Protein: CRY1
Cryptochrome-1

Gene: CRY1
Organism: Homo sapiens
Interactions: 225
UniProt ID: Q16526

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0003690 - double-stranded DNA binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

165986

PER2
Period circadian protein homolog 2

9

20

Small-scale

0.968

High

182345

PER1
Period circadian protein homolog 1

6

20

Small-scale

0.942

High

1082120

CRY2
Cryptochrome-2

4

7

Small-scale

0.892

High

1082163

FBXL3
F-box/LRR-repeat protein 3

7

7

Small-scale

0.747

High

830368

KC1E
Casein kinase I isoform epsilon

6

8

High-throughput

0.739

High

1041007

CUL1
Cullin-1

5

2

Small-scale

0.718

High

126131

BMAL1
Basic helix-loop-helix ARNT-like protein 1

4

18

Small-scale

0.688

High

822272

KC1D
Casein kinase I isoform delta

3

8

High-throughput

0.675

High

928927

SKP1
S-phase kinase-associated protein 1

3

1

Small-scale

0.667

High

1070065

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

3

1

High-throughput

0.667

High

1082133

TEKT4
Tektin-4

3

1

High-throughput

0.667

High

1082114

CRY1
Cryptochrome-1

1

7

Small-scale

0.647

High

181525

CLOCK
Circadian locomoter output cycles protein kaput

3

15

Small-scale

0.629

High

283192

RGS20
Regulator of G-protein signaling 20

2

1

High-throughput

0.611

High

1082140

AP2M1
AP-2 complex subunit mu

3

1

High-throughput

0.609

High

153681

ANM5
Protein arginine N-methyltransferase 5

2

2

Small-scale

0.594

High

170078

PLS1
Phospholipid scramblase 1

2

0

High-throughput

0.587

High

672427

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

2

4

High-throughput

0.586

High

931656

CSK2B
Casein kinase II subunit beta

2

3

Small-scale

0.586

High

162789

XPO1
Exportin-1

2

4

High-throughput

0.584

High

397401

ADT2
ADP/ATP translocase 2

2

1

Small-scale

0.571

High

502149

BIP
Endoplasmic reticulum chaperone BiP

2

3

Small-scale

0.571

High

613472

SFPQ
Splicing factor, proline- and glutamine-rich

2

4

Small-scale

0.571

High

616339

RS3
Small ribosomal subunit protein uS3

2

2

Small-scale

0.571

High

643519

PTBP1
Polypyrimidine tract-binding protein 1

2

4

Small-scale

0.571

High

681464

DNJA1
DnaJ homolog subfamily A member 1

2

1

Small-scale

0.571

High

852072

ROA3
Heterogeneous nuclear ribonucleoprotein A3

2

5

Small-scale

0.571

High

910443

RS14
Small ribosomal subunit protein uS11

2

1

Small-scale

0.571

High

962112

HNRPU
Heterogeneous nuclear ribonucleoprotein U

2

1

Small-scale

0.571

High

1019769

ILF3
Interleukin enhancer-binding factor 3

2

2

Small-scale

0.571

High

1043012

CUL4A
Cullin-4A

2

2

Small-scale

0.571

High

271101

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

4

Small-scale

0.561

High

934195

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.561

High

1082138

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.561

High

1016190

FOXO1
Forkhead box protein O1

2

0

Small-scale

0.559

High

418316

NPM
Nucleophosmin

2

0

Small-scale

0.547

High

990076

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

2

0

Small-scale

0.547

High

1060763

IMB1
Importin subunit beta-1

2

0

Small-scale

0.547

High

1020683

TRAF2
TNF receptor-associated factor 2

1

2

High-throughput

0.541

High

235880

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

3

High-throughput

0.536

High

803555

BAG6
Large proline-rich protein BAG6

1

1

High-throughput

0.536

High

1082119

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

5

High-throughput

0.536

High

1082134

BMAL2
Basic helix-loop-helix ARNT-like protein 2

1

20

High-throughput

0.536

High

1082165

BAIP2
BAR/IMD domain-containing adapter protein 2

1

1

High-throughput

0.536

High

1027608

CBLB
E3 ubiquitin-protein ligase CBL-B

1

0

High-throughput

0.518

High

1082146

MDFI
MyoD family inhibitor

1

0

High-throughput

0.518

High

556875

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.513

High

1082141

KI20B
Kinesin-like protein KIF20B

1

0

High-throughput

0.513

High

1082142

TGS1
Trimethylguanosine synthase

1

0

High-throughput

0.513

High

858627

PPP5
Serine/threonine-protein phosphatase 5

1

7

Small-scale

0.500

High

1082148

KR412
Keratin-associated protein 4-12

1

6

High-throughput

0.494

High

1058670

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

3

High-throughput

0.481

High

1061341

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

2

High-throughput

0.481

High

1082116

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

3

High-throughput

0.481

High

1082145

NPAS2
Neuronal PAS domain-containing protein 2

1

16

High-throughput

0.481

High

1082153

BHE41
Class E basic helix-loop-helix protein 41

1

10

High-throughput

0.481

High

1082170

ARI1
E3 ubiquitin-protein ligase ARIH1

1

0

High-throughput

0.480

High

121775

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

2

High-throughput

0.479

High

198640

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.479

High

270639

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

1

High-throughput

0.479

High

428233

TBB5
Tubulin beta chain

1

1

High-throughput

0.479

High

430966

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

2

High-throughput

0.479

High

475041

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

495535

THIO
Thioredoxin

1

1

High-throughput

0.479

High

514013

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

1

High-throughput

0.479

High

516537

PABP1
Polyadenylate-binding protein 1

1

4

High-throughput

0.479

High

518671

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.479

High

524938

XRCC5
X-ray repair cross-complementing protein 5

1

1

High-throughput

0.479

High

531165

EF2
Elongation factor 2

1

3

High-throughput

0.479

High

537917

KPYM
Pyruvate kinase PKM

1

1

High-throughput

0.479

High

541022

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

6

High-throughput

0.479

High

541370

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

598138

FLNA
Filamin-A

1

1

High-throughput

0.479

High

606427

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.479

High

627274

MCM3
DNA replication licensing factor MCM3

1

6

High-throughput

0.479

High

636939

ATPA
ATP synthase subunit alpha, mitochondrial

1

3

High-throughput

0.479

High

646929

1433T
14-3-3 protein theta

1

6

High-throughput

0.479

High

649528

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

672139

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

4

High-throughput

0.479

High

677981

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

1

High-throughput

0.479

High

682827

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

7

High-throughput

0.479

High

683380

1433B
14-3-3 protein beta/alpha

1

6

High-throughput

0.479

High

708453

MCM4
DNA replication licensing factor MCM4

1

5

High-throughput

0.479

High

708928

MCM7
DNA replication licensing factor MCM7

1

5

High-throughput

0.479

High

770851

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.479

High

782912

GARS
Glycine--tRNA ligase

1

1

High-throughput

0.479

High

783045

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

789808

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

793977

MATR3
Matrin-3

1

3

High-throughput

0.479

High

798676

PRS6B
26S proteasome regulatory subunit 6B

1

5

High-throughput

0.479

High

825833

NASP
Nuclear autoantigenic sperm protein

1

1

High-throughput

0.479

High

825963

FAS
Fatty acid synthase

1

1

High-throughput

0.479

High

842883

TCPQ
T-complex protein 1 subunit theta

1

5

High-throughput

0.479

High

850067

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

6

High-throughput

0.479

High

855075

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

7

High-throughput

0.479

High

878666

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

7

High-throughput

0.479

High

880120

SYMC
Methionine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

892816

IF4A1
Eukaryotic initiation factor 4A-I

1

6

High-throughput

0.479

High

903959

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

4

High-throughput

0.479

High

906841

PRS4
26S proteasome regulatory subunit 4

1

5

High-throughput

0.479

High

907045

PRS8
26S proteasome regulatory subunit 8

1

6

High-throughput

0.479

High

909607

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

913278

PRS10
26S proteasome regulatory subunit 10B

1

6

High-throughput

0.479

High

915201

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

3

High-throughput

0.479

High

924013

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

1

High-throughput

0.479

High

927087

1433Z
14-3-3 protein zeta/delta

1

6

High-throughput

0.479

High

932723

EF1A1
Elongation factor 1-alpha 1

1

3

High-throughput

0.479

High

944264

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

High-throughput

0.479

High

982051

1433F
14-3-3 protein eta

1

6

High-throughput

0.479

High

989306

PRDX1
Peroxiredoxin-1

1

2

High-throughput

0.479

High

991780

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

1

High-throughput

0.479

High

1026694

PRDX4
Peroxiredoxin-4

1

2

High-throughput

0.479

High

1029472

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

1031346

PABP4
Polyadenylate-binding protein 4

1

4

High-throughput

0.479

High

1064341

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

1071883

PCBP1
Poly(rC)-binding protein 1

1

4

High-throughput

0.479

High

1082125

DET1
DET1 homolog

1

1

Small-scale

0.479

High

1082127

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

1082137

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

3

High-throughput

0.479

High

1082149

MEP50
Methylosome protein WDR77

1

1

High-throughput

0.479

High

1082156

PABP3
Polyadenylate-binding protein 3

1

4

High-throughput

0.479

High

1082158

MLXPL
Carbohydrate-responsive element-binding protein

1

1

Small-scale

0.479

High

1082162

FXL21
Putative F-box/LRR-repeat protein 21

1

7

Small-scale

0.479

High

1082166

RUVB2
RuvB-like 2

1

3

High-throughput

0.479

High

1082167

RUVB1
RuvB-like 1

1

3

High-throughput

0.479

High

1082168

FBW1A
F-box/WD repeat-containing protein 1A

1

4

Small-scale

0.479

High

912647

SMD3
Small nuclear ribonucleoprotein Sm D3

1

0

High-throughput

0.460

High

266718

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.458

High

531371

K1C10
Keratin, type I cytoskeletal 10

1

0

High-throughput

0.458

High

607078

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

0

High-throughput

0.458

High

729100

K22E
Keratin, type II cytoskeletal 2 epidermal

1

0

High-throughput

0.458

High

782558

HNF4A
Hepatocyte nuclear factor 4-alpha

1

0

Small-scale

0.458

High

825003

AL9A1
4-trimethylaminobutyraldehyde dehydrogenase

1

0

High-throughput

0.458

High

867711

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

1031205

SKP2
S-phase kinase-associated protein 2

1

0

Small-scale

0.458

High

1082118

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

134062

DDX3X
ATP-dependent RNA helicase DDX3X

1

6

Small-scale

0.445

High

241537

H2B1K
Histone H2B type 1-K

1

4

Small-scale

0.445

High

272157

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

5

Small-scale

0.445

High

382006

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

Small-scale

0.445

High

470398

H2A1
Histone H2A type 1

1

1

Small-scale

0.445

High

499775

CH60
60 kDa heat shock protein, mitochondrial

1

3

Small-scale

0.445

High

550796

RS2
Small ribosomal subunit protein uS5

1

1

Small-scale

0.445

High

571473

DDX5
Probable ATP-dependent RNA helicase DDX5

1

5

Small-scale

0.445

High

582313

NUCL
Nucleolin

1

4

Small-scale

0.445

High

595246

LMNB1
Lamin-B1

1

3

Small-scale

0.445

High

623125

EF1B
Elongation factor 1-beta

1

1

Small-scale

0.445

High

713984

HS71L
Heat shock 70 kDa protein 1-like

1

1

Small-scale

0.445

High

751646

GRP75
Stress-70 protein, mitochondrial

1

5

Small-scale

0.445

High

853307

IMA1
Importin subunit alpha-1

1

4

Small-scale

0.445

High

905926

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

2

Small-scale

0.445

High

994185

DHX9
ATP-dependent RNA helicase A

1

2

Small-scale

0.445

High

1019513

ILF2
Interleukin enhancer-binding factor 2

1

1

Small-scale

0.445

High

1025763

TADBP
TAR DNA-binding protein 43

1

5

Small-scale

0.445

High

1082115

DDB1
DNA damage-binding protein 1

1

2

Small-scale

0.445

High

1082117

H2B2E
Histone H2B type 2-E

1

4

Small-scale

0.445

High

1082136

DDX17
Probable ATP-dependent RNA helicase DDX17

1

5

Small-scale

0.445

High

1082139

H2B1A
Histone H2B type 1-A

1

3

Small-scale

0.445

High

1082143

DNJC7
DnaJ homolog subfamily C member 7

1

5

Small-scale

0.445

High

1082160

BCLF1
Bcl-2-associated transcription factor 1

1

2

Small-scale

0.445

High

660511

GRN
Progranulin

1

1

High-throughput

0.439

High

1082161

DEC1
Deleted in esophageal cancer 1

1

1

High-throughput

0.439

High

573278

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.437

High

843213

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.437

High

862400

ACLY
ATP-citrate synthase

1

1

High-throughput

0.437

High

1051869

IF4A2
Eukaryotic initiation factor 4A-II

1

9

High-throughput

0.437

High

1082122

SCYL2
SCY1-like protein 2

1

1

High-throughput

0.437

High

169855

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

Small-scale

0.426

High

171401

SMAD9
Mothers against decapentaplegic homolog 9

1

0

Small-scale

0.426

High

172746

ZN185
Zinc finger protein 185

1

0

Small-scale

0.426

High

445419

RSSA
Small ribosomal subunit protein uS2

1

0

Small-scale

0.426

High

575065

RL7
Large ribosomal subunit protein uL30

1

0

Small-scale

0.426

High

736493

RL4
Large ribosomal subunit protein uL4

1

0

Small-scale

0.426

High

781903

PERI
Peripherin

1

0

Small-scale

0.426

High

807166

RS5
Small ribosomal subunit protein uS7

1

0

Small-scale

0.426

High

886388

NAL11
NACHT, LRR and PYD domains-containing protein 11

1

0

Small-scale

0.426

High

905646

RS7
Small ribosomal subunit protein eS7

1

0

Small-scale

0.426

High

910852

RS18
Small ribosomal subunit protein uS13

1

0

Small-scale

0.426

High

913550

RL7A
Large ribosomal subunit protein eL8

1

0

Small-scale

0.426

High

916212

RL23A
Large ribosomal subunit protein uL23

1

0

Small-scale

0.426

High

917342

H4
Histone H4

1

0

Small-scale

0.426

High

931181

YBOX1
Y-box-binding protein 1

1

0

Small-scale

0.426

High

951575

RL19
Large ribosomal subunit protein eL19

1

0

Small-scale

0.426

High

978175

ARI5A
AT-rich interactive domain-containing protein 5A

1

0

Small-scale

0.426

High

989812

RL18
Large ribosomal subunit protein eL18

1

0

Small-scale

0.426

High

1082124

BCOR
BCL-6 corepressor

1

0

Small-scale

0.426

High

1082135

TITIN
Titin

1

0

Small-scale

0.426

High

1082144

PHB2
Prohibitin-2

1

0

Small-scale

0.426

High

1082150

MBB1A
Myb-binding protein 1A

1

0

Small-scale

0.426

High

1082152

HELZ2
3'-5' exoribonuclease HELZ2

1

0

Small-scale

0.426

High

1082154

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

Small-scale

0.426

High

1082155

PININ
Pinin

1

0

Small-scale

0.426

High

1082159

AATF
Protein AATF

1

0

Small-scale

0.426

High

72189

B3KSW4
Regulator of G protein signaling 20

1

1

High-throughput

0.407

High

618632

IF4B
Eukaryotic translation initiation factor 4B

1

3

Small-scale

0.407

High

781551

CETN2
Centrin-2

1

2

Small-scale

0.407

High

1052526

RCN2
Reticulocalbin-2

1

2

Small-scale

0.407

High

1082123

CC171
Coiled-coil domain-containing protein 171

1

1

Small-scale

0.407

High

1082128

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

Small-scale

0.407

High

1082157

YTDC2
3'-5' RNA helicase YTHDC2

1

2

Small-scale

0.407

High

854184

JAK3
Tyrosine-protein kinase JAK3

1

0

High-throughput

0.279

Low

1082129

RAB43
Ras-related protein Rab-43

1

0

High-throughput

0.279

Low

1082131

NEDD1
Protein NEDD1

1

0

High-throughput

0.279

Low

1082147

RETNB
Resistin-like beta

1

0

High-throughput

0.279

Low

1082130

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

0

High-throughput

0.251

Low

836648

GUAA
GMP synthase [glutamine-hydrolyzing]

1

0

High-throughput

0.249

Low

986452

PUR1
Amidophosphoribosyltransferase

1

0

High-throughput

0.249

Low

1082151

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.249

Low

367

KVD30
Immunoglobulin kappa variable 2D-30

1

0

Small-scale

0.232

Low

47709

S12A8
Solute carrier family 12 member 8

1

0

Small-scale

0.232

Low

60161

XIRP2
Xin actin-binding repeat-containing protein 2

1

0

Small-scale

0.232

Low

151805

IRS4
Insulin receptor substrate 4

1

0

Small-scale

0.232

Low

326990

ABHGA
Phosphatidylserine lipase ABHD16A

1

0

Small-scale

0.232

Low

802111

NOP2
Probable 28S rRNA

1

0

Small-scale

0.232

Low

813043

CAZA2
F-actin-capping protein subunit alpha-2

1

0

Small-scale

0.232

Low

981053

KPCT
Protein kinase C theta type

1

0

Small-scale

0.232

Low

1034691

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

0

Small-scale

0.232

Low

1045426

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

0

Small-scale

0.232

Low

1047555

CNCG
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

1

0

Small-scale

0.232

Low

1082121

IFT1B
Interferon-induced protein with tetratricopeptide repeats 1B

1

0

Small-scale

0.232

Low

1082126

RAB44
Ras-related protein Rab-44

1

0

Small-scale

0.232

Low

1082132

SHRM3
Protein Shroom3

1

0

Small-scale

0.232

Low

1082164

CFA92
Uncharacterized protein CFAP92

1

0

Small-scale

0.232

Low

1082169

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024