Protein: CRY1
Cryptochrome-1

Gene: CRY1
Organism: Homo sapiens
Interactions: 227
UniProt ID: Q16526

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0003690 - double-stranded DNA binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

176202

PER2
Period circadian protein homolog 2

9

20

Small-scale

0.968

High

193779

PER1
Period circadian protein homolog 1

6

20

Small-scale

0.942

High

1157647

CRY2
Cryptochrome-2

4

7

Small-scale

0.892

High

1157692

FBXL3
F-box/LRR-repeat protein 3

7

7

Small-scale

0.747

High

885785

KC1E
Casein kinase I isoform epsilon

6

8

High-throughput

0.739

High

1112510

CUL1
Cullin-1

5

2

Small-scale

0.718

High

877124

KC1D
Casein kinase I isoform delta

4

8

High-throughput

0.697

High

992192

SKP1
S-phase kinase-associated protein 1

4

1

Small-scale

0.691

High

132727

BMAL1
Basic helix-loop-helix ARNT-like protein 1

4

18

Small-scale

0.688

High

1144763

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

3

1

High-throughput

0.667

High

1157662

TEKT4
Tektin-4

3

1

High-throughput

0.667

High

1157641

CRY1
Cryptochrome-1

1

7

Small-scale

0.647

High

192925

CLOCK
Circadian locomoter output cycles protein kaput

3

15

Small-scale

0.629

High

303134

RGS20
Regulator of G-protein signaling 20

2

1

High-throughput

0.611

High

1157669

AP2M1
AP-2 complex subunit mu

3

1

High-throughput

0.609

High

162582

ANM5
Protein arginine N-methyltransferase 5

2

2

Small-scale

0.594

High

180524

PLS1
Phospholipid scramblase 1

2

0

High-throughput

0.587

High

718126

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

2

4

High-throughput

0.586

High

995058

CSK2B
Casein kinase II subunit beta

2

3

Small-scale

0.586

High

172861

XPO1
Exportin-1

2

4

High-throughput

0.584

High

424914

ADT2
ADP/ATP translocase 2

2

1

Small-scale

0.571

High

535112

BIP
Endoplasmic reticulum chaperone BiP

2

3

Small-scale

0.571

High

655214

SFPQ
Splicing factor, proline- and glutamine-rich

2

4

Small-scale

0.571

High

658201

RS3
Small ribosomal subunit protein uS3

2

2

Small-scale

0.571

High

687426

PTBP1
Polypyrimidine tract-binding protein 1

2

4

Small-scale

0.571

High

727822

DNJA1
DnaJ homolog subfamily A member 1

2

1

Small-scale

0.571

High

909590

ROA3
Heterogeneous nuclear ribonucleoprotein A3

2

5

Small-scale

0.571

High

972427

RS14
Small ribosomal subunit protein uS11

2

1

Small-scale

0.571

High

1027485

HNRPU
Heterogeneous nuclear ribonucleoprotein U

2

1

Small-scale

0.571

High

1089685

ILF3
Interleukin enhancer-binding factor 3

2

2

Small-scale

0.571

High

1114847

CUL4A
Cullin-4A

2

2

Small-scale

0.571

High

288421

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

4

Small-scale

0.561

High

997741

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.561

High

1157667

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.561

High

1085564

FOXO1
Forkhead box protein O1

2

0

Small-scale

0.559

High

447064

NPM
Nucleophosmin

2

0

Small-scale

0.547

High

1058037

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

2

0

Small-scale

0.547

High

1134214

IMB1
Importin subunit beta-1

2

0

Small-scale

0.547

High

1090666

TRAF2
TNF receptor-associated factor 2

1

2

High-throughput

0.541

High

250631

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

3

High-throughput

0.536

High

856710

BAG6
Large proline-rich protein BAG6

1

1

High-throughput

0.536

High

1157646

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

4

High-throughput

0.536

High

1157663

BMAL2
Basic helix-loop-helix ARNT-like protein 2

1

20

High-throughput

0.536

High

1157694

BAIP2
BAR/IMD domain-containing adapter protein 2

1

1

High-throughput

0.536

High

1097938

CBLB
E3 ubiquitin-protein ligase CBL-B

1

0

High-throughput

0.518

High

1157675

MDFI
MyoD family inhibitor

1

0

High-throughput

0.518

High

593117

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.513

High

1157660

NEDD1
Protein NEDD1

1

0

High-throughput

0.513

High

1157670

KI20B
Kinesin-like protein KIF20B

1

0

High-throughput

0.513

High

1157671

TGS1
Trimethylguanosine synthase

1

0

High-throughput

0.513

High

916661

PPP5
Serine/threonine-protein phosphatase 5

1

7

Small-scale

0.500

High

1157677

KR412
Keratin-associated protein 4-12

1

6

High-throughput

0.494

High

1131663

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

3

High-throughput

0.481

High

1134821

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

2

High-throughput

0.481

High

1157643

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

3

High-throughput

0.481

High

1157674

NPAS2
Neuronal PAS domain-containing protein 2

1

16

High-throughput

0.481

High

1157682

BHE41
Class E basic helix-loop-helix protein 41

1

10

High-throughput

0.481

High

1157699

ARI1
E3 ubiquitin-protein ligase ARIH1

1

0

High-throughput

0.480

High

127975

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

2

High-throughput

0.479

High

210960

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.479

High

287931

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

1

High-throughput

0.479

High

457469

TBB5
Tubulin beta chain

1

1

High-throughput

0.479

High

460544

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

2

High-throughput

0.479

High

507207

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

528262

THIO
Thioredoxin

1

1

High-throughput

0.479

High

547618

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

1

High-throughput

0.479

High

550305

PABP1
Polyadenylate-binding protein 1

1

4

High-throughput

0.479

High

552596

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.479

High

559368

XRCC5
X-ray repair cross-complementing protein 5

1

1

High-throughput

0.479

High

565918

EF2
Elongation factor 2

1

3

High-throughput

0.479

High

573117

KPYM
Pyruvate kinase PKM

1

1

High-throughput

0.479

High

576415

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

5

High-throughput

0.479

High

576776

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

637535

FLNA
Filamin-A

1

1

High-throughput

0.479

High

646851

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.479

High

669911

MCM3
DNA replication licensing factor MCM3

1

6

High-throughput

0.479

High

680370

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

3

High-throughput

0.479

High

691046

1433T
14-3-3 protein theta

1

6

High-throughput

0.479

High

693762

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

717827

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

4

High-throughput

0.479

High

724088

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

1

High-throughput

0.479

High

729286

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

7

High-throughput

0.479

High

729871

1433B
14-3-3 protein beta/alpha

1

6

High-throughput

0.479

High

755722

MCM4
DNA replication licensing factor MCM4

1

5

High-throughput

0.479

High

756217

MCM7
DNA replication licensing factor MCM7

1

5

High-throughput

0.479

High

821369

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.479

High

834319

GARS
Glycine--tRNA ligase

1

1

High-throughput

0.479

High

834458

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

841754

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

846318

MATR3
Matrin-3

1

3

High-throughput

0.479

High

851331

PRS6B
26S proteasome regulatory subunit 6B

1

5

High-throughput

0.479

High

881055

NASP
Nuclear autoantigenic sperm protein

1

1

High-throughput

0.479

High

881195

FAS
Fatty acid synthase

1

1

High-throughput

0.479

High

899054

TCPQ
T-complex protein 1 subunit theta

1

5

High-throughput

0.479

High

907449

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

4

High-throughput

0.479

High

912901

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

7

High-throughput

0.479

High

938729

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

7

High-throughput

0.479

High

940253

SYMC
Methionine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

953898

IF4A1
Eukaryotic initiation factor 4A-I

1

6

High-throughput

0.479

High

965698

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

4

High-throughput

0.479

High

968715

PRS4
26S proteasome regulatory subunit 4

1

5

High-throughput

0.479

High

968936

PRS8
26S proteasome regulatory subunit 8

1

6

High-throughput

0.479

High

971570

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

975412

PRS10
26S proteasome regulatory subunit 10B

1

6

High-throughput

0.479

High

977503

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

3

High-throughput

0.479

High

987047

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

1

High-throughput

0.479

High

990270

1433Z
14-3-3 protein zeta/delta

1

6

High-throughput

0.479

High

996178

EF1A1
Elongation factor 1-alpha 1

1

3

High-throughput

0.479

High

1008171

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

High-throughput

0.479

High

1049330

1433F
14-3-3 protein eta

1

6

High-throughput

0.479

High

1057163

PRDX1
Peroxiredoxin-1

1

2

High-throughput

0.479

High

1059852

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

1

High-throughput

0.479

High

1096973

PRDX4
Peroxiredoxin-4

1

2

High-throughput

0.479

High

1099942

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

1101973

PABP4
Polyadenylate-binding protein 4

1

4

High-throughput

0.479

High

1138249

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

1146683

PCBP1
Poly(rC)-binding protein 1

1

4

High-throughput

0.479

High

1157653

DET1
DET1 homolog

1

1

Small-scale

0.479

High

1157655

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

1157666

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

3

High-throughput

0.479

High

1157678

MEP50
Methylosome protein WDR77

1

1

High-throughput

0.479

High

1157685

PABP3
Polyadenylate-binding protein 3

1

4

High-throughput

0.479

High

1157687

MLXPL
Carbohydrate-responsive element-binding protein

1

1

Small-scale

0.479

High

1157691

FXL21
Putative F-box/LRR-repeat protein 21

1

7

Small-scale

0.479

High

1157695

RUVB2
RuvB-like 2

1

3

High-throughput

0.479

High

1157696

RUVB1
RuvB-like 1

1

3

High-throughput

0.479

High

1157697

FBW1A
F-box/WD repeat-containing protein 1A

1

4

Small-scale

0.479

High

974754

SMD3
Small nuclear ribonucleoprotein Sm D3

1

0

High-throughput

0.460

High

283867

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.458

High

566157

K1C10
Keratin, type I cytoskeletal 10

1

0

High-throughput

0.458

High

647563

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

0

High-throughput

0.458

High

777478

K22E
Keratin, type II cytoskeletal 2 epidermal

1

0

High-throughput

0.458

High

833956

HNF4A
Hepatocyte nuclear factor 4-alpha

1

0

Small-scale

0.458

High

880096

AL9A1
4-trimethylaminobutyraldehyde dehydrogenase

1

0

High-throughput

0.458

High

926479

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

1101823

SKP2
S-phase kinase-associated protein 2

1

0

Small-scale

0.458

High

1157645

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

1157680

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

141508

DDX3X
ATP-dependent RNA helicase DDX3X

1

6

Small-scale

0.445

High

256870

H2B1K
Histone H2B type 1-K

1

4

Small-scale

0.445

High

289559

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

8

Small-scale

0.445

High

408901

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

Small-scale

0.445

High

502369

H2A1
Histone H2A type 1

1

1

Small-scale

0.445

High

532612

CH60
60 kDa heat shock protein, mitochondrial

1

3

Small-scale

0.445

High

586718

RS2
Small ribosomal subunit protein uS5

1

1

Small-scale

0.445

High

608618

DDX5
Probable ATP-dependent RNA helicase DDX5

1

5

Small-scale

0.445

High

620388

NUCL
Nucleolin

1

4

Small-scale

0.445

High

634463

LMNB1
Lamin-B1

1

3

Small-scale

0.445

High

665440

EF1B
Elongation factor 1-beta

1

1

Small-scale

0.445

High

761413

HS71L
Heat shock 70 kDa protein 1-like

1

1

Small-scale

0.445

High

801335

HSPA9
Stress-70 protein, mitochondrial

1

5

Small-scale

0.445

High

832903

CETN2
Centrin-2

1

2

Small-scale

0.445

High

910923

IMA1
Importin subunit alpha-1

1

4

Small-scale

0.445

High

967759

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

2

Small-scale

0.445

High

1062481

DHX9
ATP-dependent RNA helicase A

1

2

Small-scale

0.445

High

1089419

ILF2
Interleukin enhancer-binding factor 2

1

1

Small-scale

0.445

High

1096018

TADBP
TAR DNA-binding protein 43

1

5

Small-scale

0.445

High

1157642

DDB1
DNA damage-binding protein 1

1

2

Small-scale

0.445

High

1157644

H2B2E
Histone H2B type 2-E

1

4

Small-scale

0.445

High

1157665

DDX17
Probable ATP-dependent RNA helicase DDX17

1

5

Small-scale

0.445

High

1157668

H2B1A
Histone H2B type 1-A

1

3

Small-scale

0.445

High

1157672

DNJC7
DnaJ homolog subfamily C member 7

1

5

Small-scale

0.445

High

705356

GRN
Progranulin

1

1

High-throughput

0.439

High

1157690

DEC1
Deleted in esophageal cancer 1

1

1

High-throughput

0.439

High

610680

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.437

High

899401

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.437

High

920814

ACLY
ATP-citrate synthase

1

1

High-throughput

0.437

High

1124256

IF4A2
Eukaryotic initiation factor 4A-II

1

9

High-throughput

0.437

High

1157650

SCYL2
SCY1-like protein 2

1

1

High-throughput

0.437

High

180295

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

Small-scale

0.426

High

181893

SMAD9
Mothers against decapentaplegic homolog 9

1

0

Small-scale

0.426

High

183343

ZN185
Zinc finger protein 185

1

0

Small-scale

0.426

High

476701

RSSA
Small ribosomal subunit protein uS2

1

0

Small-scale

0.426

High

612656

RL7
Large ribosomal subunit protein uL30

1

0

Small-scale

0.426

High

785196

RL4
Large ribosomal subunit protein uL4

1

0

Small-scale

0.426

High

833278

PERI
Peripherin

1

0

Small-scale

0.426

High

855095

NOP2
28S rRNA

1

0

Small-scale

0.426

High

860530

RS5
Small ribosomal subunit protein uS7

1

0

Small-scale

0.426

High

947333

NAL11
NACHT, LRR and PYD domains-containing protein 11

1

0

Small-scale

0.426

High

967447

RS7
Small ribosomal subunit protein eS7

1

0

Small-scale

0.426

High

972874

RS18
Small ribosomal subunit protein uS13

1

0

Small-scale

0.426

High

975713

RL7A
Large ribosomal subunit protein eL8

1

0

Small-scale

0.426

High

978546

RL23A
Large ribosomal subunit protein uL23

1

0

Small-scale

0.426

High

979730

H4
Histone H4

1

0

Small-scale

0.426

High

994561

YBOX1
Y-box-binding protein 1

1

0

Small-scale

0.426

High

1016026

RL19
Large ribosomal subunit protein eL19

1

0

Small-scale

0.426

High

1044640

ARI5A
AT-rich interactive domain-containing protein 5A

1

0

Small-scale

0.426

High

1057760

RL18
Large ribosomal subunit protein eL18

1

0

Small-scale

0.426

High

1157652

BCOR
BCL-6 corepressor

1

0

Small-scale

0.426

High

1157659

KCD17
BTB/POZ domain-containing protein KCTD17

1

0

High-throughput

0.426

High

1157664

TITIN
Titin

1

0

Small-scale

0.426

High

1157673

PHB2
Prohibitin-2

1

0

Small-scale

0.426

High

1157679

MBB1A
Myb-binding protein 1A

1

0

Small-scale

0.426

High

1157681

HELZ2
3'-5' exoribonuclease HELZ2

1

0

Small-scale

0.426

High

1157683

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

Small-scale

0.426

High

1157684

PININ
Pinin

1

0

Small-scale

0.426

High

1157688

AATF
Protein AATF

1

0

Small-scale

0.426

High

1157689

BCLF1
Bcl-2-associated transcription factor 1

1

0

Small-scale

0.426

High

75565

B3KSW4
Regulator of G protein signaling 20

1

1

High-throughput

0.407

High

660636

IF4B
Eukaryotic translation initiation factor 4B

1

3

Small-scale

0.407

High

1124963

RCN2
Reticulocalbin-2

1

2

Small-scale

0.407

High

1157651

CC171
Coiled-coil domain-containing protein 171

1

1

Small-scale

0.407

High

1157656

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

Small-scale

0.407

High

1157661

SHRM3
Protein Shroom3

1

1

Small-scale

0.407

High

1157686

YTDC2
3'-5' RNA helicase YTHDC2

1

2

Small-scale

0.407

High

911927

JAK3
Tyrosine-protein kinase JAK3

1

0

High-throughput

0.279

Low

1157657

RAB43
Ras-related protein Rab-43

1

0

High-throughput

0.279

Low

1157676

RETNB
Resistin-like beta

1

0

High-throughput

0.279

Low

1157658

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

0

High-throughput

0.251

Low

892467

GUAA
GMP synthase [glutamine-hydrolyzing]

1

0

High-throughput

0.249

Low

1054220

PUR1
Amidophosphoribosyltransferase

1

0

High-throughput

0.249

Low

367

KVD30
Immunoglobulin kappa variable 2D-30

1

0

Small-scale

0.232

Low

47909

S12A8
Solute carrier family 12 member 8

1

0

Small-scale

0.232

Low

62769

XIRP2
Xin actin-binding repeat-containing protein 2

1

0

Small-scale

0.232

Low

160512

IRS4
Insulin receptor substrate 4

1

0

Small-scale

0.232

Low

350369

ABHGA
Phosphatidylserine lipase ABHD16A

1

0

Small-scale

0.232

Low

866698

CAZA2
F-actin-capping protein subunit alpha-2

1

0

Small-scale

0.232

Low

1048285

KPCT
Protein kinase C theta type

1

0

Small-scale

0.232

Low

1105730

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

0

Small-scale

0.232

Low

1117377

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

0

Small-scale

0.232

Low

1119623

CNCG
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

1

0

Small-scale

0.232

Low

1157648

IFT1B
Protein IFIT1 homolog B

1

0

Small-scale

0.232

Low

1157649

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.232

Low

1157654

RAB44
Ras-related protein Rab-44

1

0

Small-scale

0.232

Low

1157693

CFA92
Uncharacterized protein CFAP92

1

0

Small-scale

0.232

Low

1157698

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025