HitPredict

Interactor 1: TPM3 (P06753)
Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5)
Gene: TPM3

Interactor 2: CC146 (Q8IYE0)
Coiled-coil domain-containing protein 146
Gene: CCDC146

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	25416956
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005856 - cytoskeleton
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 285 Hs			1 955
+	Hs
		1138391 Q5VU62_HUMAN (128-285): 1.66e-39: 137: 100.00		CC146_HUMAN (1-955): 2.74e-59: 221: 100.00
+	Hs
		418895 TPM3_HUMAN (1-285): 3.63e-44: 153: 100.00		MYH9_HUMAN (129-949): 1.25e-44: 178: 12.09
+	Hs
		451201 TPM1_HUMAN (2-285): 2.54e-44: 153: 91.20		MYH9_HUMAN (129-949): 1.25e-44: 178: 12.09
+	Hs
		434354 TPM2_HUMAN (2-285): 1.42e-39: 141: 86.27		MYH9_HUMAN (129-949): 1.25e-44: 178: 12.09
+	Hs
		724765 TPM4_HUMAN (43-285): 1.76e-33: 124: 69.96		MYH9_HUMAN (129-949): 1.25e-44: 178: 12.09
+	Dm
		419108 TPM1_DROME (2-282): 8.67e-51: 171: 45.97		MYSN_DROME (377-954): 2.2e-24: 112: 10.02
+	Dm
		404216 TPM2_DROME (2-284): 6.48e-36: 131: 47.70		MYSA_DROME (150-946): 3.46e-34: 144: 11.87
+	Mm
		101558 LAMA1_MOUSE (4-280): 3.27e-51: 182: 14.84		F8VQJ3_MOUSE (63-417): 5.21e-10: 65.7: 11.81
+	Hs
		148289 TPM3_HUMAN (1-285): 3.63e-44: 153: 100.00		CTRO_HUMAN (278-871): 2.3e-17: 90.1: 12.69
+	Hs
		110796 H7BYY1_HUMAN (2-228): 1.39e-10: 62.2: 21.37		MYH9_HUMAN (129-949): 1.25e-44: 178: 12.09
+	Hs
		419011 TPM3_HUMAN (1-285): 3.63e-44: 153: 100.00		MY18A_HUMAN (362-872): 3.44e-09: 63.4: 13.67
+	Hs
		451293 TPM1_HUMAN (2-285): 2.54e-44: 153: 91.20		MY18A_HUMAN (362-872): 3.44e-09: 63.4: 13.67
+	Hs
		148661 TPM4_HUMAN (43-285): 1.76e-33: 124: 69.96		CTRO_HUMAN (278-871): 2.3e-17: 90.1: 12.69
+	Hs
		434415 TPM2_HUMAN (2-285): 1.42e-39: 141: 86.27		MY18A_HUMAN (362-872): 3.44e-09: 63.4: 13.67
+	Hs
		932031 TPM4_HUMAN (43-285): 1.76e-33: 124: 69.96		MY18A_HUMAN (362-872): 3.44e-09: 63.4: 13.67
+	Hs
		1146002 MRCKB_HUMAN (12-285): 1.02e-11: 67.2: 14.92		CP135_HUMAN (145-911): 1.3e-17: 90.4: 11.89
+	Mm
		358674 LAMB1_MOUSE (3-211): 2.99e-16: 80.8: 19.05		LAMC1_MOUSE (63-417): 2.62e-10: 66.8: 11.81
+	Hs
		1268126 MRCKB_HUMAN (12-285): 1.02e-11: 67.2: 14.92		MY18A_HUMAN (362-872): 3.44e-09: 63.4: 13.67
+	Hs
		110802 H7BYY1_HUMAN (2-228): 1.39e-10: 62.2: 21.37		MY18A_HUMAN (362-872): 3.44e-09: 63.4: 13.67