HitPredict

Interactor 1: RAB3B (P20337)
Ras-related protein Rab-3B
Gene: RAB3B

Interactor 2: SYTL4 (Q96C24)
Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin)
Gene: SYTL4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	26553929, 34079125
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FYVE_2~Ras
Common GO terms	GO:0005768 - endosome GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 219 Hs			1 671
+	Mm
		877205 RAB8A_MOUSE (15-219): 8.41e-101: 292: 47.32		SYTL4_MOUSE (1-671): 0: 564: 90.19
+	Hs
		894790 RAB8A_HUMAN (15-219): 2.07e-91: 268: 46.83		SYTL4_HUMAN (1-671): 0: 587: 100.00
+	Hs
		320135 RAB3D_HUMAN (1-219): 1.01e-84: 252: 75.80		SYTL4_HUMAN (1-671): 0: 587: 100.00
+	Hs
		591484 RAB3A_HUMAN (1-219): 1.23e-82: 246: 77.27		SYTL4_HUMAN (1-671): 0: 587: 100.00
+	Hs
		591638 RAB3B_HUMAN (1-219): 9.48e-85: 252: 100.00		SYTL5_HUMAN (2-669): 9.15e-161: 481: 38.17
+	Hs
		591482 RAB3A_HUMAN (1-219): 1.23e-82: 246: 77.27		SYTL5_HUMAN (2-669): 9.15e-161: 481: 38.17
+	Hs
		894765 RAB8A_HUMAN (15-219): 2.07e-91: 268: 46.83		SYTL1_HUMAN (110-665): 1.09e-83: 276: 29.62
+	Hs
		1134943 RAB1B_HUMAN (15-219): 1.44e-86: 255: 42.44		SYT6_HUMAN (224-660): 2.2e-85: 279: 21.56
+	Mm
		812770 RAB8A_MOUSE (15-219): 8.41e-101: 292: 47.32		RP3A_MOUSE (518-671): 6.38e-29: 124: 22.49
+	Hs
		894828 RAB8A_HUMAN (15-219): 2.07e-91: 268: 46.83		RP3A_HUMAN (518-671): 1.14e-28: 123: 23.08
+	Mm
		722679 RAB3D_MOUSE (1-219): 1.23e-87: 259: 76.71		RP3A_MOUSE (518-671): 6.38e-29: 124: 22.49
+	Hs
		591719 RAB3B_HUMAN (1-219): 9.48e-85: 252: 100.00		RP3A_HUMAN (518-671): 1.14e-28: 123: 23.08
+	Mm
		812777 RAB3B_MOUSE (1-219): 3.19e-84: 250: 97.26		RP3A_MOUSE (518-671): 6.38e-29: 124: 22.49
+	Mm
		812771 RAB3C_MOUSE (1-219): 1.78e-83: 249: 80.37		RP3A_MOUSE (518-671): 6.38e-29: 124: 22.49
+	Hs
		591501 RAB3A_HUMAN (1-219): 1.23e-82: 246: 77.27		RP3A_HUMAN (518-671): 1.14e-28: 123: 23.08
+	Rn
		812780 RAB3A_RAT (1-219): 1.15e-82: 246: 76.82		RP3A_RAT (518-671): 1.13e-28: 123: 22.49
+	Mm
		722691 RAB3D_MOUSE (1-219): 1.23e-87: 259: 76.71		RIMS1_MOUSE (108-637): 1.93e-18: 92.3: 13.94
+	Hs
		129082 RAB1A_HUMAN (12-219): 4.97e-88: 259: 42.31		SYT5_HUMAN (347-458): 3.13e-19: 92.2: 31.25
+	Mm
		1307912 RAB3B_MOUSE (1-219): 3.19e-84: 250: 97.26		RIMS1_MOUSE (108-637): 1.93e-18: 92.3: 13.94
+	Mm
		919021 RAB3C_MOUSE (1-219): 1.78e-83: 249: 80.37		RIMS1_MOUSE (108-637): 1.93e-18: 92.3: 13.94