Protein: ALF
Fructose-bisphosphate aldolase (FBP aldolase) (FBPA) (EC 4.1.2.13) (Fructose-1,6-bisphosphate aldolase)

Gene: ALF, FBA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 232
UniProt ID: P14540

Gene Ontology (top 5):
GO:0004332 - fructose-bisphosphate aldolase activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0006094 - gluconeogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

402182

RPC1
DNA-directed RNA polymerase III subunit RPC1

3

1

Small-scale

0.662

High

572520

SIS1
Protein SIS1

3

2

High-throughput

0.643

High

572497

ALF
Fructose-bisphosphate aldolase

1

1

High-throughput

0.618

High

572611

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

0

High-throughput

0.613

High

543667

SSB1
Ribosome-associated molecular chaperone SSB1

2

2

High-throughput

0.611

High

572642

GCN5
Histone acetyltransferase GCN5

2

0

High-throughput

0.602

High

359418

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

2

3

Small-scale

0.588

High

365542

PGK
Phosphoglycerate kinase

2

1

Small-scale

0.588

High

522915

HSP71
Heat shock protein SSA1

2

2

High-throughput

0.571

High

525805

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.571

High

572501

HSC82
ATP-dependent molecular chaperone HSC82

2

2

High-throughput

0.571

High

572526

MAS5
Mitochondrial protein import protein MAS5

2

2

High-throughput

0.571

High

572629

RHO5
GTP-binding protein RHO5

2

0

Small-scale

0.569

High

572631

FAR11
Factor arrest protein 11

2

0

High-throughput

0.563

High

572595

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.552

High

572635

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

477500

MYO1
Myosin-1

1

0

Small-scale

0.529

High

572620

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

0

High-throughput

0.513

High

572627

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

572645

ACL4
Assembly chaperone of RPL4

1

0

High-throughput

0.513

High

572653

ASR1
Alcohol-sensitive RING finger protein 1

1

0

High-throughput

0.513

High

572506

GLRX2
Glutaredoxin-2

1

1

Small-scale

0.501

High

572523

GLRX1
Glutaredoxin-1

1

1

Small-scale

0.501

High

518185

IF4A
ATP-dependent RNA helicase eIF4A

1

1

High-throughput

0.500

High

572505

PHO85
Cyclin-dependent protein kinase PHO85

1

1

High-throughput

0.500

High

572657

RTC1
Restriction of telomere capping protein 1

1

1

High-throughput

0.500

High

572676

AP2M
AP-2 complex subunit mu

1

1

High-throughput

0.500

High

506361

NFT1
ABC transporter NFT1

1

1

High-throughput

0.494

High

572553

PXA2
Peroxisomal long-chain fatty acid import protein 1

1

1

High-throughput

0.494

High

572608

PXA1
Peroxisomal long-chain fatty acid import protein 2

1

2

High-throughput

0.494

High

517868

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.480

High

441316

KAPB
cAMP-dependent protein kinase type 2

1

0

High-throughput

0.479

High

536068

ARF1
ADP-ribosylation factor 1

1

0

High-throughput

0.479

High

572499

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.479

High

572511

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.479

High

572513

PP11
Serine/threonine-protein phosphatase PP1-1

1

0

High-throughput

0.479

High

572521

MSH3
DNA mismatch repair protein MSH3

1

0

High-throughput

0.479

High

572538

CDC12
Cell division control protein 12

1

0

High-throughput

0.479

High

572541

DUR1
Urea amidolyase [Includes: Urea carboxylase

1

0

High-throughput

0.479

High

572543

PP12
Serine/threonine-protein phosphatase PP1-2

1

0

High-throughput

0.479

High

572544

FIMB
Fimbrin

1

0

High-throughput

0.479

High

572550

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.479

High

572565

IMB2
Importin subunit beta-2

1

0

High-throughput

0.479

High

572583

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.479

High

572586

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.479

High

572613

SA155
SIT4-associating protein SAP155

1

0

High-throughput

0.479

High

572623

RPN14
26S proteasome regulatory subunit RPN14

1

0

High-throughput

0.479

High

572639

IMA1
Importin subunit alpha

1

0

High-throughput

0.479

High

572654

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.479

High

572670

ATG5
Autophagy protein 5

1

0

High-throughput

0.479

High

358952

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

3

High-throughput

0.479

High

359133

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

3

High-throughput

0.479

High

364295

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.479

High

364897

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.479

High

367669

ENO1
Enolase 1

1

1

High-throughput

0.479

High

367874

ENO2
Enolase 2

1

1

High-throughput

0.479

High

368571

PMG1
Phosphoglycerate mutase 1

1

1

High-throughput

0.479

High

392134

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.479

High

416356

HXKA
Hexokinase-1

1

1

High-throughput

0.479

High

416511

HXKB
Hexokinase-2

1

1

High-throughput

0.479

High

510140

HSP77
Import motor subunit, mitochondrial

1

3

High-throughput

0.479

High

531224

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.479

High

572510

METK2
S-adenosylmethionine synthase 2

1

1

High-throughput

0.479

High

572516

KCC2
Calcium/calmodulin-dependent protein kinase II

1

1

High-throughput

0.479

High

572628

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.479

High

149552

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

361413

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.458

High

366698

HIS2
Histidine biosynthesis trifunctional protein [Includes: Phosphoribosyl-AMP cyclohydrolase

1

0

High-throughput

0.458

High

368396

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

409902

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

427117

RLA0
Large ribosomal subunit protein uL10

1

0

Small-scale

0.458

High

432279

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.458

High

433410

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

434775

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

439217

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

441668

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

450696

KAD2
Adenylate kinase

1

0

High-throughput

0.458

High

454065

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.458

High

454687

KAPR
cAMP-dependent protein kinase regulatory subunit

1

0

Small-scale

0.458

High

454834

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

481843

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

502809

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

504006

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.458

High

512222

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

512782

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

514418

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

554988

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

556975

UNG
Uracil-DNA glycosylase

1

0

High-throughput

0.458

High

558544

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

572498

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.458

High

572500

TAL1
Transaldolase

1

0

High-throughput

0.458

High

572503

THRC
Threonine synthase

1

0

High-throughput

0.458

High

572508

PGTB1
Geranylgeranyl transferase type-1 subunit beta

1

0

High-throughput

0.458

High

572509

IRA2
Inhibitory regulator protein IRA2

1

0

Small-scale

0.458

High

572515

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

572517

TKT1
Transketolase 1

1

0

High-throughput

0.458

High

572524

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

572527

GID7
GID complex subunit 7

1

0

High-throughput

0.458

High

572528

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

572530

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

572533

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

572535

DHOM
Homoserine dehydrogenase

1

0

High-throughput

0.458

High

572536

EF2
Elongation factor 2

1

0

High-throughput

0.458

High

572539

EF1B
Elongation factor 1-beta

1

0

High-throughput

0.458

High

572540

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.458

High

572546

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

572548

YPT7
Ypt/Rab-type GTPase YPT7

1

0

Small-scale

0.458

High

572549

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

572552

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

572554

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.458

High

572555

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

572556

YPT52
GTP-binding protein YPT52

1

0

High-throughput

0.458

High

572560

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.458

High

572564

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.458

High

572566

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.458

High

572567

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

572570

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

572571

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

High-throughput

0.458

High

572574

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

572575

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

572579

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.458

High

572581

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

572588

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.458

High

572589

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

572591

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.458

High

572596

MMF1
Protein MMF1, mitochondrial

1

0

High-throughput

0.458

High

572599

MLP2
Protein MLP2

1

0

High-throughput

0.458

High

572600

TM108
Protein TMA108

1

0

High-throughput

0.458

High

572602

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.458

High

572605

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.458

High

572606

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

0

High-throughput

0.458

High

572607

MMM1
Maintenance of mitochondrial morphology protein 1

1

0

High-throughput

0.458

High

572609

SET4
SET domain-containing protein 4

1

0

Small-scale

0.458

High

572614

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

572616

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

572621

VID30
GID complex subunit 1

1

0

High-throughput

0.458

High

572625

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

572632

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

572636

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

572640

COFI
Cofilin

1

0

High-throughput

0.458

High

572641

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.458

High

572650

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.458

High

572655

ZEO1
Protein ZEO1

1

0

High-throughput

0.458

High

572658

SGO1
Shugoshin

1

0

High-throughput

0.458

High

572659

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

572660

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

572663

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

572562

AP3M
AP-3 complex subunit mu

1

1

High-throughput

0.457

High

572569

ARPC1
Actin-related protein 2/3 complex subunit 1

1

1

High-throughput

0.457

High

481455

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.445

High

572502

HSP26
Heat shock protein 26

1

1

High-throughput

0.445

High

572531

KCC1
Calcium/calmodulin-dependent protein kinase I

1

1

High-throughput

0.445

High

572534

PUS3
tRNA pseudouridine(38/39) synthase

1

1

High-throughput

0.445

High

572542

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

572585

XDJ1
DnaJ protein homolog XDJ1

1

2

High-throughput

0.445

High

572592

HSP7E
Heat shock protein SSC3, mitochondrial

1

3

High-throughput

0.445

High

572668

HSP42
Heat shock protein 42

1

1

High-throughput

0.445

High

506384

YK104
Putative uncharacterized protein YKR104W

1

1

High-throughput

0.439

High

572646

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.437

High

572671

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

572673

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.437

High

572504

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

572529

BUB2
Mitotic check point protein BUB2

1

0

High-throughput

0.426

High

572545

GLRX4
Monothiol glutaredoxin-4

1

0

High-throughput

0.426

High

572563

SEA4
SEH-associated protein 4

1

0

High-throughput

0.426

High

572568

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.426

High

572578

TVP23
Golgi apparatus membrane protein TVP23

1

0

High-throughput

0.426

High

572593

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.426

High

572598

ATM1
Iron-sulfur clusters transporter ATM1, mitochondrial

1

0

High-throughput

0.426

High

572612

LSB3
LAS seventeen-binding protein 3

1

0

High-throughput

0.426

High

572618

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.426

High

572624

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

1

0

High-throughput

0.426

High

572630

FMP41
Oxaloacetate tautomerase FMP41, mitochondrial

1

0

High-throughput

0.426

High

572637

ADA2
SAGA complex subunit ADA2

1

0

High-throughput

0.426

High

572664

TFB4
General transcription and DNA repair factor IIH subunit TFB4

1

0

Small-scale

0.426

High

572666

NCE2
Non-classical export protein 2

1

0

High-throughput

0.426

High

572674

FOLD
Dihydrofolate synthetase

1

0

High-throughput

0.426

High

572603

DSN1
Kinetochore-associated protein DSN1

3

0

High-throughput

0.330

High

572656

MED7
Mediator of RNA polymerase II transcription subunit 7

2

0

High-throughput

0.307

High

572634

SLG1
Protein SLG1

1

0

Small-scale

0.288

High

572587

YCFI
Metal resistance protein YCF1

1

0

High-throughput

0.282

High

572514

NUP1
Nucleoporin NUP1

1

0

High-throughput

0.279

Low

572559

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.279

Low

572561

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

0

High-throughput

0.279

Low

572576

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.279

Low

572644

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

0

High-throughput

0.279

Low

572649

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.279

Low

572675

SUS1
SAGA complex subunit SUS1

1

0

High-throughput

0.279

Low

572594

SHO1
High osmolarity signaling protein SHO1

1

0

Small-scale

0.269

Low

458997

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.261

Low

572512

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.261

Low

572519

VAN1
Mannan polymerase I complex VAN1 subunit

1

0

High-throughput

0.261

Low

572522

CDC10
Cell division control protein 10

1

0

High-throughput

0.261

Low

572525

DMC1
Meiotic recombination protein DMC1

1

0

High-throughput

0.261

Low

572537

CDC3
Cell division control protein 3

1

0

High-throughput

0.261

Low

572547

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.261

Low

572558

SWD2
COMPASS component SWD2

1

0

High-throughput

0.261

Low

572580

TEM1
Protein TEM1

1

0

High-throughput

0.261

Low

572582

DUN1
DNA damage response protein kinase DUN1

1

0

High-throughput

0.261

Low

572648

ERB1
Ribosome biogenesis protein ERB1

1

0

High-throughput

0.261

Low

572669

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.261

Low

572557

MID2
Cell wall integrity sensor MID2

1

0

Small-scale

0.251

Low

572638

ULP1
Ubiquitin-like-specific protease 1

1

0

High-throughput

0.251

Low

572507

PDI
Protein disulfide-isomerase

1

0

High-throughput

0.249

Low

572518

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

572532

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

572551

IXR1
Intrastrand cross-link recognition protein

1

0

Small-scale

0.249

Low

572572

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.249

Low

572577

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

572604

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.249

Low

572615

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

572617

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

572622

ERV14
ER-derived vesicles protein ERV14

1

0

High-throughput

0.249

Low

572626

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

572633

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.249

Low

572643

ESC1
Silent chromatin protein ESC1

1

0

High-throughput

0.249

Low

572647

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

572651

PEX30
Peroxisomal membrane protein PEX30

1

0

Small-scale

0.249

Low

572652

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

572661

TCO89
Target of rapamycin complex 1 subunit TCO89

1

0

High-throughput

0.249

Low

572662

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

572667

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.249

Low

572573

NPR3
Nitrogen permease regulator 3

1

0

High-throughput

0.232

Low

572584

TCPD
T-complex protein 1 subunit delta

1

0

High-throughput

0.232

Low

572590

NPR2
Nitrogen permease regulator 2

1

0

High-throughput

0.232

Low

572597

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.232

Low

572601

ICE2
Protein ICE2

1

0

High-throughput

0.232

Low

572610

EMP47
Protein EMP47

1

0

High-throughput

0.232

Low

572619

SPT20
SAGA complex subunit SPT20

1

0

High-throughput

0.232

Low

572665

HFI1
SAGA complex subunit HFI1

1

0

High-throughput

0.232

Low

572672

PEX11
Peroxisomal membrane protein PMP27

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025