Interactor 1: SIR2 (P06700)
NAD-dependent histone deacetylase SIR2 (EC 2.3.1.286) (Regulatory protein SIR2) (Silent information regulator 2)
Gene: SIR2
Interactor 2: SIR4 (P11978)
Regulatory protein SIR4 (Silent information regulator 4)
Gene: SIR4
Species: Saccharomyces cerevisiae S288C
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.98 | 1.00 | 0.993 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 9000052, 9122169, 11805837, 11805826, 8752220, 12024030, 11500379, 15282295, 26319015, 16956377, 19217406, 19782027, 21822217, 21896656, 22654676, 23299941, 10219245, 10757754, 10835361, 16554755 and 10 others
more... |
| Identification Methods | experimental interaction detection, two hybrid, affinity chromatography technology, coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification, pull down, biochemical, x-ray crystallography |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | DUF592~SIR4_SID, SIR2~SIR4_SID |
| Common GO terms | GO:0000781 - chromosome, telomeric region GO:0005677 - chromatin silencing complex GO:0006303 - double-strand break repair via nonhomologous end joining GO:0030466 - silent mating-type cassette heterochromatin formation GO:0031507 - heterochromatin formation and 3 others more... |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
