [Cleaved into: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain]
Gene: C4A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.778

The method score is based on:

Property Details
Experiments 10946278, 11341920
Identification Methods pull down
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains A2M~Sushi, A2M_BRD~Sushi, MG2~Sushi, MG4~Sushi, NTR~Sushi, Sushi~TED_complement, A2M_recep~Trypsin, MG2~Trypsin, NTR~VWA, TED_complement~VWA
Common GO terms GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006956 - complement activation
GO:0006958 - complement activation, classical pathway
GO:0045087 - innate immune response
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 752
Hs

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Last updated: 15 Jul 2024