HitPredict

Interactor 1: S10A9 (P06702)
Protein S100-A9 (Calgranulin-B) (Calprotectin L1H subunit) (Leukocyte L1 complex heavy chain) (Migration inhibitory factor-related protein 14) (MRP-14) (p14) (S100 calcium-binding protein A9)
Gene: S100A9

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	24189400, 19380743
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0042742 - defense response to bacterium
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 114 Hs			1 583
+	Hs
		396686 S10A8_HUMAN (5-100): 3.01e-29: 102: 25.00		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		416576 S10A6_HUMAN (7-96): 3.05e-27: 97.7: 31.11		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		666006 S10A7_HUMAN (6-105): 8.64e-26: 94.2: 24.75		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		380729 S100B_HUMAN (5-97): 2.99e-31: 107: 37.63		VAV_HUMAN (163-578): 1.81e-54: 200: 12.25
+	Hs
		661266 S10A2_HUMAN (1-101): 2.02e-32: 110: 32.67		SHB_HUMAN (369-579): 2.01e-41: 158: 20.63
+	Hs
		678424 S10A7_HUMAN (6-105): 8.64e-26: 94.2: 24.75		BMX_HUMAN (341-582): 1.11e-38: 153: 19.69
+	Mm
		140056 S10AA_MOUSE (6-104): 2.43e-33: 113: 29.29		P85B_MOUSE (358-581): 2.77e-30: 128: 16.67
+	Hs
		416505 S10A9_HUMAN (1-114): 4.07e-47: 148: 100.00		SH23A_HUMAN (475-581): 3.64e-17: 86.8: 33.06
+	Hs
		416396 S10A9_HUMAN (1-114): 4.07e-47: 148: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		639060 S100P_HUMAN (5-97): 2.82e-35: 118: 36.56		SH23A_HUMAN (475-581): 3.64e-17: 86.8: 33.06
+	Hs
		1125343 FILA2_HUMAN (5-106): 5.21e-28: 108: 30.91		SH23A_HUMAN (475-581): 3.64e-17: 86.8: 33.06
+	Hs
		396795 S10A8_HUMAN (5-100): 3.01e-29: 102: 25.00		SH23A_HUMAN (475-581): 3.64e-17: 86.8: 33.06
+	Hs
		596312 FILA_HUMAN (5-107): 2e-23: 95.4: 34.62		SH23A_HUMAN (475-581): 3.64e-17: 86.8: 33.06
+	Hs
		678499 S10A7_HUMAN (6-105): 8.64e-26: 94.2: 24.75		SH23A_HUMAN (475-581): 3.64e-17: 86.8: 33.06
+	Hs
		396713 S10A8_HUMAN (5-100): 3.01e-29: 102: 25.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		416603 S10A6_HUMAN (7-96): 3.05e-27: 97.7: 31.11		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48