Protein: HXKB
Hexokinase-2 (EC 2.7.1.1) (Hexokinase PII) (Hexokinase-B)

Gene: HXKB, HXK2
Organism: Saccharomyces cerevisiae S288C
Interactions: 95
UniProt ID: P04807

Gene Ontology (top 5):
GO:0001678 - intracellular glucose homeostasis
GO:0004340 - glucokinase activity
GO:0004396 - hexokinase activity
GO:0005524 - ATP binding
GO:0005536 - D-glucose binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

416499

HXKB
Hexokinase-2

3

14

Small-scale

0.849

High

416327

HXKA
Hexokinase-1

3

14

High-throughput

0.836

High

416525

MIG1
Regulatory protein MIG1

4

1

Small-scale

0.698

High

416502

SNF1
Carbon catabolite-derepressing protein kinase

4

1

Small-scale

0.694

High

416527

XPO1
Exportin-1

2

2

Small-scale

0.624

High

416564

IMA1
Importin subunit alpha

2

1

Small-scale

0.624

High

416553

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.584

High

416582

CMR1
DNA damage-binding protein CMR1

1

1

High-throughput

0.552

High

416561

REG1
Resistance to glucose repression protein 1

2

0

Small-scale

0.551

High

416539

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

Small-scale

0.549

High

416569

IMB1
Importin subunit beta-1

1

0

Small-scale

0.537

High

416533

RGT1
Glucose transport transcription regulator RGT1

1

0

Small-scale

0.529

High

416515

SPO12
Sporulation-specific protein 12

1

0

High-throughput

0.513

High

416562

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

416567

TDA1
Serine/threonine-protein kinase TDA1

1

3

Small-scale

0.501

High

416516

PRP6
Pre-mRNA-splicing factor 6

1

3

High-throughput

0.500

High

416517

FKBP
FK506-binding protein 1

1

1

High-throughput

0.500

High

416530

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.500

High

416532

PP12
Serine/threonine-protein phosphatase PP1-2

1

4

High-throughput

0.500

High

416543

DUN1
DNA damage response protein kinase DUN1

1

5

High-throughput

0.500

High

416545

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.500

High

416546

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

1

2

High-throughput

0.500

High

416580

ATG5
Autophagy protein 5

1

2

High-throughput

0.500

High

416583

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.500

High

416549

RT106
Histone chaperone RTT106

1

0

High-throughput

0.493

High

416558

THO2
THO complex subunit 2

1

0

High-throughput

0.493

High

416578

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

0

High-throughput

0.493

High

416551

MPH1
ATP-dependent DNA helicase MPH1

1

1

Small-scale

0.481

High

416559

RHO5
GTP-binding protein RHO5

1

5

Small-scale

0.481

High

416509

AAKG
5'-AMP-activated protein kinase subunit gamma

1

0

Small-scale

0.480

High

416568

GAL83
SNF1 protein kinase subunit beta-3

1

0

Small-scale

0.480

High

358926

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

3

High-throughput

0.479

High

361404

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.479

High

365514

PGK
Phosphoglycerate kinase

1

1

High-throughput

0.479

High

367638

ENO1
Enolase 1

1

5

High-throughput

0.479

High

367839

ENO2
Enolase 2

1

5

High-throughput

0.479

High

391956

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.479

High

409811

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

416501

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

416504

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.479

High

416508

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.479

High

416511

ALF
Fructose-bisphosphate aldolase

1

1

High-throughput

0.479

High

416512

TAL1
Transaldolase

1

1

High-throughput

0.479

High

416513

HSC82
ATP-dependent molecular chaperone HSC82

1

7

High-throughput

0.479

High

416518

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

416519

SIS1
Protein SIS1

1

5

High-throughput

0.479

High

416522

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

416524

CDC48
Cell division control protein 48

1

4

High-throughput

0.479

High

416526

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

416528

HS104
Heat shock protein 104

1

5

High-throughput

0.479

High

416535

PRS6A
26S proteasome regulatory subunit 6A

1

2

High-throughput

0.479

High

416538

TCTP
Translationally-controlled tumor protein homolog

1

2

High-throughput

0.479

High

416541

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

416542

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

416544

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

416547

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.479

High

416550

MMF1
Protein MMF1, mitochondrial

1

1

High-throughput

0.479

High

416556

MIG2
Regulatory protein MIG2

1

2

Small-scale

0.479

High

416557

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

416560

SAM50
Sorting assembly machinery 50 kDa subunit

1

2

High-throughput

0.479

High

416563

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

416566

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

416570

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

416572

ZEO1
Protein ZEO1

1

1

High-throughput

0.479

High

416577

RTK1
Probable serine/threonine-protein kinase RTK1

1

1

High-throughput

0.479

High

416579

RRP6
Exosome complex exonuclease RRP6

1

5

High-throughput

0.479

High

416581

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.479

High

383390

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

416500

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

416503

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

416514

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

416529

P5CR
Pyrroline-5-carboxylate reductase

1

0

High-throughput

0.458

High

416540

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

416552

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

416555

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

416574

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

416576

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

416521

CDC10
Cell division control protein 10

1

2

High-throughput

0.457

High

416505

HSP71
Heat shock protein SSA1

1

10

High-throughput

0.445

High

416506

HSP72
Heat shock protein SSA2

1

10

High-throughput

0.445

High

416507

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.445

High

416523

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.445

High

416531

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.445

High

416536

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.445

High

416537

MDJ1
DnaJ homolog 1, mitochondrial

1

3

High-throughput

0.445

High

416548

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

416573

RBX1
RING-box protein HRT1

1

0

High-throughput

0.438

High

416510

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.437

High

416565

COFI
Cofilin

1

2

High-throughput

0.437

High

416571

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

416575

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

416520

SCJ1
DnaJ-related protein SCJ1

1

3

High-throughput

0.407

High

416534

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.261

Low

416554

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025