Protein: SYNC
Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS)

Gene: SYNC, DED81
Organism: Saccharomyces cerevisiae S288C
Interactions: 168
UniProt ID: P38707

Gene Ontology (top 5):
GO:0004816 - asparagine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006421 - asparaginyl-tRNA aminoacylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

416230

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

13

High-throughput

0.618

High

581855

SYKC
Lysine--tRNA ligase, cytoplasmic

1

14

High-throughput

0.618

High

802538

YHI0
Putative proline--tRNA ligase YHR020W

2

9

High-throughput

0.611

High

802542

RPN10
26S proteasome regulatory subunit RPN10

2

2

High-throughput

0.611

High

802562

GCN20
Protein GCN20

2

6

High-throughput

0.611

High

802564

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

4

High-throughput

0.584

High

394519

EF1A
Elongation factor 1-alpha

2

3

High-throughput

0.571

High

597449

EF3A
Elongation factor 3A

2

8

High-throughput

0.571

High

802540

RPN1
26S proteasome regulatory subunit RPN1

2

4

High-throughput

0.571

High

575724

BPT1
Bile pigment transporter 1

1

2

High-throughput

0.541

High

481883

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

11

High-throughput

0.536

High

531319

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.536

High

688875

RS5
Small ribosomal subunit protein uS7

1

1

High-throughput

0.536

High

721911

XPO1
Exportin-1

1

2

High-throughput

0.536

High

734089

EF2
Elongation factor 2

1

4

High-throughput

0.536

High

747338

RSSA1
Small ribosomal subunit protein uS2A

1

5

High-throughput

0.536

High

750185

UFD4
Ubiquitin fusion degradation protein 4

1

10

High-throughput

0.536

High

755087

GCN1
eIF-2-alpha kinase activator GCN1

1

4

High-throughput

0.536

High

778879

PTK1
Serine/threonine-protein kinase PTK1/STK1

1

1

High-throughput

0.536

High

802539

ECM29
Proteasome component ECM29

1

2

High-throughput

0.536

High

802558

IST3
U2 snRNP component IST3

1

1

High-throughput

0.536

High

802582

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

7

High-throughput

0.536

High

802587

CLU
Clustered mitochondria protein 1

1

1

High-throughput

0.536

High

802590

RPN9
26S proteasome regulatory subunit RPN9

1

1

High-throughput

0.536

High

802602

NEW1
[NU+] prion formation protein 1

1

7

High-throughput

0.536

High

802605

MDN1
Midasin

1

2

High-throughput

0.536

High

670664

SIS1
Protein SIS1

1

3

High-throughput

0.515

High

486161

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.513

High

802547

TCPD
T-complex protein 1 subunit delta

1

0

High-throughput

0.513

High

802552

GEA2
ARF guanine-nucleotide exchange factor 2

1

0

High-throughput

0.513

High

802555

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.513

High

802560

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

802573

SGF73
SAGA complex subunit SGF73

1

0

High-throughput

0.513

High

470520

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

3

High-throughput

0.489

High

575445

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

1

High-throughput

0.489

High

625006

PRP6
Pre-mRNA-splicing factor 6

1

3

High-throughput

0.489

High

740155

RPN2
26S proteasome regulatory subunit RPN2

1

4

High-throughput

0.489

High

802557

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

802572

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

High-throughput

0.489

High

149738

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

368894

SYMC
Methionine--tRNA ligase, cytoplasmic

1

15

High-throughput

0.479

High

392671

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.479

High

416118

SYTC
Threonine--tRNA ligase, cytoplasmic

1

10

High-throughput

0.479

High

433617

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.479

High

435062

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

438683

SC160
Protein SCP160

1

3

High-throughput

0.479

High

454164

SYH
Histidine--tRNA ligase, mitochondrial

1

3

High-throughput

0.479

High

455037

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.479

High

460338

SYV
Valine--tRNA ligase, mitochondrial

1

10

High-throughput

0.479

High

503018

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.479

High

512984

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.479

High

515249

RL35A
Large ribosomal subunit protein uL29A

1

1

High-throughput

0.479

High

558703

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.479

High

560798

SYQ
Glutamine--tRNA ligase

1

14

High-throughput

0.479

High

579328

HSC82
ATP-dependent molecular chaperone HSC82

1

7

High-throughput

0.479

High

632889

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

3

High-throughput

0.479

High

657083

IF5A1
Eukaryotic translation initiation factor 5A-1

1

6

High-throughput

0.479

High

668314

IF2M
Translation initiation factor IF-2, mitochondrial

1

9

High-throughput

0.479

High

671922

RBSK
Ribokinase

1

2

High-throughput

0.479

High

674596

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

679637

CDC48
Cell division control protein 48

1

5

High-throughput

0.479

High

687585

SYLC
Leucine--tRNA ligase, cytoplasmic

1

14

High-throughput

0.479

High

709736

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

713615

EF1G1
Elongation factor 1-gamma 1

1

9

High-throughput

0.479

High

726994

HS104
Heat shock protein 104

1

4

High-throughput

0.479

High

735999

SP110
Spindle pole body component 110

1

4

High-throughput

0.479

High

739356

ZUO1
Zuotin

1

5

High-throughput

0.479

High

747830

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

750645

PRS6A
26S proteasome regulatory subunit 6A

1

7

High-throughput

0.479

High

753346

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.479

High

778303

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

779047

EF1G2
Elongation factor 1-gamma 2

1

7

High-throughput

0.479

High

780948

SPC42
Spindle pole body component SPC42

1

2

High-throughput

0.479

High

783471

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

5

High-throughput

0.479

High

785915

LONM
Lon protease homolog, mitochondrial

1

8

High-throughput

0.479

High

792021

GBLP
Small ribosomal subunit protein RACK1

1

8

High-throughput

0.479

High

792345

AHP1
Peroxiredoxin AHP1

1

1

High-throughput

0.479

High

793317

SYG
Glycine--tRNA ligase 1, mitochondrial

1

12

High-throughput

0.479

High

796145

OLA1
Obg-like ATPase 1

1

2

High-throughput

0.479

High

802541

SSZ1
Ribosome-associated complex subunit SSZ1

1

4

High-throughput

0.479

High

802543

IF1A
Eukaryotic translation initiation factor 1A

1

1

High-throughput

0.479

High

802546

ATU2
Copper-transporting ATPase

1

1

High-throughput

0.479

High

802548

CAJ1
Protein CAJ1

1

2

High-throughput

0.479

High

802549

DHH1
ATP-dependent RNA helicase DHH1

1

4

High-throughput

0.479

High

802550

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.479

High

802556

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

2

High-throughput

0.479

High

802563

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

802565

LSB3
LAS seventeen-binding protein 3

1

5

High-throughput

0.479

High

802566

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

14

High-throughput

0.479

High

802567

ARC1
tRNA-aminoacylation cofactor ARC1

1

8

High-throughput

0.479

High

802569

DENR
Translation machinery-associated protein 22

1

2

High-throughput

0.479

High

802571

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.479

High

802575

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

802576

SPC98
Spindle pole body component SPC98

1

2

High-throughput

0.479

High

802577

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

2

High-throughput

0.479

High

802579

PDR16
Phosphatidylinositol transfer protein PDR16

1

2

High-throughput

0.479

High

802581

TMA20
Translation machinery-associated protein 20

1

2

High-throughput

0.479

High

802583

MAP1
Methionine aminopeptidase 1

1

2

High-throughput

0.479

High

802584

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

802585

RLI1
Translation initiation factor RLI1

1

7

High-throughput

0.479

High

802586

TOM1
E3 ubiquitin-protein ligase TOM1

1

7

High-throughput

0.479

High

802589

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

802591

RM34
Large ribosomal subunit protein bL34m

1

2

High-throughput

0.479

High

802596

LAM6
Membrane-anchored lipid-binding protein LAM6

1

1

High-throughput

0.479

High

802599

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.479

High

802606

MDY2
Ubiquitin-like protein MDY2

1

2

High-throughput

0.479

High

802607

DBP10
ATP-dependent RNA helicase DBP10

1

8

High-throughput

0.479

High

802609

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.479

High

410106

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

434559

RL22A
Large ribosomal subunit protein eL22A

1

0

High-throughput

0.458

High

504188

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.458

High

689429

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

781178

RL14A
Large ribosomal subunit protein eL14A

1

0

High-throughput

0.458

High

802603

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

427258

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.445

High

439325

PDC1
Pyruvate decarboxylase isozyme 1

1

1

High-throughput

0.445

High

450579

FAS1
Fatty acid synthase subunit beta

1

1

High-throughput

0.445

High

453578

PYR1
Multifunctional protein URA2

1

4

High-throughput

0.445

High

592227

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

741503

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.445

High

750836

PRS6B
26S proteasome regulatory subunit 6B homolog

1

5

High-throughput

0.445

High

750936

PRS7
26S proteasome regulatory subunit 7 homolog

1

11

High-throughput

0.445

High

802553

IMB4
Importin subunit beta-4

1

3

High-throughput

0.445

High

802554

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

802561

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.445

High

802578

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.445

High

802611

VPS5
Vacuolar protein sorting-associated protein 5

1

0

High-throughput

0.438

High

394043

EFTU
Elongation factor Tu, mitochondrial

1

10

High-throughput

0.437

High

452020

TOM70
Mitochondrial import receptor subunit TOM70

1

8

High-throughput

0.437

High

619160

IF5A2
Eukaryotic translation initiation factor 5A-2

1

6

High-throughput

0.437

High

637325

ATP5E
ATP synthase subunit epsilon, mitochondrial

1

2

High-throughput

0.437

High

706995

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

736378

MET4
Transcriptional activator of sulfur metabolism MET4

1

2

High-throughput

0.437

High

746830

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

3

High-throughput

0.437

High

792606

RM16
Large ribosomal subunit protein uL16m

1

2

High-throughput

0.437

High

802545

SEC31
Protein transport protein SEC31

1

9

High-throughput

0.437

High

802551

SIT1
Siderophore iron transporter 1

1

5

High-throughput

0.437

High

802559

MMM1
Maintenance of mitochondrial morphology protein 1

1

2

High-throughput

0.437

High

802570

HOSC
Homocitrate synthase, cytosolic isozyme

1

3

High-throughput

0.437

High

802574

EIF2A
Eukaryotic translation initiation factor 2A

1

2

High-throughput

0.437

High

802580

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.437

High

802588

YMC0
Uncharacterized protein YML020W

1

2

High-throughput

0.437

High

802593

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

802597

ENB1
Siderophore iron transporter ENB1

1

5

High-throughput

0.437

High

802600

TIM18
Mitochondrial import inner membrane translocase subunit TIM18

1

2

High-throughput

0.437

High

802601

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

802604

TRMB
tRNA

1

2

High-throughput

0.437

High

802608

EMC6
ER membrane protein complex subunit 6

1

2

High-throughput

0.437

High

802610

RKM4
Ribosomal lysine N-methyltransferase 4

1

2

High-throughput

0.437

High

802612

MED11
Mediator of RNA polymerase II transcription subunit 11

1

2

High-throughput

0.437

High

365031

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.426

High

386697

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

684708

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

382079

H4
Histone H4

1

1

High-throughput

0.407

High

438426

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

2

High-throughput

0.407

High

644920

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

3

High-throughput

0.407

High

732137

COPG
Coatomer subunit gamma

1

1

High-throughput

0.407

High

702245

YJU2
Splicing factor YJU2

1

0

High-throughput

0.279

Low

748166

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.279

Low

802568

GWT1
GPI-anchored wall transfer protein 1

1

0

High-throughput

0.279

Low

802598

DIA2
Protein DIA2

1

0

High-throughput

0.279

Low

763880

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

802594

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

735714

VA0D
V-type proton ATPase subunit d

1

0

High-throughput

0.232

Low

738302

RPN12
26S proteasome regulatory subunit RPN12

1

0

High-throughput

0.232

Low

802544

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.232

Low

802592

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.232

Low

802595

CRLS1
Cardiolipin synthase

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025