HitPredict

Interactor 1: S10A6 (P06703)
Protein S100-A6 (Calcyclin) (Growth factor-inducible protein 2A9) (MLN 4) (Prolactin receptor-associated protein) (PRA) (S100 calcium-binding protein A6)
Gene: S100A6

Interactor 2: TRPM4 (Q8TD43)
Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4)
Gene: TRPM4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	31837246
Identification Methods	fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 90 Hs			1 1214
+	Hs
		615221 S10A1_HUMAN (1-88): 9.49e-34: 112: 43.33		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		642972 S10A4_HUMAN (1-90): 7.66e-33: 111: 48.91		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		685179 S10AB_HUMAN (2-88): 5.61e-33: 111: 30.34		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		639026 S100P_HUMAN (3-89): 2.35e-32: 109: 33.71		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		661361 S10A2_HUMAN (1-90): 1.38e-31: 107: 45.65		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		707382 S10A3_HUMAN (1-89): 4.44e-30: 104: 45.06		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		416480 S10A9_HUMAN (3-89): 8.47e-30: 103: 31.11		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		893818 S10AA_HUMAN (1-88): 2.14e-29: 102: 26.67		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		380818 S100B_HUMAN (3-89): 1.01e-28: 100: 39.33		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		396768 S10A8_HUMAN (1-89): 1.67e-27: 97.2: 25.84		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		707352 S10A5_HUMAN (1-88): 1.41e-25: 92.2: 51.14		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		1254558 S10AE_HUMAN (3-82): 4.51e-22: 83.7: 26.25		TRPM4_HUMAN (1-1214): 0: 1243: 100.00