HitPredict

Interactor 1: NFL (P07196)
Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)
Gene: NEFL

Interactor 2: BICD1 (Q96G01)
Protein bicaudal D homolog 1 (Bic-D 1)
Gene: BICD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005200 - structural constituent of cytoskeleton GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 543 Hs			1 975
+	Hs
		422245 NFL_HUMAN (1-543): 1.42e-151: 446: 100.00		BICD2_HUMAN (6-812): 6.16e-59: 219: 62.93
+	Mm
		440276 NFL_MOUSE (1-543): 1.57e-148: 439: 93.93		BICD1_MOUSE (1-815): 1.04e-59: 221: 96.20
+	Hs
		409173 K2C8_HUMAN (69-431): 4.2e-132: 394: 36.44		BICD2_HUMAN (6-812): 6.16e-59: 219: 62.93
+	Hs
		1081747 AINX_HUMAN (66-401): 1.66e-91: 290: 58.11		BICD1_HUMAN (1-975): 3.32e-75: 268: 100.00
+	Hs
		443721 VIME_HUMAN (34-402): 6.74e-84: 270: 49.59		BICD1_HUMAN (1-975): 3.32e-75: 268: 100.00
+	Mm
		93542 NFL_MOUSE (1-543): 1.57e-148: 439: 93.93		DESP_MOUSE (8-517): 4.54e-10: 66: 16.67
+	Mm
		804953 AINX_MOUSE (65-401): 8.37e-89: 283: 56.47		BICD1_MOUSE (1-815): 1.04e-59: 221: 96.20
+	Hs
		408987 K2C8_HUMAN (69-431): 4.2e-132: 394: 36.44		MYH1_HUMAN (483-974): 2.81e-20: 99.4: 9.80
+	Hs
		443679 VIME_HUMAN (34-402): 6.74e-84: 270: 49.59		BICD2_HUMAN (6-812): 6.16e-59: 219: 62.93
+	Hs
		422425 NFM_HUMAN (82-409): 4.21e-72: 249: 54.71		BICD2_HUMAN (6-812): 6.16e-59: 219: 62.93
+	Hs
		408995 K2C8_HUMAN (69-431): 4.2e-132: 394: 36.44		DESP_HUMAN (4-472): 2.07e-10: 67.2: 18.80
+	Hs
		443305 VIME_HUMAN (34-402): 6.74e-84: 270: 49.59		DESP_HUMAN (4-472): 2.07e-10: 67.2: 18.80
+	Hs
		422355 NFM_HUMAN (82-409): 4.21e-72: 249: 54.71		MYH9_HUMAN (558-974): 2.38e-14: 80.1: 10.30
+	Hs
		422410 NFM_HUMAN (82-409): 4.21e-72: 249: 54.71		MRCKA_HUMAN (1-603): 4.57e-14: 79.1: 17.18
+	Mm
		589621 VIME_MOUSE (69-402): 4.03e-81: 263: 51.50		ROCK2_MOUSE (163-805): 5.55e-09: 62.6: 16.64
+	Hs
		422356 NFM_HUMAN (82-409): 4.21e-72: 249: 54.71		MYH10_HUMAN (551-962): 7.13e-13: 75.1: 8.94
+	Hs
		422342 NFM_HUMAN (82-409): 4.21e-72: 249: 54.71		DESP_HUMAN (4-472): 2.07e-10: 67.2: 18.80
+	Hs
		254455 PERI_HUMAN (9-401): 1.77e-69: 232: 48.12		ROCK2_HUMAN (43-768): 1.27e-13: 77.6: 15.15
+	Hs
		551603 DESM_HUMAN (69-402): 4.31e-72: 239: 53.89		DESP_HUMAN (4-472): 2.07e-10: 67.2: 18.80
+	Hs
		535318 GFAP_HUMAN (66-401): 1.36e-70: 234: 48.21		DESP_HUMAN (4-472): 2.07e-10: 67.2: 18.80