HitPredict

Interactor 1: GDN (P07093)
Glia-derived nexin (GDN) (Peptidase inhibitor 7) (PI-7) (Protease nexin 1) (PN-1) (Protease nexin I) (Serpin E2)
Gene: SERPINE2

Interactor 2: KLK2 (P20151)
Kallikrein-2 (EC 3.4.21.35) (Glandular kallikrein-1) (hGK-1) (Tissue kallikrein-2)
Gene: KLK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 398 Hs			1 261
+	Hs
		421277 GDN_HUMAN (1-398): 6.75e-164: 467: 100.00		KLK13_HUMAN (1-259): 7.75e-108: 314: 44.65
+	Mm
		430527 A1AT1_MOUSE (5-398): 5.41e-151: 435: 25.12		Q9Z1R9_MOUSE (2-260): 8.17e-118: 338: 41.70
+	Hs
		589593 SPB6_HUMAN (27-398): 1.22e-144: 417: 29.92		KLK2_HUMAN (1-261): 7.7e-123: 352: 100.00
+	Hs
		344274 AACT_HUMAN (17-398): 7.52e-140: 406: 26.53		KLK2_HUMAN (1-261): 7.7e-123: 352: 100.00
+	Hs
		344148 A1AT_HUMAN (5-398): 4.99e-143: 415: 23.04		KLK1_HUMAN (1-260): 3.01e-118: 340: 65.90
+	Hs
		428671 SPB8_HUMAN (27-398): 2.31e-144: 416: 30.16		TRY1_HUMAN (2-260): 5.4e-118: 339: 42.09
+	Hs
		344149 A1AT_HUMAN (5-398): 4.99e-143: 415: 23.04		KLK3_HUMAN (1-261): 1.45e-115: 333: 77.01
+	Hs
		344097 ANT3_HUMAN (26-398): 3.33e-139: 406: 30.05		KLK1_HUMAN (1-260): 3.01e-118: 340: 65.90
+	Hs
		397636 IPSP_HUMAN (33-398): 3.66e-135: 394: 26.20		KLK2_HUMAN (1-261): 7.7e-123: 352: 100.00
+	Hs
		719387 SPB6_HUMAN (27-398): 1.22e-144: 417: 29.92		KLK13_HUMAN (1-259): 7.75e-108: 314: 44.65
+	Hs
		397629 IPSP_HUMAN (33-398): 3.66e-135: 394: 26.20		KLK3_HUMAN (1-261): 1.45e-115: 333: 77.01
+	Hs
		344349 AACT_HUMAN (17-398): 7.52e-140: 406: 26.53		KLK13_HUMAN (1-259): 7.75e-108: 314: 44.65
+	Mm
		1141519 SPB6_MOUSE (27-398): 2.3e-140: 406: 27.94		KLK8_MOUSE (4-257): 1.14e-104: 305: 44.88
+	Hs
		344172 A1AT_HUMAN (5-398): 4.99e-143: 415: 23.04		CTRL_HUMAN (12-260): 5.28e-92: 273: 34.62
+	Hs
		371463 IPSP_HUMAN (33-398): 3.66e-135: 394: 26.20		KLKB1_HUMAN (15-259): 2.13e-92: 286: 33.85
+	Hs
		344256 A1AT_HUMAN (5-398): 4.99e-143: 415: 23.04		KLK4_HUMAN (23-260): 4.68e-52: 171: 40.17
+	Hs
		198328 A1AT_HUMAN (5-398): 4.99e-143: 415: 23.04		KLK10_HUMAN (28-260): 7.17e-45: 154: 39.49
+	Hs
		198417 SPB10_HUMAN (26-398): 3.11e-143: 414: 28.18		KLK10_HUMAN (28-260): 7.17e-45: 154: 39.49
+	Hs
		341268 ANT3_HUMAN (26-398): 3.33e-139: 406: 30.05		FA9_HUMAN (23-255): 1.34e-37: 139: 35.63
+	Hs
		344100 ANT3_HUMAN (26-398): 3.33e-139: 406: 30.05		GRAA_HUMAN (24-257): 1.25e-37: 134: 37.04